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Statements

Subject Item
n2:RIV%2F00216208%3A11310%2F14%3A10286209%21RIV15-MSM-11310___
rdf:type
skos:Concept n18:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1002/cplu.201402194
dcterms:description
4-Hydroxy-3-methoxyphenyl (MOP) and 2,3-dihydrobenzofuran-5-yl (DHB) groups were tested as potential new oxidizable labels for electrochemical detection of DNA. The corresponding 5-aryl-cytosine and 7-aryl-7-deazaadenine 2-deoxyribonucleoside triphosphates (dNTPs) were prepared by the Suzuki coupling of halogenated dNTPs or by triphosphorylation of modified nucleosides, and were incorporated enzymatically into DNA by polymerase. In parallel, the electrochemical behavior of the labeled nucleosides, nucleotides, and DNA was studied to show that most of them give analytically useful signals of oxidation on the carbon electrode. Particularly, MOP appears to be a useful oxidizable DNA label since it offers independent detection of the modified DNA. 4-Hydroxy-3-methoxyphenyl (MOP) and 2,3-dihydrobenzofuran-5-yl (DHB) groups were tested as potential new oxidizable labels for electrochemical detection of DNA. The corresponding 5-aryl-cytosine and 7-aryl-7-deazaadenine 2-deoxyribonucleoside triphosphates (dNTPs) were prepared by the Suzuki coupling of halogenated dNTPs or by triphosphorylation of modified nucleosides, and were incorporated enzymatically into DNA by polymerase. In parallel, the electrochemical behavior of the labeled nucleosides, nucleotides, and DNA was studied to show that most of them give analytically useful signals of oxidation on the carbon electrode. Particularly, MOP appears to be a useful oxidizable DNA label since it offers independent detection of the modified DNA.
dcterms:title
Methoxyphenol and Dihydrobenzofuran as Oxidizable Labels for Electrochemical Detection of DNA Methoxyphenol and Dihydrobenzofuran as Oxidizable Labels for Electrochemical Detection of DNA
skos:prefLabel
Methoxyphenol and Dihydrobenzofuran as Oxidizable Labels for Electrochemical Detection of DNA Methoxyphenol and Dihydrobenzofuran as Oxidizable Labels for Electrochemical Detection of DNA
skos:notation
RIV/00216208:11310/14:10286209!RIV15-MSM-11310___
n3:aktivita
n4:I n4:P
n3:aktivity
I, P(GBP206/12/G151)
n3:cisloPeriodika
12
n3:dodaniDat
n7:2015
n3:domaciTvurceVysledku
n14:6659160
n3:druhVysledku
n11:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
28695
n3:idVysledku
RIV/00216208:11310/14:10286209
n3:jazykVysledku
n19:eng
n3:klicovaSlova
redox labeling; polymerase chain reactions; nucleotides; electrochemistry; DNA
n3:klicoveSlovo
n6:polymerase%20chain%20reactions n6:electrochemistry n6:DNA n6:redox%20labeling n6:nucleotides
n3:kodStatuVydavatele
DE - Spolková republika Německo
n3:kontrolniKodProRIV
[0F255B6EB6AA]
n3:nazevZdroje
ChemPlusChem
n3:obor
n20:CC
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
6
n3:projekt
n16:GBP206%2F12%2FG151
n3:rokUplatneniVysledku
n7:2014
n3:svazekPeriodika
79
n3:tvurceVysledku
Pohl, Radek Simonova, Anna Balintová, Jana Fojta, Miroslav Hocek, Michal Havran, Luděk
n3:wos
000345633900005
s:issn
2192-6506
s:numberOfPages
10
n12:doi
10.1002/cplu.201402194
n17:organizacniJednotka
11310