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Statements

Subject Item
n2:RIV%2F00216208%3A11310%2F14%3A10285610%21RIV15-MSM-11310___
rdf:type
n16:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.1089/scd.2013.0568
dcterms:description
The aim of this study was to investigate the effects of systemically administered bone-marrow-derived mesenchymal stromal cells (MSCs) on the early acute phase of inflammation in the alkali-burned eye. Mice with damaged eyes were either untreated or treated 24 h after the injury with an intravenous administration of fluorescent-dye-labeled MSCs that were unstimulated or pretreated with interleukin-1 alpha (IL-1 alpha), transforming growth factor-beta (TGF-beta), or interferon-gamma (IFN-gamma). Analysis of cell suspensions prepared from the eyes of treated mice on day 3 after the alkali burn revealed that MSCs specifically migrated to the damaged eye and that the number of labeled MSCs was more than 30-times higher in damaged eyes compared with control eyes. The study of the composition of the leukocyte populations within the damaged eyes showed that all types of tested MSCs slightly decreased the number of infiltrating lymphoid and myeloid cells, but only MSCs pretreated with IFN-gamma significantly decreased the percentage of eye-infiltrating cells with a more profound effect on myeloid cells. Determining cytokine and NO production in the damaged eyes confirmed that the most effective immunomodulation was achieved with MSCs pretreated with IFN-gamma, which significantly decreased the levels of the proinflammatory molecules IL-1 alpha, IL-6, and NO. Taken together, the results show that systemically administered MSCs specifically migrate to the damaged eye and that IFN-gamma-pretreated MSCs are superior in inhibiting the acute phase of inflammation, decreasing leukocyte infiltration, and attenuating the early inflammatory environment. The aim of this study was to investigate the effects of systemically administered bone-marrow-derived mesenchymal stromal cells (MSCs) on the early acute phase of inflammation in the alkali-burned eye. Mice with damaged eyes were either untreated or treated 24 h after the injury with an intravenous administration of fluorescent-dye-labeled MSCs that were unstimulated or pretreated with interleukin-1 alpha (IL-1 alpha), transforming growth factor-beta (TGF-beta), or interferon-gamma (IFN-gamma). Analysis of cell suspensions prepared from the eyes of treated mice on day 3 after the alkali burn revealed that MSCs specifically migrated to the damaged eye and that the number of labeled MSCs was more than 30-times higher in damaged eyes compared with control eyes. The study of the composition of the leukocyte populations within the damaged eyes showed that all types of tested MSCs slightly decreased the number of infiltrating lymphoid and myeloid cells, but only MSCs pretreated with IFN-gamma significantly decreased the percentage of eye-infiltrating cells with a more profound effect on myeloid cells. Determining cytokine and NO production in the damaged eyes confirmed that the most effective immunomodulation was achieved with MSCs pretreated with IFN-gamma, which significantly decreased the levels of the proinflammatory molecules IL-1 alpha, IL-6, and NO. Taken together, the results show that systemically administered MSCs specifically migrate to the damaged eye and that IFN-gamma-pretreated MSCs are superior in inhibiting the acute phase of inflammation, decreasing leukocyte infiltration, and attenuating the early inflammatory environment.
dcterms:title
Modulation of the Early Inflammatory Microenvironment in the Alkali-Burned Eye by Systemically Administered Interferon-gamma-Treated Mesenchymal Stromal Cells Modulation of the Early Inflammatory Microenvironment in the Alkali-Burned Eye by Systemically Administered Interferon-gamma-Treated Mesenchymal Stromal Cells
skos:prefLabel
Modulation of the Early Inflammatory Microenvironment in the Alkali-Burned Eye by Systemically Administered Interferon-gamma-Treated Mesenchymal Stromal Cells Modulation of the Early Inflammatory Microenvironment in the Alkali-Burned Eye by Systemically Administered Interferon-gamma-Treated Mesenchymal Stromal Cells
skos:notation
RIV/00216208:11310/14:10285610!RIV15-MSM-11310___
n3:aktivita
n7:S n7:I
n3:aktivity
I, S
n3:cisloPeriodika
20
n3:dodaniDat
n13:2015
n3:domaciTvurceVysledku
n6:2767198 n6:5695678 n6:4822110 n6:7357354 n6:9565612
n3:druhVysledku
n4:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n19:predkladatel
n3:idSjednocenehoVysledku
30224
n3:idVysledku
RIV/00216208:11310/14:10285610
n3:jazykVysledku
n10:eng
n3:klicovaSlova
engraftment; transplantation; surface; reconstruction; differentiation; in-vitro; nitric-oxide; t-cell; corneal epithelium; stem-cells
n3:klicoveSlovo
n8:t-cell n8:stem-cells n8:differentiation n8:transplantation n8:engraftment n8:surface n8:nitric-oxide n8:in-vitro n8:corneal%20epithelium n8:reconstruction
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[3A73CE44E160]
n3:nazevZdroje
Stem Cells and Development
n3:obor
n9:EC
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
6
n3:rokUplatneniVysledku
n13:2014
n3:svazekPeriodika
23
n3:tvurceVysledku
Zajicova, Alena Hájková, Michaela Javorková, Eliška Trošan, Peter Krulová, Magdaléna Holáň, Vladimír
n3:wos
000342614300008
s:issn
1547-3287
s:numberOfPages
11
n17:doi
10.1089/scd.2013.0568
n5:organizacniJednotka
11310