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Statements

Subject Item
n2:RIV%2F00216208%3A11310%2F14%3A10285222%21RIV15-MSM-11310___
rdf:type
n3:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.1128/AAC.02406-13
dcterms:description
We studied the development of antimony-resistant Leishmania infantum in natural vectors Lutzomyia longipalpis and Phlebotomus perniciosus to ascertain the risk of parasite transmission by sand flies. All three resistant strains produced fully mature late-stage infections in sand flies; moreover, the resistant phenotype was maintained after the passage through the vector. These results highlight the risk of circulation of resistant Leishmania strains and question the use of human drugs for treatment of dogs as Leishmania reservoirs. We studied the development of antimony-resistant Leishmania infantum in natural vectors Lutzomyia longipalpis and Phlebotomus perniciosus to ascertain the risk of parasite transmission by sand flies. All three resistant strains produced fully mature late-stage infections in sand flies; moreover, the resistant phenotype was maintained after the passage through the vector. These results highlight the risk of circulation of resistant Leishmania strains and question the use of human drugs for treatment of dogs as Leishmania reservoirs.
dcterms:title
Transmission Potential of Antimony-Resistant Leishmania Field Isolates Transmission Potential of Antimony-Resistant Leishmania Field Isolates
skos:prefLabel
Transmission Potential of Antimony-Resistant Leishmania Field Isolates Transmission Potential of Antimony-Resistant Leishmania Field Isolates
skos:notation
RIV/00216208:11310/14:10285222!RIV15-MSM-11310___
n4:aktivita
n14:P n14:I
n4:aktivity
I, P(GA13-07500S)
n4:cisloPeriodika
10
n4:dodaniDat
n6:2015
n4:domaciTvurceVysledku
n9:3628434 n9:6447910
n4:druhVysledku
n15:J
n4:duvernostUdaju
n17:S
n4:entitaPredkladatele
n12:predkladatel
n4:idSjednocenehoVysledku
51071
n4:idVysledku
RIV/00216208:11310/14:10285222
n4:jazykVysledku
n11:eng
n4:klicovaSlova
sandflies; glucantime; sensitivity; dogs; strains; infection; infantum; life-cycle; visceral leishmaniasis
n4:klicoveSlovo
n7:visceral%20leishmaniasis n7:sandflies n7:sensitivity n7:glucantime n7:dogs n7:infection n7:strains n7:life-cycle n7:infantum
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[C1FCC5647F42]
n4:nazevZdroje
Antimicrobial Agents and Chemotherapy
n4:obor
n19:EE
n4:pocetDomacichTvurcuVysledku
2
n4:pocetTvurcuVysledku
9
n4:projekt
n13:GA13-07500S
n4:rokUplatneniVysledku
n6:2014
n4:svazekPeriodika
58
n4:tvurceVysledku
Sereno, Denis Šeblová, Veronika Gazanion, Elodie Oury, Bruno Eddaikra, Naouel Maia, Carla Ait-Oudhia, Khatima Volf, Petr Pratlong, Francine
n4:wos
000344157500078
s:issn
0066-4804
s:numberOfPages
4
n18:doi
10.1128/AAC.02406-13
n16:organizacniJednotka
11310