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Statements

Subject Item
n2:RIV%2F00216208%3A11310%2F14%3A10209524%21RIV15-MSM-11310___
rdf:type
skos:Concept n12:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1016/j.micres.2013.07.005
dcterms:description
Photodynamic therapy is usually used against malignant and non-malignant tumors. Nowadays, due to resistance of bacterial strains, we are looking for a new antimicrobial strategy to destroy bacteria with minimal invasive consequences. The worldwide increase in antibiotic resistance among different classes of gram-positive and gram-negative bacteria has led to the search for alternative anti-microbial therapies such as antimicrobial PDT (aPDT). Development antimicrobial technology combines a nontoxic compound, called photosensitizer, visible light of the appropriate wavelength, and the generation of reactive oxygen species. In this work, the photosensitizers TMPyP and ZnTPPS4 are investigated for photodynamic and antimicrobial photodynamic therapy. We tested these two porphyrins on two cell lines and two bacterial strains to compare effectiveness. In addition, we applied photosensitizers bound in the complex created with hp-beta-cyclodextrin. The light-emitting diodes were used at the doses 0, 1, 5, 10 J/cm(2) for cells and 0, 150 J/cm(2) for bacteria. Tested concentrations for cells and microbes were from 0.5 to 50 mu M and from 0.78 to 100 mu M, respectively. From this work it can be concluded that TMPyP is a promising compound both in aPDT and in PDT, particularly in contrast to ZnTPPS4, which was efficient only in PDT. Furthermore, the eradication of gram-positive bacteria is possible only with higher concentrations of ZnTPPS4. Photodynamic therapy is usually used against malignant and non-malignant tumors. Nowadays, due to resistance of bacterial strains, we are looking for a new antimicrobial strategy to destroy bacteria with minimal invasive consequences. The worldwide increase in antibiotic resistance among different classes of gram-positive and gram-negative bacteria has led to the search for alternative anti-microbial therapies such as antimicrobial PDT (aPDT). Development antimicrobial technology combines a nontoxic compound, called photosensitizer, visible light of the appropriate wavelength, and the generation of reactive oxygen species. In this work, the photosensitizers TMPyP and ZnTPPS4 are investigated for photodynamic and antimicrobial photodynamic therapy. We tested these two porphyrins on two cell lines and two bacterial strains to compare effectiveness. In addition, we applied photosensitizers bound in the complex created with hp-beta-cyclodextrin. The light-emitting diodes were used at the doses 0, 1, 5, 10 J/cm(2) for cells and 0, 150 J/cm(2) for bacteria. Tested concentrations for cells and microbes were from 0.5 to 50 mu M and from 0.78 to 100 mu M, respectively. From this work it can be concluded that TMPyP is a promising compound both in aPDT and in PDT, particularly in contrast to ZnTPPS4, which was efficient only in PDT. Furthermore, the eradication of gram-positive bacteria is possible only with higher concentrations of ZnTPPS4.
dcterms:title
The application of antimicrobial photodynamic therapy on S. aureus and E. coli using porphyrin photosensitizers bound to cyclodextrin The application of antimicrobial photodynamic therapy on S. aureus and E. coli using porphyrin photosensitizers bound to cyclodextrin
skos:prefLabel
The application of antimicrobial photodynamic therapy on S. aureus and E. coli using porphyrin photosensitizers bound to cyclodextrin The application of antimicrobial photodynamic therapy on S. aureus and E. coli using porphyrin photosensitizers bound to cyclodextrin
skos:notation
RIV/00216208:11310/14:10209524!RIV15-MSM-11310___
n3:aktivita
n19:S n19:P n19:I
n3:aktivity
I, P(ED0030/01/01), P(GD303/09/H048), S
n3:cisloPeriodika
2-3
n3:dodaniDat
n10:2015
n3:domaciTvurceVysledku
n8:5799457
n3:druhVysledku
n20:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
3713
n3:idVysledku
RIV/00216208:11310/14:10209524
n3:jazykVysledku
n5:eng
n3:klicovaSlova
porphyrins; gram-negative bacteria; gram-positive bacteria; antimicrobial photodynamic therapy; photodynamic therapy
n3:klicoveSlovo
n6:photodynamic%20therapy n6:gram-negative%20bacteria n6:gram-positive%20bacteria n6:antimicrobial%20photodynamic%20therapy n6:porphyrins
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[AA6A1285C5C5]
n3:nazevZdroje
Microbiological Research
n3:obor
n4:BO
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
11
n3:projekt
n14:ED0030%2F01%2F01 n14:GD303%2F09%2FH048
n3:rokUplatneniVysledku
n10:2014
n3:svazekPeriodika
169
n3:tvurceVysledku
Kolářová, Hana Kolář, Milan Tománková, Kateřina Bogdanová, Kateřina Mosinger, Jiří Binder, Svatopluk Malohlava, Jakub Langová, Kateřina Hanáková, Adéla Pížová, Klára Bajgar, Robert
n3:wos
000330335600007
s:issn
0944-5013
s:numberOfPages
8
n9:doi
10.1016/j.micres.2013.07.005
n7:organizacniJednotka
11310