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Statements

Subject Item
n2:RIV%2F00216208%3A11310%2F14%3A10196792%21RIV15-MSM-11310___
rdf:type
skos:Concept n15:Vysledek
rdfs:seeAlso
http://link.springer.com/article/10.1007/s12104-013-9531-1
dcterms:description
We report the backbone 1H, 13C and 15N assignments of NMR resonances for the 47 kDa Cytosolic dNT-1 nucleotidase dimer. Cytosolic dNT-1 nucleotidase plays a key role in the homeostasis of pyrimidine deoxyribonucleotides in mammalian cells. The enzyme is responsible for the dephosphorylation of physiological substrates as well as nucleoside analogues that are used in antiviral and anticancer therapies, therefore selective inhibition of the dNT-1 nucleotidase activity may lead to an increase in efficacy of this type of therapeutic compounds. Here, we report the backbone H-1, C-13 and N-15 assignments for the 47 kDa dNT-1 dimer, which will be used for structural characterisation of dNT-1 complexes with small molecule inhibitors obtained through modification of pyrimidine nucleotide scaffolds or optimisation of successful binders obtained from the screening of fragment libraries. We report the backbone 1H, 13C and 15N assignments of NMR resonances for the 47 kDa Cytosolic dNT-1 nucleotidase dimer. Cytosolic dNT-1 nucleotidase plays a key role in the homeostasis of pyrimidine deoxyribonucleotides in mammalian cells. The enzyme is responsible for the dephosphorylation of physiological substrates as well as nucleoside analogues that are used in antiviral and anticancer therapies, therefore selective inhibition of the dNT-1 nucleotidase activity may lead to an increase in efficacy of this type of therapeutic compounds. Here, we report the backbone H-1, C-13 and N-15 assignments for the 47 kDa dNT-1 dimer, which will be used for structural characterisation of dNT-1 complexes with small molecule inhibitors obtained through modification of pyrimidine nucleotide scaffolds or optimisation of successful binders obtained from the screening of fragment libraries.
dcterms:title
Backbone resonance assignments of human cytosolic dNT-1 nucleotidase Backbone resonance assignments of human cytosolic dNT-1 nucleotidase
skos:prefLabel
Backbone resonance assignments of human cytosolic dNT-1 nucleotidase Backbone resonance assignments of human cytosolic dNT-1 nucleotidase
skos:notation
RIV/00216208:11310/14:10196792!RIV15-MSM-11310___
n4:aktivita
n6:P n6:I
n4:aktivity
I, P(GA203/09/0820), P(LK11205)
n4:cisloPeriodika
2
n4:dodaniDat
n10:2015
n4:domaciTvurceVysledku
n18:3324923
n4:druhVysledku
n20:J
n4:duvernostUdaju
n17:S
n4:entitaPredkladatele
n13:predkladatel
n4:idSjednocenehoVysledku
4748
n4:idVysledku
RIV/00216208:11310/14:10196792
n4:jazykVysledku
n9:eng
n4:klicovaSlova
pyrimidine nucleotides; dimer; perdeuterated protein; 5 '-nucleotidase; haloacid dehalogenase superfamily; NMR; backbone assignments
n4:klicoveSlovo
n8:dimer n8:pyrimidine%20nucleotides n8:backbone%20assignments n8:5%20%27-nucleotidase n8:perdeuterated%20protein n8:NMR n8:haloacid%20dehalogenase%20superfamily
n4:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n4:kontrolniKodProRIV
[A2D96FD79640]
n4:nazevZdroje
Biomolecular NMR Assignments
n4:obor
n16:CE
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
7
n4:projekt
n11:LK11205 n11:GA203%2F09%2F0820
n4:rokUplatneniVysledku
n10:2014
n4:svazekPeriodika
8
n4:tvurceVysledku
Skleničková, Radka Veverka, Václav Fábry, Milan Hnízda, Aleš Tošner, Zdeněk Brynda, Jiří Pachl, Petr
n4:wos
000342080900042
s:issn
1874-2718
s:numberOfPages
4
n14:doi
10.1007/s12104-013-9531-1
n7:organizacniJednotka
11310