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Statements

Subject Item
n2:RIV%2F00216208%3A11310%2F13%3A10192132%21RIV14-MSM-11310___
rdf:type
skos:Concept n10:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1186/1471-2148-13-107
dcterms:description
Background: Retrotransposons have been suggested to provide a substrate for non-allelic homologous recombination (NAHR) and thereby promote gene family expansion. Their precise role, however, is controversial. Here we ask whether retrotransposons contributed to the recent expansions of the Androgen-binding protein (Abp) gene families that occurred independently in the mouse and rat genomes. Results: Using dot plot analysis, we found that the most recent duplication in the Abp region of the mouse genome is flanked by L1Md_T elements. Analysis of the sequence of these elements revealed breakpoints that are the relicts of the recombination that caused the duplication, confirming that the duplication arose as a result of NAHR using L1 elements as substrates. L1 and ERVII retrotransposons are considerably denser in the Abp regions than in one Mb flanking regions, while other repeat types are depleted in the Abp regions compared to flanking regions. L1 retrotransposons preferentially accumulated in the Abp gene regions after lineage separation and roughly followed the pattern of Abp gene expansion. By contrast, the proportion of shared vs. lineage-specific ERVII repeats in the Abp region resembles the rest of the genome. Conclusions: We confirmed the role of L1 repeats in Abp gene duplication with the identification of recombinant L1Md_T elements at the edges of the most recent mouse Abp gene duplication. High densities of L1 and ERVII repeats were found in the Abp gene region with abrupt transitions at the region boundaries, suggesting that their higher densities are tightly associated with Abp gene duplication. We observed that the major accumulation of L1 elements occurred after the split of the mouse and rat lineages and that there is a striking overlap between the timing of L1 accumulation and expansion of the Abp gene family in the mouse genome. Background: Retrotransposons have been suggested to provide a substrate for non-allelic homologous recombination (NAHR) and thereby promote gene family expansion. Their precise role, however, is controversial. Here we ask whether retrotransposons contributed to the recent expansions of the Androgen-binding protein (Abp) gene families that occurred independently in the mouse and rat genomes. Results: Using dot plot analysis, we found that the most recent duplication in the Abp region of the mouse genome is flanked by L1Md_T elements. Analysis of the sequence of these elements revealed breakpoints that are the relicts of the recombination that caused the duplication, confirming that the duplication arose as a result of NAHR using L1 elements as substrates. L1 and ERVII retrotransposons are considerably denser in the Abp regions than in one Mb flanking regions, while other repeat types are depleted in the Abp regions compared to flanking regions. L1 retrotransposons preferentially accumulated in the Abp gene regions after lineage separation and roughly followed the pattern of Abp gene expansion. By contrast, the proportion of shared vs. lineage-specific ERVII repeats in the Abp region resembles the rest of the genome. Conclusions: We confirmed the role of L1 repeats in Abp gene duplication with the identification of recombinant L1Md_T elements at the edges of the most recent mouse Abp gene duplication. High densities of L1 and ERVII repeats were found in the Abp gene region with abrupt transitions at the region boundaries, suggesting that their higher densities are tightly associated with Abp gene duplication. We observed that the major accumulation of L1 elements occurred after the split of the mouse and rat lineages and that there is a striking overlap between the timing of L1 accumulation and expansion of the Abp gene family in the mouse genome.
dcterms:title
The role of retrotransposons in gene family expansions: insights from the mouse Abp gene family The role of retrotransposons in gene family expansions: insights from the mouse Abp gene family
skos:prefLabel
The role of retrotransposons in gene family expansions: insights from the mouse Abp gene family The role of retrotransposons in gene family expansions: insights from the mouse Abp gene family
skos:notation
RIV/00216208:11310/13:10192132!RIV14-MSM-11310___
n10:predkladatel
n11:orjk%3A11310
n4:aktivita
n17:I n17:S
n4:aktivity
I, S
n4:cisloPeriodika
107
n4:dodaniDat
n12:2014
n4:domaciTvurceVysledku
n14:4117700
n4:druhVysledku
n16:J
n4:duvernostUdaju
n20:S
n4:entitaPredkladatele
n7:predkladatel
n4:idSjednocenehoVysledku
103366
n4:idVysledku
RIV/00216208:11310/13:10192132
n4:jazykVysledku
n13:eng
n4:klicovaSlova
NAHR; ERVII; LINE1; Androgen-binding protein; Gene duplication; House mouse
n4:klicoveSlovo
n9:Androgen-binding%20protein n9:NAHR n9:House%20mouse n9:ERVII n9:LINE1 n9:Gene%20duplication
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[39716EED4C0A]
n4:nazevZdroje
BMC Evolutionary Biology
n4:obor
n18:EG
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
3
n4:rokUplatneniVysledku
n12:2013
n4:svazekPeriodika
13
n4:tvurceVysledku
Laukaitis, Christina M. Janoušek, Václav Karn, Robert C.
n4:wos
000319825700001
s:issn
1471-2148
s:numberOfPages
12
n8:doi
10.1186/1471-2148-13-107
n19:organizacniJednotka
11310