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Statements

Subject Item
n2:RIV%2F00216208%3A11310%2F13%3A10191499%21RIV14-MSM-11310___
rdf:type
n9:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.1002/jez.b.22502
dcterms:description
In mice, a toothless diastema separates the single incisor from the three molars in each dental quadrant. In the prospective diastema of the embryo, small rudimentary buds are found that are presumed to be rudiments of suppressed teeth. A supernumerary tooth occurs in the diastema of adult mice carrying mutations in either Spry2 or Spry4. In the case of Spry2 mutants, the origin of the supernumerary tooth involves the revitalization of a rudimentary tooth bud (called R2), whereas its origin in the Spry4 mutants is not known. In addition to R2, another rudimentary primordium (called MS) arises more anteriorly in the prospective diastema. We investigated the participation of both rudiments (MS and R2) in supernumerary tooth development in Spry2 and Spry4 mutants by comparing morphogenesis, proliferation, apoptosis, size and Shh expression in the dental epithelium of MS and R2 rudiments. Increased proliferation and decreased apoptosis were found in MS and R2 at embryonic day (ED) 12.5 and 13.5 in Spry2-/- embryos. Apoptosis was also decreased in both rudiments in Spry4-/- embryos, but the proliferation was lower (similar to WT mice), and supernumerary tooth development was accelerated, exhibiting a cap stage by ED13.5. Compared to Spry2-/- mice, a high number of Spry4-/- supernumerary tooth primordia degenerated after ED13.5, resulting in a low percentage of supernumerary teeth in adults. We propose that Sprouty genes were implicated during evolution in reduction of the cheek teeth in Muridae, and their deletion can reveal ancestral stages of murine dental evolution. J. Exp. Zool. (Mol. Dev. Evol.) 320B:307-320, 2013. (c) 2013 Wiley Periodicals, Inc. In mice, a toothless diastema separates the single incisor from the three molars in each dental quadrant. In the prospective diastema of the embryo, small rudimentary buds are found that are presumed to be rudiments of suppressed teeth. A supernumerary tooth occurs in the diastema of adult mice carrying mutations in either Spry2 or Spry4. In the case of Spry2 mutants, the origin of the supernumerary tooth involves the revitalization of a rudimentary tooth bud (called R2), whereas its origin in the Spry4 mutants is not known. In addition to R2, another rudimentary primordium (called MS) arises more anteriorly in the prospective diastema. We investigated the participation of both rudiments (MS and R2) in supernumerary tooth development in Spry2 and Spry4 mutants by comparing morphogenesis, proliferation, apoptosis, size and Shh expression in the dental epithelium of MS and R2 rudiments. Increased proliferation and decreased apoptosis were found in MS and R2 at embryonic day (ED) 12.5 and 13.5 in Spry2-/- embryos. Apoptosis was also decreased in both rudiments in Spry4-/- embryos, but the proliferation was lower (similar to WT mice), and supernumerary tooth development was accelerated, exhibiting a cap stage by ED13.5. Compared to Spry2-/- mice, a high number of Spry4-/- supernumerary tooth primordia degenerated after ED13.5, resulting in a low percentage of supernumerary teeth in adults. We propose that Sprouty genes were implicated during evolution in reduction of the cheek teeth in Muridae, and their deletion can reveal ancestral stages of murine dental evolution. J. Exp. Zool. (Mol. Dev. Evol.) 320B:307-320, 2013. (c) 2013 Wiley Periodicals, Inc.
dcterms:title
The Dynamics of Supernumerary Tooth Development Are Differentially Regulated by Sprouty Genes The Dynamics of Supernumerary Tooth Development Are Differentially Regulated by Sprouty Genes
skos:prefLabel
The Dynamics of Supernumerary Tooth Development Are Differentially Regulated by Sprouty Genes The Dynamics of Supernumerary Tooth Development Are Differentially Regulated by Sprouty Genes
skos:notation
RIV/00216208:11310/13:10191499!RIV14-MSM-11310___
n9:predkladatel
n20:orjk%3A11310
n3:aktivita
n15:P n15:I
n3:aktivity
I, P(GAP305/12/1766)
n3:cisloPeriodika
5
n3:dodaniDat
n11:2014
n3:domaciTvurceVysledku
n13:2937360
n3:druhVysledku
n17:J
n3:duvernostUdaju
n10:S
n3:entitaPredkladatele
n21:predkladatel
n3:idSjednocenehoVysledku
70976
n3:idVysledku
RIV/00216208:11310/13:10191499
n3:jazykVysledku
n16:eng
n3:klicovaSlova
morphogenesis; lower jaw; tabby/eda mice; spatial-distribution; enamel knot; mouse odontogenesis; 3-dimensional reconstruction; sonic-hedgehog; 1st lower molar; embryonic signaling center
n3:klicoveSlovo
n4:spatial-distribution n4:morphogenesis n4:1st%20lower%20molar n4:mouse%20odontogenesis n4:lower%20jaw n4:tabby%2Feda%20mice n4:3-dimensional%20reconstruction n4:sonic-hedgehog n4:embryonic%20signaling%20center n4:enamel%20knot
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[88A578E4C3CA]
n3:nazevZdroje
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution
n3:obor
n5:EA
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
7
n3:projekt
n8:GAP305%2F12%2F1766
n3:rokUplatneniVysledku
n11:2013
n3:svazekPeriodika
320B
n3:tvurceVysledku
Lesot, Herve Vojtechova, Simona Peterka, Miroslav Klein, Ophir D. Lagronová, Svatava Spoutil, František Peterkova, Renata
n3:wos
000320170600006
s:issn
1552-5007
s:numberOfPages
14
n12:doi
10.1002/jez.b.22502
n19:organizacniJednotka
11310