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Statements

Subject Item
n2:RIV%2F00216208%3A11310%2F13%3A10189226%21RIV14-MSM-11310___
rdf:type
n15:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.1007/s12015-013-9449-0
dcterms:description
Ocular surface defects represent one of the most common causes of impaired vision or even blindness. For treatment, keratoplasty represents the first choice. However, if corneal defects are more extensive and associated with a limbal stem cell (LSC) deficiency, corneal transplantation is not a sufficient therapeutic procedure and only viable approach to treatment is the transplantation of LSCs. When the LSC deficiency is a bilateral disorder, autologous LSCs are not available. The use of allogeneic LSCs requires strong immunosuppression, which leads to side-effects, and the treatment is not always effective. The alternative and perspective approach to the treatment of severe ocular surface injuries and LSC deficiency is offered by the transplantation of autologous mesenchymal stem cells (MSCs). These cells can be obtained from the bone marrow or adipose tissue of the particular patient, grow well in vitro and can be transferred, using an appropriate scaffold, onto the damaged ocular surface. Here they exert beneficial effects by possible direct differentiation into corneal epithelial cells, by immunomodulatory effects and by the production of numerous trophic and growth factors. Recent experiments utilizing the therapeutic properties of MSCs in animal models with a mechanically or chemically injured ocular surface have yielded promising results and demonstrated significant corneal regeneration, improved corneal transparency and a rapid healing process associated with the restoration of vision. The use of autologous MSCs thus represents a promising therapeutic approach and offers hope for patients with severe ocular surface injuries and LSC deficiency. Ocular surface defects represent one of the most common causes of impaired vision or even blindness. For treatment, keratoplasty represents the first choice. However, if corneal defects are more extensive and associated with a limbal stem cell (LSC) deficiency, corneal transplantation is not a sufficient therapeutic procedure and only viable approach to treatment is the transplantation of LSCs. When the LSC deficiency is a bilateral disorder, autologous LSCs are not available. The use of allogeneic LSCs requires strong immunosuppression, which leads to side-effects, and the treatment is not always effective. The alternative and perspective approach to the treatment of severe ocular surface injuries and LSC deficiency is offered by the transplantation of autologous mesenchymal stem cells (MSCs). These cells can be obtained from the bone marrow or adipose tissue of the particular patient, grow well in vitro and can be transferred, using an appropriate scaffold, onto the damaged ocular surface. Here they exert beneficial effects by possible direct differentiation into corneal epithelial cells, by immunomodulatory effects and by the production of numerous trophic and growth factors. Recent experiments utilizing the therapeutic properties of MSCs in animal models with a mechanically or chemically injured ocular surface have yielded promising results and demonstrated significant corneal regeneration, improved corneal transparency and a rapid healing process associated with the restoration of vision. The use of autologous MSCs thus represents a promising therapeutic approach and offers hope for patients with severe ocular surface injuries and LSC deficiency.
dcterms:title
Mesenchymal Stem Cells, Nanofiber Scaffolds and Ocular Surface Reconstruction Mesenchymal Stem Cells, Nanofiber Scaffolds and Ocular Surface Reconstruction
skos:prefLabel
Mesenchymal Stem Cells, Nanofiber Scaffolds and Ocular Surface Reconstruction Mesenchymal Stem Cells, Nanofiber Scaffolds and Ocular Surface Reconstruction
skos:notation
RIV/00216208:11310/13:10189226!RIV14-MSM-11310___
n15:predkladatel
n22:orjk%3A11310
n3:aktivita
n18:I n18:S n18:P n18:Z
n3:aktivity
I, P(GAP301/11/1568), P(GAP304/11/0653), S, Z(MSM0021620858)
n3:cisloPeriodika
5
n3:dodaniDat
n10:2014
n3:domaciTvurceVysledku
n8:5695678 n8:2767198
n3:druhVysledku
n17:J
n3:duvernostUdaju
n21:S
n3:entitaPredkladatele
n14:predkladatel
n3:idSjednocenehoVysledku
87410
n3:idVysledku
RIV/00216208:11310/13:10189226
n3:jazykVysledku
n13:eng
n3:klicovaSlova
Cornea reconstruction; Immunosuppression; Nanofiber scaffolds; Ocular surface injuries; Limbal stem cells; Mesenchymal stem cells
n3:klicoveSlovo
n11:Immunosuppression n11:Limbal%20stem%20cells n11:Cornea%20reconstruction n11:Nanofiber%20scaffolds n11:Mesenchymal%20stem%20cells n11:Ocular%20surface%20injuries
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[88037BB3189C]
n3:nazevZdroje
Stem Cell Reviews and Reports
n3:obor
n9:EC
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
2
n3:projekt
n12:GAP304%2F11%2F0653 n12:GAP301%2F11%2F1568
n3:rokUplatneniVysledku
n10:2013
n3:svazekPeriodika
9
n3:tvurceVysledku
Javorková, Eliška Holáň, Vladimír
n3:wos
000325031100008
n3:zamer
n4:MSM0021620858
s:issn
1550-8943
s:numberOfPages
10
n19:doi
10.1007/s12015-013-9449-0
n5:organizacniJednotka
11310