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Statements

Subject Item
n2:RIV%2F00216208%3A11310%2F13%3A10159258%21RIV14-MSM-11310___
rdf:type
n5:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.1016/j.bmc.2013.06.011
dcterms:description
Two series of new 4-aminopyrimido[4,5-b]indole ribonucleosides bearing phenyl or hetaryl group at position 5 or 6 have been prepared by Suzuki or Stille cross-coupling reactions employing X-Phos ligand with (het)arylboronic acids or stannanes. A series of 4-substituted nucleosides has been also prepared by Pd-catalyzed cross-couplings or nucleophilic substitution. Some of these compounds displayed moderate antiviral activities against HCV and dengue viruses. Two series of new 4-aminopyrimido[4,5-b]indole ribonucleosides bearing phenyl or hetaryl group at position 5 or 6 have been prepared by Suzuki or Stille cross-coupling reactions employing X-Phos ligand with (het)arylboronic acids or stannanes. A series of 4-substituted nucleosides has been also prepared by Pd-catalyzed cross-couplings or nucleophilic substitution. Some of these compounds displayed moderate antiviral activities against HCV and dengue viruses.
dcterms:title
Synthesis and biological activity of benzo-fused 7-deazaadenosine analogues. 5-and 6-substituted 4-amino- or 4-allcylpyrimido [4,5-b]indole ribonucleosides Synthesis and biological activity of benzo-fused 7-deazaadenosine analogues. 5-and 6-substituted 4-amino- or 4-allcylpyrimido [4,5-b]indole ribonucleosides
skos:prefLabel
Synthesis and biological activity of benzo-fused 7-deazaadenosine analogues. 5-and 6-substituted 4-amino- or 4-allcylpyrimido [4,5-b]indole ribonucleosides Synthesis and biological activity of benzo-fused 7-deazaadenosine analogues. 5-and 6-substituted 4-amino- or 4-allcylpyrimido [4,5-b]indole ribonucleosides
skos:notation
RIV/00216208:11310/13:10159258!RIV14-MSM-11310___
n5:predkladatel
n12:orjk%3A11310
n3:aktivita
n13:I
n3:aktivity
I
n3:cisloPeriodika
17
n3:dodaniDat
n16:2014
n3:domaciTvurceVysledku
n20:6659160
n3:druhVysledku
n9:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
109461
n3:idVysledku
RIV/00216208:11310/13:10159258
n3:jazykVysledku
n10:eng
n3:klicovaSlova
anti-dengue virus activity; Suzuki and Stille cross-coupling; 5-6]indoles; pyrimido[4; nucleosides
n3:klicoveSlovo
n4:anti-dengue%20virus%20activity n4:nucleosides n4:5-6%5Dindoles n4:Suzuki%20and%20Stille%20cross-coupling n4:pyrimido%5B4
n3:kodStatuVydavatele
DE - Spolková republika Německo
n3:kontrolniKodProRIV
[1DA5AA8F14F0]
n3:nazevZdroje
Bioorganic and Medicinal Chemistry
n3:obor
n7:CC
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
7
n3:rokUplatneniVysledku
n16:2013
n3:svazekPeriodika
21
n3:tvurceVysledku
Lee, Yu-Jen Hocek, Michal Weber, Jan Pohl, Radek Tichý, Michal Tloušťová, Eva Bahador, Gina
n3:wos
000323294600054
s:issn
0968-0896
s:numberOfPages
11
n11:doi
10.1016/j.bmc.2013.06.011
n19:organizacniJednotka
11310