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Statements

Subject Item
n2:RIV%2F00216208%3A11310%2F13%3A10139607%21RIV14-MSM-11310___
rdf:type
skos:Concept n11:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1039/c3tb20473a
dcterms:description
We have developed an engineered hydrogel formed, in the absence of any toxic solvents or reagents, by spontaneous self-assembly of three key components: a poly-beta-cyclodextrin polymer (1), a hydrophobically modified dextran (2) and a nitric oxide (NO) photodonor bearing an adamantyl appendage (3). The formation of this supramolecular assembly is based on a %22lock-and-key%22 mechanism in which the alkyl side chains of 2 and the adamantane moiety of 3 form inclusion complexes with the beta-CD cavities of 1. The multivalent character of the interactions between all components and the insolubility of the NO photodonor in an aqueous medium ensure the stability of the hydrogel and the total lack of leaching of the photoactive component from the gel network under physiological conditions, even in the absence of protective coating agents. The photochemical properties of the NO photodonor are well preserved in the supramolecular matrix as demonstrated by the remote-controlled release of NO through visible light excitation and its transfer to a protein such as myoglobin. The utility of this NO photoreleasing platform is demonstrated in effective and strictly light-dependent bactericidal activity against the Gram-negative Escherichia coli bacterial colony suspension. We have developed an engineered hydrogel formed, in the absence of any toxic solvents or reagents, by spontaneous self-assembly of three key components: a poly-beta-cyclodextrin polymer (1), a hydrophobically modified dextran (2) and a nitric oxide (NO) photodonor bearing an adamantyl appendage (3). The formation of this supramolecular assembly is based on a %22lock-and-key%22 mechanism in which the alkyl side chains of 2 and the adamantane moiety of 3 form inclusion complexes with the beta-CD cavities of 1. The multivalent character of the interactions between all components and the insolubility of the NO photodonor in an aqueous medium ensure the stability of the hydrogel and the total lack of leaching of the photoactive component from the gel network under physiological conditions, even in the absence of protective coating agents. The photochemical properties of the NO photodonor are well preserved in the supramolecular matrix as demonstrated by the remote-controlled release of NO through visible light excitation and its transfer to a protein such as myoglobin. The utility of this NO photoreleasing platform is demonstrated in effective and strictly light-dependent bactericidal activity against the Gram-negative Escherichia coli bacterial colony suspension.
dcterms:title
A NO photoreleasing supramolecular hydrogel with bactericidal action A NO photoreleasing supramolecular hydrogel with bactericidal action
skos:prefLabel
A NO photoreleasing supramolecular hydrogel with bactericidal action A NO photoreleasing supramolecular hydrogel with bactericidal action
skos:notation
RIV/00216208:11310/13:10139607!RIV14-MSM-11310___
n11:predkladatel
n12:orjk%3A11310
n3:aktivita
n15:I
n3:aktivity
I
n3:cisloPeriodika
28
n3:dodaniDat
n4:2014
n3:domaciTvurceVysledku
n9:5799457
n3:druhVysledku
n13:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n19:predkladatel
n3:idSjednocenehoVysledku
58864
n3:idVysledku
RIV/00216208:11310/13:10139607
n3:jazykVysledku
n14:eng
n3:klicovaSlova
light; driven; nitrosyl; pathways; myoglobin; flutamide; nanoparticles; beta-cyclodextrin; nitric-oxide release
n3:klicoveSlovo
n10:light n10:nanoparticles n10:driven n10:flutamide n10:nitrosyl n10:nitric-oxide%20release n10:pathways n10:myoglobin n10:beta-cyclodextrin
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[E6FF21F0065E]
n3:nazevZdroje
Journal of Materials Chemistry B
n3:obor
n20:CA
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
4
n3:rokUplatneniVysledku
n4:2013
n3:svazekPeriodika
1
n3:tvurceVysledku
Gref, Ruxandra Kandoth, Noufal Sortino, Salvatore Mosinger, Jiří
n3:wos
000320951700004
s:issn
2050-750X
s:numberOfPages
6
n8:doi
10.1039/c3tb20473a
n16:organizacniJednotka
11310