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Statements

Subject Item
n2:RIV%2F00216208%3A11310%2F13%3A10139591%21RIV14-MSM-11310___
rdf:type
n3:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.1021/ml400042w
dcterms:description
In an effort toward the visualization of beta-amyloid plaques by in vivo imaging techniques, we have conjugated an optimized derivative of the Pittsburgh compound B (PiB), a well-established marker of Afi plaques, to DO3A-monoamide that is capable of forming stable, noncharged complexes with different trivalent metal ions including Gd3+ for MRI and In-111(3+). for SPECT applications. Proton relaxivity measurements evidenced binding of Gd(DO3A-PiB) to the amyloid peptide A beta(1-40) and to human serum albumin, resulting in a two- and four-fold relaidvity increase, respectively. Ex vivo immunohistochemical studies showed that the DO3A-PiB complexes selectively target A beta plaques on Alzheimer's disease human brain tissue. Ex vivo biodistribution data obtained for the In-111-analogue pointed to a moderate blood-brain barrier (BBB) penetration in adult male Swiss mice (without amyloid deposits) with 0.36% ID/g in the cortex at 2 min postinjection. In an effort toward the visualization of beta-amyloid plaques by in vivo imaging techniques, we have conjugated an optimized derivative of the Pittsburgh compound B (PiB), a well-established marker of Afi plaques, to DO3A-monoamide that is capable of forming stable, noncharged complexes with different trivalent metal ions including Gd3+ for MRI and In-111(3+). for SPECT applications. Proton relaxivity measurements evidenced binding of Gd(DO3A-PiB) to the amyloid peptide A beta(1-40) and to human serum albumin, resulting in a two- and four-fold relaidvity increase, respectively. Ex vivo immunohistochemical studies showed that the DO3A-PiB complexes selectively target A beta plaques on Alzheimer's disease human brain tissue. Ex vivo biodistribution data obtained for the In-111-analogue pointed to a moderate blood-brain barrier (BBB) penetration in adult male Swiss mice (without amyloid deposits) with 0.36% ID/g in the cortex at 2 min postinjection.
dcterms:title
PiB-Conjugated, Metal-Based Imaging Probes: Multimodal Approaches for the Visualization of beta-Amyloid Plaques PiB-Conjugated, Metal-Based Imaging Probes: Multimodal Approaches for the Visualization of beta-Amyloid Plaques
skos:prefLabel
PiB-Conjugated, Metal-Based Imaging Probes: Multimodal Approaches for the Visualization of beta-Amyloid Plaques PiB-Conjugated, Metal-Based Imaging Probes: Multimodal Approaches for the Visualization of beta-Amyloid Plaques
skos:notation
RIV/00216208:11310/13:10139591!RIV14-MSM-11310___
n3:predkladatel
n8:orjk%3A11310
n4:aktivita
n12:S n12:I
n4:aktivity
I, S
n4:cisloPeriodika
5
n4:dodaniDat
n6:2014
n4:domaciTvurceVysledku
n20:1015133
n4:druhVysledku
n9:J
n4:duvernostUdaju
n16:S
n4:entitaPredkladatele
n15:predkladatel
n4:idSjednocenehoVysledku
96213
n4:idVysledku
RIV/00216208:11310/13:10139591
n4:jazykVysledku
n10:eng
n4:klicovaSlova
Pittsburgh compound B; Alzheimer's disease; amyloid plaques; In-111(3+); Gd3+; imaging agents
n4:klicoveSlovo
n5:Pittsburgh%20compound%20B n5:imaging%20agents n5:In-111%283%2B%29 n5:Gd3%2B n5:amyloid%20plaques n5:Alzheimer%27s%20disease
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[9DB7A3B4A0EB]
n4:nazevZdroje
ACS Medicinal Chemistry Letters
n4:obor
n14:FR
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
13
n4:rokUplatneniVysledku
n6:2013
n4:svazekPeriodika
4
n4:tvurceVysledku
Lazar, Adina N. Arlicot, Nicolas Buron, Frederic Guilloteau, Denis Morfin, Jean-Francois Suzenet, Franck Geraldes, Carlos F. G. C. Salerno, Milena Toth, Eva Duyckaerts, Charles Kubicek, Vojtěch Martins, Andre F. Kubíčková, Anna
n4:wos
000318892800005
s:issn
1948-5875
s:numberOfPages
5
n13:doi
10.1021/ml400042w
n11:organizacniJednotka
11310