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Statements

Subject Item
n2:RIV%2F00216208%3A11310%2F12%3A10129944%21RIV13-GA0-11310___
rdf:type
skos:Concept n11:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1111/j.1365-294X.2012.05583.x
dcterms:description
Studies of a hybrid zone between two house mouse subspecies (Mus musculus musculus and M. m. domesticus) along with studies using laboratory crosses reveal a large role for the X chromosome and multiple autosomal regions in reproductive isolation as a consequence of disrupted epistasis in hybrids. One limitation of previous work has been that most of the identified genomic regions have been large. The goal here is to detect and characterize precise genomic regions underlying reproductive isolation. We surveyed 1401 markers evenly spaced across the genome in 679 mice collected from two different transects. Comparisons between transects provide a means for identifying common patterns that likely reflect intrinsic incompatibilities. We used a genomic cline approach to identify patterns that correspond to epistasis. From both transects,we identified contiguous regions on the X chromosome in which markers were inferred to be involved in epistatic interactions.Wethen searched for autosomal regions showing the same patterns and found they constitute about 5% of autosomal markers. We discovered substantial overlap between these candidate regions underlying reproductive isolation and QTL for hybrid sterility identified in laboratory crosses. Analysis of gene content in these regions suggests a key role for several mechanisms, including the regulation of transcription, sexual conflict and sexual selection operating at both the postmating prezygotic and postzygotic stages of reproductive isolation. Taken together, these results indicate that speciation in two recently diverged (c. 0.5 Ma) house mouse subspecies is complex, involving many genes dispersed throughout the genome and associated with distinct functions. Studies of a hybrid zone between two house mouse subspecies (Mus musculus musculus and M. m. domesticus) along with studies using laboratory crosses reveal a large role for the X chromosome and multiple autosomal regions in reproductive isolation as a consequence of disrupted epistasis in hybrids. One limitation of previous work has been that most of the identified genomic regions have been large. The goal here is to detect and characterize precise genomic regions underlying reproductive isolation. We surveyed 1401 markers evenly spaced across the genome in 679 mice collected from two different transects. Comparisons between transects provide a means for identifying common patterns that likely reflect intrinsic incompatibilities. We used a genomic cline approach to identify patterns that correspond to epistasis. From both transects,we identified contiguous regions on the X chromosome in which markers were inferred to be involved in epistatic interactions.Wethen searched for autosomal regions showing the same patterns and found they constitute about 5% of autosomal markers. We discovered substantial overlap between these candidate regions underlying reproductive isolation and QTL for hybrid sterility identified in laboratory crosses. Analysis of gene content in these regions suggests a key role for several mechanisms, including the regulation of transcription, sexual conflict and sexual selection operating at both the postmating prezygotic and postzygotic stages of reproductive isolation. Taken together, these results indicate that speciation in two recently diverged (c. 0.5 Ma) house mouse subspecies is complex, involving many genes dispersed throughout the genome and associated with distinct functions.
dcterms:title
Genome-wide architecture of reproductive isolation in a naturally occurring hybrid zone between Mus musculus musculus and M. m. domesticus Genome-wide architecture of reproductive isolation in a naturally occurring hybrid zone between Mus musculus musculus and M. m. domesticus
skos:prefLabel
Genome-wide architecture of reproductive isolation in a naturally occurring hybrid zone between Mus musculus musculus and M. m. domesticus Genome-wide architecture of reproductive isolation in a naturally occurring hybrid zone between Mus musculus musculus and M. m. domesticus
skos:notation
RIV/00216208:11310/12:10129944!RIV13-GA0-11310___
n11:predkladatel
n19:orjk%3A11310
n3:aktivita
n13:P n13:I
n3:aktivity
I, P(GA206/08/0640)
n3:cisloPeriodika
12
n3:dodaniDat
n4:2013
n3:domaciTvurceVysledku
n9:7605463 n9:4117700
n3:druhVysledku
n15:J
n3:duvernostUdaju
n7:S
n3:entitaPredkladatele
n14:predkladatel
n3:idSjednocenehoVysledku
137975
n3:idVysledku
RIV/00216208:11310/12:10129944
n3:jazykVysledku
n17:eng
n3:klicovaSlova
speciation; mammals; hybridization; genomics / proteomics
n3:klicoveSlovo
n5:hybridization n5:mammals n5:genomics%20%2F%20proteomics n5:speciation
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[E9AF100F4EF1]
n3:nazevZdroje
Molecular Ecology
n3:obor
n21:EG
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
10
n3:projekt
n18:GA206%2F08%2F0640
n3:rokUplatneniVysledku
n4:2012
n3:svazekPeriodika
21
n3:tvurceVysledku
Wang, Liuyang Tucker, Priscilla K. Vyskocilova, Martina M. Nachman, Michael W. Macholan, Milos Munclinger, Pavel Janoušek, Václav Luzynski, Ken Pialek, Jaroslav Dufkova, Petra
n3:wos
000304903100019
s:issn
0962-1083
s:numberOfPages
16
n16:doi
10.1111/j.1365-294X.2012.05583.x
n20:organizacniJednotka
11310