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Statements

Subject Item
n2:RIV%2F00216208%3A11310%2F12%3A10126423%21RIV13-GA0-11310___
rdf:type
n3:Vysledek skos:Concept
dcterms:description
Supramolecular interactions of various organic xenobiotic compounds with DNA are among the most important aspects of biological studies in clinical analysis, drug discovery, and pharmaceutical development processes. In recent years, there has been a growing interest in the electrochemical investigation of interactions between studied analytes and DNA. Observing the pre- and post-electrochemical signals of DNA or monitoring its interaction with xenobiotics provides good evidence for the interaction mechanism to be elucidated. Such interaction can also be used for sensitive determination of these compounds. This short review should provide evidence that the electrochemical approach brings new insight into human health protection or rational drug design and leads to further understanding of the interaction mechanism between organic xenobiotic compounds and DNA. Supramolecular interactions of various organic xenobiotic compounds with DNA are among the most important aspects of biological studies in clinical analysis, drug discovery, and pharmaceutical development processes. In recent years, there has been a growing interest in the electrochemical investigation of interactions between studied analytes and DNA. Observing the pre- and post-electrochemical signals of DNA or monitoring its interaction with xenobiotics provides good evidence for the interaction mechanism to be elucidated. Such interaction can also be used for sensitive determination of these compounds. This short review should provide evidence that the electrochemical approach brings new insight into human health protection or rational drug design and leads to further understanding of the interaction mechanism between organic xenobiotic compounds and DNA.
dcterms:title
Electrochemical DNA Biosensors - Useful Diagnostic Tools for the Detection of Damage to DNA Caused by Organic Xenobiotics (A Review) Electrochemical DNA Biosensors - Useful Diagnostic Tools for the Detection of Damage to DNA Caused by Organic Xenobiotics (A Review)
skos:prefLabel
Electrochemical DNA Biosensors - Useful Diagnostic Tools for the Detection of Damage to DNA Caused by Organic Xenobiotics (A Review) Electrochemical DNA Biosensors - Useful Diagnostic Tools for the Detection of Damage to DNA Caused by Organic Xenobiotics (A Review)
skos:notation
RIV/00216208:11310/12:10126423!RIV13-GA0-11310___
n3:predkladatel
n16:orjk%3A11310
n5:aktivita
n6:Z n6:S n6:P
n5:aktivity
P(GBP206/12/G151), P(ME10004), S, Z(MSM0021620857)
n5:dodaniDat
n13:2013
n5:domaciTvurceVysledku
n12:9357653 n12:9470921 n12:2463288 n12:8805865 n12:4017811 n12:3609634
n5:druhVysledku
n15:O
n5:duvernostUdaju
n17:S
n5:entitaPredkladatele
n7:predkladatel
n5:idSjednocenehoVysledku
133867
n5:idVysledku
RIV/00216208:11310/12:10126423
n5:jazykVysledku
n14:eng
n5:klicovaSlova
Review.; DNA damage detection; DNA biosensors; Supramolecular chemistry
n5:klicoveSlovo
n10:Review. n10:DNA%20biosensors n10:DNA%20damage%20detection n10:Supramolecular%20chemistry
n5:kontrolniKodProRIV
[0D4070D42138]
n5:obor
n18:CG
n5:pocetDomacichTvurcuVysledku
6
n5:pocetTvurcuVysledku
7
n5:projekt
n9:ME10004 n9:GBP206%2F12%2FG151
n5:rokUplatneniVysledku
n13:2012
n5:tvurceVysledku
Stávková, Klára Wang, Joseph Horáková, Eva Blašková, Marta Vyskočil, Vlastimil Hájková, Andrea Krejčová, Zuzana
n5:zamer
n19:MSM0021620857
n4:organizacniJednotka
11310