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Statements

Subject Item
n2:RIV%2F00216208%3A11310%2F12%3A10124831%21RIV13-MSM-11310___
rdf:type
skos:Concept n10:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1016/j.nucmedbio.2012.04.007
dcterms:description
Purpose: Bone metastases are a serious aggravation for patients suffering from cancer. Therefore, early recognition of bone metastases is of great interest for further treatment of patients. Bisphosphonates are widely used for scintigraphy of bone lesions with Tc-99m. Using the Ge-68/Ga-68 generator together with a macroyclic bisphosphonate a comparable PET-tracer comes into focus. Procedures: The bisphosphonate DOTA-conjugated ligand BPAMD was labelled with Ga-68. [Ga-68]BPAMD was evaluated in vitro concerning binding to hydroxyapatite and stability. The tracer's in vivo accumulation was determined on healthy rats and bone metastases bearing animals by mu-PET. Results: BPAMD was labelled efficiently with 68Ga after 10 min at 100 degrees C. [Ga-68]BPAMD allowed high in vitro stability within 3 h and high binding to hydroxyapatite. Consequently, mu-PET experiments revealed high accumulation of [Ga-68]BPAMD in regions of pronounced remodelling activity like bone metastases. Conclusions: Ga-68 BPAMD reveals great potential for diagnosis of bone metastases via PET/CT. The straight forward Ga-68-labelling could be transferred to a kit-preparation of a cyclotron-independent PET tracer instantaneously available in many clinical sites using the Ge-68/Ga-68 generator. Purpose: Bone metastases are a serious aggravation for patients suffering from cancer. Therefore, early recognition of bone metastases is of great interest for further treatment of patients. Bisphosphonates are widely used for scintigraphy of bone lesions with Tc-99m. Using the Ge-68/Ga-68 generator together with a macroyclic bisphosphonate a comparable PET-tracer comes into focus. Procedures: The bisphosphonate DOTA-conjugated ligand BPAMD was labelled with Ga-68. [Ga-68]BPAMD was evaluated in vitro concerning binding to hydroxyapatite and stability. The tracer's in vivo accumulation was determined on healthy rats and bone metastases bearing animals by mu-PET. Results: BPAMD was labelled efficiently with 68Ga after 10 min at 100 degrees C. [Ga-68]BPAMD allowed high in vitro stability within 3 h and high binding to hydroxyapatite. Consequently, mu-PET experiments revealed high accumulation of [Ga-68]BPAMD in regions of pronounced remodelling activity like bone metastases. Conclusions: Ga-68 BPAMD reveals great potential for diagnosis of bone metastases via PET/CT. The straight forward Ga-68-labelling could be transferred to a kit-preparation of a cyclotron-independent PET tracer instantaneously available in many clinical sites using the Ge-68/Ga-68 generator.
dcterms:title
Ga-68-BPAMD: PET-imaging of bone metastases with a generator based positron emitter Ga-68-BPAMD: PET-imaging of bone metastases with a generator based positron emitter
skos:prefLabel
Ga-68-BPAMD: PET-imaging of bone metastases with a generator based positron emitter Ga-68-BPAMD: PET-imaging of bone metastases with a generator based positron emitter
skos:notation
RIV/00216208:11310/12:10124831!RIV13-MSM-11310___
n10:predkladatel
n11:orjk%3A11310
n3:aktivita
n12:P n12:I
n3:aktivity
I, P(OC 179)
n3:cisloPeriodika
7
n3:dodaniDat
n16:2013
n3:domaciTvurceVysledku
n15:3978877 n15:9695656
n3:druhVysledku
n4:J
n3:duvernostUdaju
n21:S
n3:entitaPredkladatele
n20:predkladatel
n3:idSjednocenehoVysledku
137748
n3:idVysledku
RIV/00216208:11310/12:10124831
n3:jazykVysledku
n14:eng
n3:klicovaSlova
bone metastases; bisphosphonate; macrocylic ligand; Ga-68
n3:klicoveSlovo
n5:macrocylic%20ligand n5:Ga-68 n5:bone%20metastases n5:bisphosphonate
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[D1F3F41E7E06]
n3:nazevZdroje
Nuclear Medicine and Biology
n3:obor
n6:CA
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
7
n3:projekt
n7:OC%20179
n3:rokUplatneniVysledku
n16:2012
n3:svazekPeriodika
39
n3:tvurceVysledku
Fellner, Marco Roesch, Frank Bausbacher, Nicole Thews, Oliver Hermann, Petr Kubíček, Vojtěch Biesalski, Barbara
n3:wos
000309033800016
s:issn
0969-8051
s:numberOfPages
7
n18:doi
10.1016/j.nucmedbio.2012.04.007
n8:organizacniJednotka
11310