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Statements

Subject Item
n2:RIV%2F00216208%3A11310%2F12%3A10120765%21RIV13-GA0-11310___
rdf:type
n17:Vysledek skos:Concept
rdfs:seeAlso
http://www.cell.com/molecular-cell/abstract/S1097-2765(12)00266-3
dcterms:description
Nutrient sensing and metabolic reprogramming are crucial for metazoan cell aging and tumor growth. Here, we identify metabolic and regulatory parallels between a layered, multicellular yeast colony and a tumor-affected organism. During development, a yeast colony stratifies into U and L cells occupying the upper and lower colony regions, respectively. U cells activate a unique metabolism controlled by the glutamine-induced TOR pathway, amino acid sensing systems (SPS and Gcn4p) and signaling from mitochondria with lowered respiration. These systems jointly modulate U cell physiology, which adapts to nutrient limitations and utilize the nutrients released from L cells. Stress-resistant U cells share metabolic pathways and other similar characteristics with tumor cells, including the ability to proliferate. L cells behave similarly to stressed and starving cells, which activate degradative mechanisms to provide nutrients to U cells. Our data suggest a nutrient flow between both cell types, resembling the Cori cycle and glutamine-NH4 + shuttle between tumor and healthy metazoan cells. Nutrient sensing and metabolic reprogramming are crucial for metazoan cell aging and tumor growth. Here, we identify metabolic and regulatory parallels between a layered, multicellular yeast colony and a tumor-affected organism. During development, a yeast colony stratifies into U and L cells occupying the upper and lower colony regions, respectively. U cells activate a unique metabolism controlled by the glutamine-induced TOR pathway, amino acid sensing systems (SPS and Gcn4p) and signaling from mitochondria with lowered respiration. These systems jointly modulate U cell physiology, which adapts to nutrient limitations and utilize the nutrients released from L cells. Stress-resistant U cells share metabolic pathways and other similar characteristics with tumor cells, including the ability to proliferate. L cells behave similarly to stressed and starving cells, which activate degradative mechanisms to provide nutrients to U cells. Our data suggest a nutrient flow between both cell types, resembling the Cori cycle and glutamine-NH4 + shuttle between tumor and healthy metazoan cells.
dcterms:title
Cell Differentiation within a Yeast Colony: Metabolic and Regulatory Parallels with a Tumor-Affected Organism Cell Differentiation within a Yeast Colony: Metabolic and Regulatory Parallels with a Tumor-Affected Organism
skos:prefLabel
Cell Differentiation within a Yeast Colony: Metabolic and Regulatory Parallels with a Tumor-Affected Organism Cell Differentiation within a Yeast Colony: Metabolic and Regulatory Parallels with a Tumor-Affected Organism
skos:notation
RIV/00216208:11310/12:10120765!RIV13-GA0-11310___
n17:predkladatel
n21:orjk%3A11310
n4:aktivita
n14:Z n14:I n14:P
n4:aktivity
I, P(GA204/08/0718), P(LC531), Z(MSM0021620858)
n4:cisloPeriodika
4
n4:dodaniDat
n7:2013
n4:domaciTvurceVysledku
n9:3930823 n9:2477777 n9:1892746 n9:2234025
n4:druhVysledku
n20:J
n4:duvernostUdaju
n16:S
n4:entitaPredkladatele
n10:predkladatel
n4:idSjednocenehoVysledku
126223
n4:idVysledku
RIV/00216208:11310/12:10120765
n4:jazykVysledku
n22:eng
n4:klicovaSlova
amino acid sensing systems; TOR pathway; U and L cells; yeast colony; metabolic reprogramming; nutrient sensing
n4:klicoveSlovo
n6:nutrient%20sensing n6:U%20and%20L%20cells n6:amino%20acid%20sensing%20systems n6:yeast%20colony n6:metabolic%20reprogramming n6:TOR%20pathway
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[97F096800C7E]
n4:nazevZdroje
Molecular Cell
n4:obor
n11:EB
n4:pocetDomacichTvurcuVysledku
4
n4:pocetTvurcuVysledku
5
n4:projekt
n12:GA204%2F08%2F0718 n12:LC531
n4:rokUplatneniVysledku
n7:2012
n4:svazekPeriodika
46
n4:tvurceVysledku
Čáp, Michal Palková, Zdena Váchová, Libuše Harant, Karel Štěpánek, Luděk
n4:wos
000304518900008
n4:zamer
n15:MSM0021620858
s:issn
1097-2765
s:numberOfPages
13
n13:doi
10.1016/j.molcel.2012.04.001
n19:organizacniJednotka
11310