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Statements

Subject Item
n2:RIV%2F00216208%3A11310%2F12%3A10106097%21RIV13-MSM-11310___
rdf:type
n15:Vysledek skos:Concept
dcterms:description
The TOR protein kinase functions in two distinct complexes, TOR complex 1 (TORC1) and 2 (TORC2). TORC1 is required for growth in response to growth factors, nutrients and the cellular energy state; TORC2 regulates AKT signaling, which can modulate cytoskeletal polarization. In its ecological niche, Dictyostelium engulf bacteria and yeast for nutrient capture. Despite the essential role of TORC1 in control of cellular growth, we show that nutrient particle capture (phagocytosis) in Dictyostelium is independent of TORC1-mediated nutrient sensing and growth regulation. However, loss of Dictyostelium TORC2 components Rictor/Pia, SIN1/RIP3 and Lst8 promotes nutrient particle uptake; inactivation of TORC2 leads to increased efficiency and speed of phagocytosis. In contrast to phagocytosis, we show that macropinocytosis, an AKT-dependent process for cellular uptake of fluid phase nutrients, is not regulated by either of the TOR complexes. The integrated and balanced regulation of TORC1 and TORC2 might be crucial in Dictyostelium to coordinate growth and energy needs with other essential TOR-regulated processes. The TOR protein kinase functions in two distinct complexes, TOR complex 1 (TORC1) and 2 (TORC2). TORC1 is required for growth in response to growth factors, nutrients and the cellular energy state; TORC2 regulates AKT signaling, which can modulate cytoskeletal polarization. In its ecological niche, Dictyostelium engulf bacteria and yeast for nutrient capture. Despite the essential role of TORC1 in control of cellular growth, we show that nutrient particle capture (phagocytosis) in Dictyostelium is independent of TORC1-mediated nutrient sensing and growth regulation. However, loss of Dictyostelium TORC2 components Rictor/Pia, SIN1/RIP3 and Lst8 promotes nutrient particle uptake; inactivation of TORC2 leads to increased efficiency and speed of phagocytosis. In contrast to phagocytosis, we show that macropinocytosis, an AKT-dependent process for cellular uptake of fluid phase nutrients, is not regulated by either of the TOR complexes. The integrated and balanced regulation of TORC1 and TORC2 might be crucial in Dictyostelium to coordinate growth and energy needs with other essential TOR-regulated processes.
dcterms:title
TOR complex 2 (TORC2) in Dictyostelium suppresses phagocytic nutrient capture independently of TORC1-mediated nutrient sensing. TOR complex 2 (TORC2) in Dictyostelium suppresses phagocytic nutrient capture independently of TORC1-mediated nutrient sensing.
skos:prefLabel
TOR complex 2 (TORC2) in Dictyostelium suppresses phagocytic nutrient capture independently of TORC1-mediated nutrient sensing. TOR complex 2 (TORC2) in Dictyostelium suppresses phagocytic nutrient capture independently of TORC1-mediated nutrient sensing.
skos:notation
RIV/00216208:11310/12:10106097!RIV13-MSM-11310___
n15:predkladatel
n19:orjk%3A11310
n3:aktivita
n6:I
n3:aktivity
I
n3:cisloPeriodika
1
n3:dodaniDat
n9:2013
n3:domaciTvurceVysledku
n17:3950441
n3:druhVysledku
n7:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
174633
n3:idVysledku
RIV/00216208:11310/12:10106097
n3:jazykVysledku
n12:eng
n3:klicovaSlova
Dictyostelium; 4E-BP; FKBP12; Actin; Raptor; Rapamycin
n3:klicoveSlovo
n4:Dictyostelium n4:Actin n4:FKBP12 n4:4E-BP n4:Rapamycin n4:Raptor
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[A4EABF6DEAC7]
n3:nazevZdroje
Journal of Cell Science
n3:obor
n5:EB
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
6
n3:rokUplatneniVysledku
n9:2012
n3:svazekPeriodika
125
n3:tvurceVysledku
Majithia, A. Rösel, Daniel Bhandari, R. Huang, X. Khurana, T. Kimmel, AR
n3:wos
000300329100005
s:issn
0021-9533
s:numberOfPages
12
n14:doi
10.1242/jcs.077040
n10:organizacniJednotka
11310