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Statements

Subject Item
n2:RIV%2F00216208%3A11310%2F12%3A10104201%21RIV13-MSM-11310___
rdf:type
n13:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.1016/j.imbio.2011.07.032
dcterms:description
Development and differentiation of Th cells is highly plastic and strictly regulated by cytokines. We show negative regulation of TGF-beta-dependent differentiation programs by IL-12. Development of TGF-b-induced regulatory T cells (iTregs) or TGF-b/IL-6-activated Th17 cells from purified mouse CD4+CD25- T cells stimulated with anti-CD3 was abrogated by IL-12, establishing different developmental program. IL-12 inhibited expression of lineage-specific transcription factors Foxp3 and RORgt in developing Tregs and Th17 cells. IL-12 altered development of iTregs and Th17 cells even added after 48 h. Cells activated by TGF-b and IL-12 had increased expression of T-bet, produced Th1 cytokines IFN-g and IL-2 and expressed IL-18 receptor and C-C chemokine receptor type 5. Cells activated by both TGF-b and IL-12 stimulated macrophages to produce nitric oxide. IL-12 is shown as superior cytokine able to skew ongoing TGF-b-dependent iTreg or Th17 developmental program to Th1-like direction. Development and differentiation of Th cells is highly plastic and strictly regulated by cytokines. We show negative regulation of TGF-beta-dependent differentiation programs by IL-12. Development of TGF-b-induced regulatory T cells (iTregs) or TGF-b/IL-6-activated Th17 cells from purified mouse CD4+CD25- T cells stimulated with anti-CD3 was abrogated by IL-12, establishing different developmental program. IL-12 inhibited expression of lineage-specific transcription factors Foxp3 and RORgt in developing Tregs and Th17 cells. IL-12 altered development of iTregs and Th17 cells even added after 48 h. Cells activated by TGF-b and IL-12 had increased expression of T-bet, produced Th1 cytokines IFN-g and IL-2 and expressed IL-18 receptor and C-C chemokine receptor type 5. Cells activated by both TGF-b and IL-12 stimulated macrophages to produce nitric oxide. IL-12 is shown as superior cytokine able to skew ongoing TGF-b-dependent iTreg or Th17 developmental program to Th1-like direction.
dcterms:title
IL-12 inhibits the TGF-beta-dependent T cell developmental programs and skews the TGF-beta-induced differentiation into a Th1-like direction IL-12 inhibits the TGF-beta-dependent T cell developmental programs and skews the TGF-beta-induced differentiation into a Th1-like direction
skos:prefLabel
IL-12 inhibits the TGF-beta-dependent T cell developmental programs and skews the TGF-beta-induced differentiation into a Th1-like direction IL-12 inhibits the TGF-beta-dependent T cell developmental programs and skews the TGF-beta-induced differentiation into a Th1-like direction
skos:notation
RIV/00216208:11310/12:10104201!RIV13-MSM-11310___
n13:predkladatel
n14:orjk%3A11310
n3:aktivita
n10:Z n10:S n10:P
n3:aktivity
P(1M0506), P(GAP301/11/1568), P(GAP304/11/0653), P(GD310/08/H077), P(KAN200520804), S, Z(AV0Z50520514), Z(MSM0021620858)
n3:cisloPeriodika
1
n3:dodaniDat
n12:2013
n3:domaciTvurceVysledku
n8:2523329 n8:5695678 n8:5865689
n3:druhVysledku
n16:J
n3:duvernostUdaju
n6:S
n3:entitaPredkladatele
n11:predkladatel
n3:idSjednocenehoVysledku
140479
n3:idVysledku
RIV/00216208:11310/12:10104201
n3:jazykVysledku
n18:eng
n3:klicovaSlova
T cell subsets; T cell differentiation; cytokines
n3:klicoveSlovo
n5:T%20cell%20differentiation n5:T%20cell%20subsets n5:cytokines
n3:kodStatuVydavatele
DE - Spolková republika Německo
n3:kontrolniKodProRIV
[958ABBD7B8ED]
n3:nazevZdroje
Immunobiology
n3:obor
n20:EC
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
3
n3:projekt
n4:GAP304%2F11%2F0653 n4:GAP301%2F11%2F1568 n4:KAN200520804 n4:1M0506 n4:GD310%2F08%2FH077
n3:rokUplatneniVysledku
n12:2012
n3:svazekPeriodika
217
n3:tvurceVysledku
Holáň, Vladimír Pokorná, Kateřina Procházková, Jana
n3:wos
000299445400011
n3:zamer
n15:AV0Z50520514 n15:MSM0021620858
s:issn
0171-2985
s:numberOfPages
9
n21:doi
10.1016/j.imbio.2011.07.032
n22:organizacniJednotka
11310