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Statements

Subject Item
n2:RIV%2F00216208%3A11310%2F11%3A10108168%21RIV12-MSM-11310___
rdf:type
skos:Concept n16:Vysledek
rdfs:seeAlso
http://www.plosntds.org/article/info%3Adoi%2F10.1371%2Fjournal.pntd.0001296
dcterms:description
Background: Visceral leishmaniasis is the world' second largest vector-borne parasitic killer and a neglected tropical disease, prevalent in poor communities. Long-lasting insecticidal nets (LNs) are a low cost proven vector intervention method for malaria control; however, their effectiveness against visceral leishmaniasis (VL) is unknown. This study quantified the effect of LNs on exposure to the sand fly vector of VL in India and Nepal during a two year community intervention trial. Methods: As part of a paired-cluster randomized controlled clinical trial in VL-endemic regions of India and Nepal we tested the effect of LNs on sand fly biting by measuring the antibody response of subjects to the saliva of Leishmania donovani vector Phlebotomus argentipes and the sympatric (non-vector) Phlebotomus papatasi. Fifteen to 20 individuals above 15 years of age from 26 VL endemic clusters were asked to provide a blood sample at baseline, 12 and 24 months post-intervention. Results: A total of 305 individuals were included in the study, 68 participants provided two blood samples and 237 gave three samples. A random effect linear regression model showed that cluster-wide distribution of LNs reduced exposure to P. argentipes by 12% at 12 months (effect 0.88; 95% CI 0.83-0.94) and 9% at 24 months (effect 0.91; 95% CI 0.80-1.02) in the intervention group compared to control adjusting for baseline values and pair. Similar results were obtained for P. papatasi. Conclusions: This trial provides evidence that LNs have a limited effect on sand fly exposure in VL endemic communities in India and Nepal and supports the use of sand fly saliva antibodies as a marker to evaluate vector control interventions. Background: Visceral leishmaniasis is the world' second largest vector-borne parasitic killer and a neglected tropical disease, prevalent in poor communities. Long-lasting insecticidal nets (LNs) are a low cost proven vector intervention method for malaria control; however, their effectiveness against visceral leishmaniasis (VL) is unknown. This study quantified the effect of LNs on exposure to the sand fly vector of VL in India and Nepal during a two year community intervention trial. Methods: As part of a paired-cluster randomized controlled clinical trial in VL-endemic regions of India and Nepal we tested the effect of LNs on sand fly biting by measuring the antibody response of subjects to the saliva of Leishmania donovani vector Phlebotomus argentipes and the sympatric (non-vector) Phlebotomus papatasi. Fifteen to 20 individuals above 15 years of age from 26 VL endemic clusters were asked to provide a blood sample at baseline, 12 and 24 months post-intervention. Results: A total of 305 individuals were included in the study, 68 participants provided two blood samples and 237 gave three samples. A random effect linear regression model showed that cluster-wide distribution of LNs reduced exposure to P. argentipes by 12% at 12 months (effect 0.88; 95% CI 0.83-0.94) and 9% at 24 months (effect 0.91; 95% CI 0.80-1.02) in the intervention group compared to control adjusting for baseline values and pair. Similar results were obtained for P. papatasi. Conclusions: This trial provides evidence that LNs have a limited effect on sand fly exposure in VL endemic communities in India and Nepal and supports the use of sand fly saliva antibodies as a marker to evaluate vector control interventions.
dcterms:title
Serological Markers of Sand Fly Exposure to Evaluate Insecticidal Nets against Visceral Leishmaniasis in India and Nepal: A Cluster-Randomized Trial Serological Markers of Sand Fly Exposure to Evaluate Insecticidal Nets against Visceral Leishmaniasis in India and Nepal: A Cluster-Randomized Trial
skos:prefLabel
Serological Markers of Sand Fly Exposure to Evaluate Insecticidal Nets against Visceral Leishmaniasis in India and Nepal: A Cluster-Randomized Trial Serological Markers of Sand Fly Exposure to Evaluate Insecticidal Nets against Visceral Leishmaniasis in India and Nepal: A Cluster-Randomized Trial
skos:notation
RIV/00216208:11310/11:10108168!RIV12-MSM-11310___
n16:predkladatel
n17:orjk%3A11310
n3:aktivita
n18:Z
n3:aktivity
Z(MSM0021620828)
n3:cisloPeriodika
9
n3:dodaniDat
n19:2012
n3:domaciTvurceVysledku
n10:6447910 n10:7188056
n3:druhVysledku
n13:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n12:predkladatel
n3:idSjednocenehoVysledku
228956
n3:idVysledku
RIV/00216208:11310/11:10108168
n3:jazykVysledku
n21:eng
n3:klicovaSlova
PROTEINS; SUBCONTINENT; SANDFLIES; BIHAR; TREATED NETS; DONOVANI INFECTION; VECTOR CONTROL; ANTIBODY-RESPONSE; PHLEBOTOMUS-ARGENTIPES; LUTZOMYIA-LONGIPALPIS SALIVA
n3:klicoveSlovo
n9:BIHAR n9:LUTZOMYIA-LONGIPALPIS%20SALIVA n9:PROTEINS n9:TREATED%20NETS n9:SANDFLIES n9:ANTIBODY-RESPONSE n9:DONOVANI%20INFECTION n9:PHLEBOTOMUS-ARGENTIPES n9:VECTOR%20CONTROL n9:SUBCONTINENT
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[972DEE15DB00]
n3:nazevZdroje
PLoS Neglected Tropical Diseases
n3:obor
n11:EG
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
15
n3:rokUplatneniVysledku
n19:2011
n3:svazekPeriodika
5
n3:tvurceVysledku
Singh, Shri Prakash Sundar, Shyam Andersen, Elisabeth Wreford Sudarshan, Medhavi Chakravarty, Jaya Volf, Petr Picado, Albert Roy, Lalita Ostyn, Bart Volfová, Věra Rijal, Suman Boelaert, Marleen Uranw, Surendra Rogers, Matthew Edward Gidwani, Kamlesh
n3:wos
000296578900010
n3:zamer
n6:MSM0021620828
s:issn
1935-2727
s:numberOfPages
8
n20:doi
10.1371/journal.pntd.0001296
n8:organizacniJednotka
11310