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Statements

Subject Item
n2:RIV%2F00216208%3A11310%2F11%3A10107363%21RIV12-GA0-11310___
rdf:type
n6:Vysledek skos:Concept
dcterms:description
Ingestion of aristolochic acid (AA) is associated with development of urothelial tumors linked with aristolochic acid nephropathy, and is implicated in the development of Balkan endemic nephropathy-associated urothelial tumors. Aristolochic acid I (AAI), the major toxic component of AA, is more toxic than its demethoxylated derivate AAII. A different enzymatic conversion of both carcinogens might be one of the reasons explaining this feature. Therefore, the present study has been designed to compare efficiency of human NAD(P)H:quinone oxidoreductase (NQO1) and phase II enzymes such as sulfotransferases (SULTs) and N,O-acetyltransferases (NATs) to activate AAI and AAII in vitro. In addition, to investigate the molecular mechanisms of AAI and AAII reduction by human NQO1, molecular modeling was used to compare interactions of AAI and AAII with the active site of this enzyme. Ingestion of aristolochic acid (AA) is associated with development of urothelial tumors linked with aristolochic acid nephropathy, and is implicated in the development of Balkan endemic nephropathy-associated urothelial tumors. Aristolochic acid I (AAI), the major toxic component of AA, is more toxic than its demethoxylated derivate AAII. A different enzymatic conversion of both carcinogens might be one of the reasons explaining this feature. Therefore, the present study has been designed to compare efficiency of human NAD(P)H:quinone oxidoreductase (NQO1) and phase II enzymes such as sulfotransferases (SULTs) and N,O-acetyltransferases (NATs) to activate AAI and AAII in vitro. In addition, to investigate the molecular mechanisms of AAI and AAII reduction by human NQO1, molecular modeling was used to compare interactions of AAI and AAII with the active site of this enzyme.
dcterms:title
Comparison of activation of aristolochic acid I and II with NADPH:quinone oxidoreductase, sulphotransferases and N-acetyltranferases Comparison of activation of aristolochic acid I and II with NADPH:quinone oxidoreductase, sulphotransferases and N-acetyltranferases
skos:prefLabel
Comparison of activation of aristolochic acid I and II with NADPH:quinone oxidoreductase, sulphotransferases and N-acetyltranferases Comparison of activation of aristolochic acid I and II with NADPH:quinone oxidoreductase, sulphotransferases and N-acetyltranferases
skos:notation
RIV/00216208:11310/11:10107363!RIV12-GA0-11310___
n6:predkladatel
n20:orjk%3A11310
n4:aktivita
n13:P n13:Z
n4:aktivity
P(1M0505), P(GA203/09/0812), P(GA303/09/0472), Z(MSM0021620808)
n4:cisloPeriodika
Suppl. 1
n4:dodaniDat
n7:2012
n4:domaciTvurceVysledku
n8:3062465 n8:6846513 n8:8486573 n8:7811160
n4:druhVysledku
n11:J
n4:duvernostUdaju
n18:S
n4:entitaPredkladatele
n19:predkladatel
n4:idSjednocenehoVysledku
191061
n4:idVysledku
RIV/00216208:11310/11:10107363
n4:jazykVysledku
n10:eng
n4:klicovaSlova
molecular modeling; DNA adducts; acetyltransferase; sulfotransferase; NAD(P)H:quinone oxidoreductase; aristolochic acid
n4:klicoveSlovo
n5:DNA%20adducts n5:acetyltransferase n5:NAD%28P%29H%3Aquinone%20oxidoreductase n5:sulfotransferase n5:molecular%20modeling n5:aristolochic%20acid
n4:kodStatuVydavatele
SE - Švédské království
n4:kontrolniKodProRIV
[42029E6842B9]
n4:nazevZdroje
Neuroendocrinology Letters
n4:obor
n17:CE
n4:pocetDomacichTvurcuVysledku
4
n4:pocetTvurcuVysledku
7
n4:projekt
n14:GA203%2F09%2F0812 n14:1M0505 n14:GA303%2F09%2F0472
n4:rokUplatneniVysledku
n7:2011
n4:svazekPeriodika
32
n4:tvurceVysledku
Kubíčková, Božena Frei, Eva Arlt, Volker M. Stiborová, Marie Schmeiser, Heinz H. Hudeček, Jiří Martínek, Václav
n4:zamer
n16:MSM0021620808
s:issn
0172-780X
s:numberOfPages
14
n15:organizacniJednotka
11310