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Statements

Subject Item
n2:RIV%2F00216208%3A11310%2F11%3A10105116%21RIV12-MSM-11310___
rdf:type
skos:Concept n19:Vysledek
rdfs:seeAlso
http://www.bestservis.eu/Rakce/lang
dcterms:description
This work deals with the determination of aminoglutethimide (AGT) using high performance liquid chromatography with UV spectrophotometric detection (HPLC-UV) and amperometric detection (HPLC-ED) on carbon paste electrode (CPE). AGT was used as anticancer drug, especially for the treatment of breast cancer in postmenopausal women or for the treatment of prostate cancer. The concentration dependences of AGT were measured by HPLC-UV with detection wavelength 242 nm, by HPLC-ED with a working potencial of +1.3 V in mobile phase consisting of 1.10-2 mol l-1 phosphate buffer (pH 4) and methanol 50:50 (v/v). The following limits of detection were achieved : 3.6.10-7 mol l-1 AGT for UV spectrophotometric detection, 2.5.10-7 mol l-1 AGT for amperometric detection. AGT was also determined in model samples of urine. It was not possible to detect AGT with HPLC-UV, because of the interferences of other compounds. With HPLC-ED the detection limit 5.2.10-7 mol l-1 AGT was achieved. This work deals with the determination of aminoglutethimide (AGT) using high performance liquid chromatography with UV spectrophotometric detection (HPLC-UV) and amperometric detection (HPLC-ED) on carbon paste electrode (CPE). AGT was used as anticancer drug, especially for the treatment of breast cancer in postmenopausal women or for the treatment of prostate cancer. The concentration dependences of AGT were measured by HPLC-UV with detection wavelength 242 nm, by HPLC-ED with a working potencial of +1.3 V in mobile phase consisting of 1.10-2 mol l-1 phosphate buffer (pH 4) and methanol 50:50 (v/v). The following limits of detection were achieved : 3.6.10-7 mol l-1 AGT for UV spectrophotometric detection, 2.5.10-7 mol l-1 AGT for amperometric detection. AGT was also determined in model samples of urine. It was not possible to detect AGT with HPLC-UV, because of the interferences of other compounds. With HPLC-ED the detection limit 5.2.10-7 mol l-1 AGT was achieved.
dcterms:title
Determination of Aminoglutethimide Using HPLC-ED on CPE Determination of Aminoglutethimide Using HPLC-ED on CPE
skos:prefLabel
Determination of Aminoglutethimide Using HPLC-ED on CPE Determination of Aminoglutethimide Using HPLC-ED on CPE
skos:notation
RIV/00216208:11310/11:10105116!RIV12-MSM-11310___
n19:predkladatel
n20:orjk%3A11310
n3:aktivita
n22:S n22:P n22:Z
n3:aktivity
P(LC06035), P(ME10004), S, Z(MSM0021620857)
n3:dodaniDat
n12:2012
n3:domaciTvurceVysledku
n10:7917244 n10:5768268 n10:6618987 n10:4454472
n3:druhVysledku
n15:D
n3:duvernostUdaju
n24:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
193800
n3:idVysledku
RIV/00216208:11310/11:10105116
n3:jazykVysledku
n11:eng
n3:klicovaSlova
amperometric detection; spectrophotometric detection; HPLC; carbon paste electrode; Aminoglutethimide
n3:klicoveSlovo
n4:spectrophotometric%20detection n4:carbon%20paste%20electrode n4:amperometric%20detection n4:HPLC n4:Aminoglutethimide
n3:kontrolniKodProRIV
[55D50107EB2A]
n3:mistoKonaniAkce
Jetřichovice
n3:mistoVydani
Ústí nad Labem
n3:nazevZdroje
Moderní elektrochemické metody: sborník přednášek XXXI. mezinárodní odborné konference: Jetřichovice 23. – 27. května 2011
n3:obor
n7:CG
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:projekt
n9:ME10004 n9:LC06035
n3:rokUplatneniVysledku
n12:2011
n3:tvurceVysledku
Vlachová, Karolína Zima, Jiří Barek, Jiří Dejmková, Hana
n3:typAkce
n14:EUR
n3:zahajeniAkce
2011-05-23+02:00
n3:zamer
n23:MSM0021620857
s:numberOfPages
4
n16:hasPublisher
BEST servis Ústí nad Labem
n17:isbn
978-80-254-9634-3
n21:organizacniJednotka
11310