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Statements

Subject Item
n2:RIV%2F00216208%3A11310%2F11%3A10104227%21RIV13-MSM-11310___
rdf:type
skos:Concept n10:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1524/ract.2011.1869
dcterms:description
Scandium isotopes ((44)Sc, (47)Sc) are more available and their properties are convenient for either PET imaging or radiotherapy. To use them in nuclear medicine, ligands forming complexes with a high stability are necessary. Available experimental data on stability constants for complexes of ligands such as EDTA, DTPA, DOTA, NOTA and TETA with various metal ions have been published. But scandium is the exception since scarce data is available in the literature. Values of stability constants of Sc(III) with the ligands were determined by free-ion selective radiotracer extraction, complemented by (45)Sc NMR and potentiometry data. The thermodynamic stability of the Sc-complexes increases in the order TETA { NOTA { EDTA { DTPA { DOTA. The in vitro stability of the Sc(III) complexes was studied in the presence of hydroxyapatite and rat serum to estimate their in vivo stability. The most stable complex was shown to be Sc-DOTA. Scandium isotopes ((44)Sc, (47)Sc) are more available and their properties are convenient for either PET imaging or radiotherapy. To use them in nuclear medicine, ligands forming complexes with a high stability are necessary. Available experimental data on stability constants for complexes of ligands such as EDTA, DTPA, DOTA, NOTA and TETA with various metal ions have been published. But scandium is the exception since scarce data is available in the literature. Values of stability constants of Sc(III) with the ligands were determined by free-ion selective radiotracer extraction, complemented by (45)Sc NMR and potentiometry data. The thermodynamic stability of the Sc-complexes increases in the order TETA { NOTA { EDTA { DTPA { DOTA. The in vitro stability of the Sc(III) complexes was studied in the presence of hydroxyapatite and rat serum to estimate their in vivo stability. The most stable complex was shown to be Sc-DOTA.
dcterms:title
Chemical and biological evaluation of scandium(III)-polyaminopolycarboxylate complexes as potential PET agents and radiopharmaceuticals Chemical and biological evaluation of scandium(III)-polyaminopolycarboxylate complexes as potential PET agents and radiopharmaceuticals
skos:prefLabel
Chemical and biological evaluation of scandium(III)-polyaminopolycarboxylate complexes as potential PET agents and radiopharmaceuticals Chemical and biological evaluation of scandium(III)-polyaminopolycarboxylate complexes as potential PET agents and radiopharmaceuticals
skos:notation
RIV/00216208:11310/11:10104227!RIV13-MSM-11310___
n10:predkladatel
n11:orjk%3A11310
n5:aktivita
n17:P n17:I
n5:aktivity
I, P(MEB021041)
n5:cisloPeriodika
10
n5:dodaniDat
n12:2013
n5:domaciTvurceVysledku
n6:9695656 n6:3978877
n5:druhVysledku
n13:J
n5:duvernostUdaju
n21:S
n5:entitaPredkladatele
n18:predkladatel
n5:idSjednocenehoVysledku
190107
n5:idVysledku
RIV/00216208:11310/11:10104227
n5:jazykVysledku
n14:eng
n5:klicovaSlova
positron emission tomography; stability; polyaminocarboxylate ligands; scandium complexes
n5:klicoveSlovo
n9:stability n9:scandium%20complexes n9:polyaminocarboxylate%20ligands n9:positron%20emission%20tomography
n5:kodStatuVydavatele
DE - Spolková republika Německo
n5:kontrolniKodProRIV
[121333941B08]
n5:nazevZdroje
Radiochimica Acta
n5:obor
n19:CA
n5:pocetDomacichTvurcuVysledku
2
n5:pocetTvurcuVysledku
8
n5:projekt
n7:MEB021041
n5:rokUplatneniVysledku
n12:2011
n5:svazekPeriodika
99
n5:tvurceVysledku
Vidaud, C. Ribet, S. Sabatie, A. Paris, M. Cutler, C. S. Hermann, Petr Kubíček, Vojtěch Huclier-Markai, S.
n5:wos
000296081600007
s:issn
0033-8230
s:numberOfPages
10
n16:doi
10.1524/ract.2011.1869
n15:organizacniJednotka
11310