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Statements

Subject Item
n2:RIV%2F00216208%3A11310%2F11%3A10102982%21RIV12-GA0-11310___
rdf:type
skos:Concept n15:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.5562/cca1738
dcterms:description
The goal of the present study was to separate a set of benzodiazepines, namely bromazepam, oxazepam, nitrazepam, chlordiazepoxide, flunitrazepam, lormetazepam and diazepam by analytical scale HPLC and CZE. The both methods for separation of these seven compounds from the 1,4-benzodiazepine group were optimized and compared. LODs and LOQs were determined under the optimized conditions in the both methods. The corresponding LOD and LOQ values are approximately three orders of magnitude lower in HPLC than in CZE. As expected, elution order was found to be different for the both techniques. As a result of a critical collation of all the parameters considered, RP-HPLC was found to be more suitable for determination of the set of benzodiazepines. A real sample analysis was performed under optimized conditions to demonstrate applicability of the proposed analytical methods. The goal of the present study was to separate a set of benzodiazepines, namely bromazepam, oxazepam, nitrazepam, chlordiazepoxide, flunitrazepam, lormetazepam and diazepam by analytical scale HPLC and CZE. The both methods for separation of these seven compounds from the 1,4-benzodiazepine group were optimized and compared. LODs and LOQs were determined under the optimized conditions in the both methods. The corresponding LOD and LOQ values are approximately three orders of magnitude lower in HPLC than in CZE. As expected, elution order was found to be different for the both techniques. As a result of a critical collation of all the parameters considered, RP-HPLC was found to be more suitable for determination of the set of benzodiazepines. A real sample analysis was performed under optimized conditions to demonstrate applicability of the proposed analytical methods.
dcterms:title
Separation and Quantification of 1,4-benzodiazepines: HPLC versus CZE Separation and Quantification of 1,4-benzodiazepines: HPLC versus CZE
skos:prefLabel
Separation and Quantification of 1,4-benzodiazepines: HPLC versus CZE Separation and Quantification of 1,4-benzodiazepines: HPLC versus CZE
skos:notation
RIV/00216208:11310/11:10102982!RIV12-GA0-11310___
n15:predkladatel
n21:orjk%3A11310
n4:aktivita
n13:Z n13:S n13:P
n4:aktivity
P(GA203/08/1428), S, Z(MSM0021620857)
n4:cisloPeriodika
3
n4:dodaniDat
n17:2012
n4:domaciTvurceVysledku
n5:5263344 n5:3984702 n5:4586069 n5:6378935
n4:druhVysledku
n16:J
n4:duvernostUdaju
n9:S
n4:entitaPredkladatele
n12:predkladatel
n4:idSjednocenehoVysledku
228905
n4:idVysledku
RIV/00216208:11310/11:10102982
n4:jazykVysledku
n19:eng
n4:klicovaSlova
pharmaceuticals; benzodiazepines; CZE; RP-HPLC
n4:klicoveSlovo
n11:benzodiazepines n11:pharmaceuticals n11:CZE n11:RP-HPLC
n4:kodStatuVydavatele
HR - Chorvatská republika
n4:kontrolniKodProRIV
[16B8F8C7CBB2]
n4:nazevZdroje
Croatica Chemica Acta
n4:obor
n7:CB
n4:pocetDomacichTvurcuVysledku
4
n4:pocetTvurcuVysledku
5
n4:projekt
n22:GA203%2F08%2F1428
n4:rokUplatneniVysledku
n17:2011
n4:svazekPeriodika
84
n4:tvurceVysledku
Chudoba, Richard Kalíková, Květa Riesová, Martina Schmid, Martin G. Tesařová, Eva
n4:wos
000298934200006
n4:zamer
n14:MSM0021620857
s:issn
0011-1643
s:numberOfPages
7
n18:doi
10.5562/cca1738
n20:organizacniJednotka
11310