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Statements

Subject Item
n2:RIV%2F00216208%3A11310%2F10%3A10081988%21RIV11-MSM-11310___
rdf:type
n8:Vysledek skos:Concept
dcterms:description
Lactate and alanine concentration measurement is useful first-line tool in assessing children with suspected mitochondrial disorders. : Our data indicate that examination of B- and CSF-lactate levels can be considered as a determinant of mitochondrial disorders, with an ability to distinguish these patients from the epileptic ones. Our results suggest that there is no effect of short-period tonic-clonic seizures on the significant raise of B-and CSF-lactate concentrations. Determination of alanine levels also has a high specificity to distinguish between mitochondrial and other multisystem disorders. Lactate and alanine concentration measurement is useful first-line tool in assessing children with suspected mitochondrial disorders. : Our data indicate that examination of B- and CSF-lactate levels can be considered as a determinant of mitochondrial disorders, with an ability to distinguish these patients from the epileptic ones. Our results suggest that there is no effect of short-period tonic-clonic seizures on the significant raise of B-and CSF-lactate concentrations. Determination of alanine levels also has a high specificity to distinguish between mitochondrial and other multisystem disorders.
dcterms:title
Elevated lactate is a reliable marker pointing to mitochondrial disorders even in children after brief seizures. Elevated lactate is a reliable marker pointing to mitochondrial disorders even in children after brief seizures.
skos:prefLabel
Elevated lactate is a reliable marker pointing to mitochondrial disorders even in children after brief seizures. Elevated lactate is a reliable marker pointing to mitochondrial disorders even in children after brief seizures.
skos:notation
RIV/00216208:11310/10:10081988!RIV11-MSM-11310___
n4:aktivita
n14:Z n14:S
n4:aktivity
S, Z(MSM0021620806)
n4:cisloPeriodika
Neuveden
n4:dodaniDat
n13:2011
n4:domaciTvurceVysledku
n9:6581102
n4:druhVysledku
n17:J
n4:duvernostUdaju
n11:S
n4:entitaPredkladatele
n18:predkladatel
n4:idSjednocenehoVysledku
256898
n4:idVysledku
RIV/00216208:11310/10:10081988
n4:jazykVysledku
n16:eng
n4:klicovaSlova
seizures.; brief; after; children; even; disorders; mitochondrial; pointing; marker; reliable; lactate; Elevated
n4:klicoveSlovo
n7:children n7:Elevated n7:even n7:lactate n7:mitochondrial n7:after n7:marker n7:brief n7:pointing n7:seizures. n7:reliable n7:disorders
n4:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n4:kontrolniKodProRIV
[0C8DFF789F9C]
n4:nazevZdroje
European Journal of Paediatric Neurology
n4:obor
n10:FH
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
7
n4:rokUplatneniVysledku
n13:2010
n4:svazekPeriodika
2010
n4:tvurceVysledku
Honzík, Tomáš Szentiványi, Karol Zeman, Jiří Švandová, Ivana Tesařová, Markéta Ješina, Pavel Magner, Martin
n4:zamer
n5:MSM0021620806
s:issn
1090-3798
s:numberOfPages
8
n12:organizacniJednotka
11310