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Statements

Subject Item
n2:RIV%2F00216208%3A11310%2F10%3A10081189%21RIV11-MSM-11310___
rdf:type
n10:Vysledek skos:Concept
dcterms:description
The results demonstrate that Leishmania gut binding is strictly stage-dependent, is a property of those forms found in the middle phase of development (nectomonad and leptomonad forms), but is absent in the early blood meal and final stages (procyclic and metacyclic forms). Further they show that although gut binding may be necessary for parasite establishment, in several vector-parasite pairs the specificity of such in vitro binding alone is insufficient to explain overall vector specificity. Other significant barriers to development must exist in certain refractory Leishmania parasite-sand fly vector combinations. A re-appraisal of the specificity of the Leishmania-sand fly relationship is required. The results demonstrate that Leishmania gut binding is strictly stage-dependent, is a property of those forms found in the middle phase of development (nectomonad and leptomonad forms), but is absent in the early blood meal and final stages (procyclic and metacyclic forms). Further they show that although gut binding may be necessary for parasite establishment, in several vector-parasite pairs the specificity of such in vitro binding alone is insufficient to explain overall vector specificity. Other significant barriers to development must exist in certain refractory Leishmania parasite-sand fly vector combinations. A re-appraisal of the specificity of the Leishmania-sand fly relationship is required.
dcterms:title
Stage-Specific Adhesion of Leishmania Promastigotes to Sand Fly Midguts Assessed Using an Improved Comparative Binding Assay Stage-Specific Adhesion of Leishmania Promastigotes to Sand Fly Midguts Assessed Using an Improved Comparative Binding Assay
skos:prefLabel
Stage-Specific Adhesion of Leishmania Promastigotes to Sand Fly Midguts Assessed Using an Improved Comparative Binding Assay Stage-Specific Adhesion of Leishmania Promastigotes to Sand Fly Midguts Assessed Using an Improved Comparative Binding Assay
skos:notation
RIV/00216208:11310/10:10081189!RIV11-MSM-11310___
n3:aktivita
n6:P n6:Z
n3:aktivity
P(LC06009), Z(MSM0021620828)
n3:cisloPeriodika
9
n3:dodaniDat
n15:2011
n3:domaciTvurceVysledku
n9:6447910 n9:3660079 n9:1007793
n3:druhVysledku
n16:J
n3:duvernostUdaju
n11:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
289623
n3:idVysledku
RIV/00216208:11310/10:10081189
n3:jazykVysledku
n17:eng
n3:klicovaSlova
PSYCHODIDAE; FLIES; TRANSMISSION; LIFE-CYCLE; VECTORIAL COMPETENCE; MAJOR LIPOPHOSPHOGLYCAN; SURFACE LIPOPHOSPHOGLYCAN; DEVELOPMENTAL MODIFICATION; PHLEBOTOMUS-PAPATASI; LUTZOMYIA-LONGIPALPIS DIPTERA
n3:klicoveSlovo
n8:LUTZOMYIA-LONGIPALPIS%20DIPTERA n8:DEVELOPMENTAL%20MODIFICATION n8:FLIES n8:PHLEBOTOMUS-PAPATASI n8:TRANSMISSION n8:PSYCHODIDAE n8:SURFACE%20LIPOPHOSPHOGLYCAN n8:MAJOR%20LIPOPHOSPHOGLYCAN n8:LIFE-CYCLE n8:VECTORIAL%20COMPETENCE
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[C08A151674B5]
n3:nazevZdroje
PLoS Neglected Tropical Diseases
n3:obor
n13:EE
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
7
n3:projekt
n4:LC06009
n3:rokUplatneniVysledku
n15:2010
n3:svazekPeriodika
4
n3:tvurceVysledku
Dostálová, Anna Dillon, Rod Volf, Petr Bates, Michelle Wilson, Raymond Ječná, Lucie Bates, Paul
n3:wos
000282271300019
n3:zamer
n19:MSM0021620828
s:issn
1935-2727
s:numberOfPages
9
n5:organizacniJednotka
11310