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Statements

Subject Item
n2:RIV%2F00216208%3A11310%2F10%3A10080553%21RIV11-MSM-11310___
rdf:type
skos:Concept n12:Vysledek
dcterms:description
Background: Trichomonas vaginalis is the most common non-viral human sexually transmitted pathogen and importantly, contributes to facilitating the spread of HIV. Yet very little is known about its surface and secreted proteins mediating interactions with, and permitting the invasion and colonisation of, the host mucosa. Initial annotations of T. vaginalis genome identified a plethora of candidate extracellular proteins. Results: Data mining of the T. vaginalis genome identified 911 BspA-like entries (TvBspA) sharing TpLRR-like leucine-rich repeats, which represent the largest gene family encoding potential extracellular proteins for the pathogen. A broad range of microorganisms encoding BspA-like proteins was identified and these are mainly known to live on mucosal surfaces, among these T. vaginalis is endowed with the largest gene family. Background: Trichomonas vaginalis is the most common non-viral human sexually transmitted pathogen and importantly, contributes to facilitating the spread of HIV. Yet very little is known about its surface and secreted proteins mediating interactions with, and permitting the invasion and colonisation of, the host mucosa. Initial annotations of T. vaginalis genome identified a plethora of candidate extracellular proteins. Results: Data mining of the T. vaginalis genome identified 911 BspA-like entries (TvBspA) sharing TpLRR-like leucine-rich repeats, which represent the largest gene family encoding potential extracellular proteins for the pathogen. A broad range of microorganisms encoding BspA-like proteins was identified and these are mainly known to live on mucosal surfaces, among these T. vaginalis is endowed with the largest gene family.
dcterms:title
Trichomonas vaginalis vast BspA-like gene family: evidence for functional diversity from structural organisation and transcriptomics Trichomonas vaginalis vast BspA-like gene family: evidence for functional diversity from structural organisation and transcriptomics
skos:prefLabel
Trichomonas vaginalis vast BspA-like gene family: evidence for functional diversity from structural organisation and transcriptomics Trichomonas vaginalis vast BspA-like gene family: evidence for functional diversity from structural organisation and transcriptomics
skos:notation
RIV/00216208:11310/10:10080553!RIV11-MSM-11310___
n3:aktivita
n4:P n4:Z
n3:aktivity
P(LC07032), Z(MSM0021620858)
n3:cisloPeriodika
-
n3:dodaniDat
n10:2011
n3:domaciTvurceVysledku
n13:7444133 n13:9972293
n3:druhVysledku
n5:J
n3:duvernostUdaju
n9:S
n3:entitaPredkladatele
n11:predkladatel
n3:idSjednocenehoVysledku
293606
n3:idVysledku
RIV/00216208:11310/10:10080553
n3:jazykVysledku
n19:eng
n3:klicovaSlova
virulence factors; clostridium-difficile; molecular characterization; epithelial-cells; entamoeba-histolytica; tannerella-forsythia; amino-acid repeats; signal peptide prediction; combined transmembrane topology; Leucine-rich-repeat
n3:klicoveSlovo
n6:combined%20transmembrane%20topology n6:clostridium-difficile n6:entamoeba-histolytica n6:signal%20peptide%20prediction n6:epithelial-cells n6:Leucine-rich-repeat n6:virulence%20factors n6:tannerella-forsythia n6:amino-acid%20repeats n6:molecular%20characterization
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[2A8D3748F8A4]
n3:nazevZdroje
BMC Genomics
n3:obor
n15:EE
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
8
n3:projekt
n17:LC07032
n3:rokUplatneniVysledku
n10:2010
n3:svazekPeriodika
11
n3:tvurceVysledku
Hirt, Robert P. Sicheritz-Ponten, Thomas Tang, Petrus Šafaříková, Lucie Diaz, Nicia Tachezy, Jan Noel, Christophe J. Fiori, Pier-Luigi
n3:wos
000275835100001
n3:zamer
n8:MSM0021620858
s:issn
1471-2164
s:numberOfPages
26
n16:organizacniJednotka
11310