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Statements

Subject Item
n2:RIV%2F00216208%3A11310%2F10%3A10051989%21RIV11-GA0-11310___
rdf:type
skos:Concept n19:Vysledek
dcterms:description
In magnetic resonance imaging (MRI), paramagnetic complexes are utilized as contrast agents. Much attention has been paid to the development of new contrast agents responsive to pH, temperature or concentration of various components of body liquids. We report a new type of MRI probe sensing the concentrations of calcium and magnesium in biological media. The ligand do3ap(BP) combines a dota-like chelator with a bisphosphonate group. In the complex, the Gd(III) ion is entrapped in the macrocyclic cavity whereas the bisphosphonate group is not coordinated and therefore is available for coordination with endogenous metal ions. In the presence of metal ions, Gd-do3ap(BP) appears to show formation of coordination oligomers leading to an unprecedented increase in r(1) up to 200-500%. The extremely high relaxivity response makes this type of compound interesting for further studies as MRI ion-responsive probes for biomedical research. In magnetic resonance imaging (MRI), paramagnetic complexes are utilized as contrast agents. Much attention has been paid to the development of new contrast agents responsive to pH, temperature or concentration of various components of body liquids. We report a new type of MRI probe sensing the concentrations of calcium and magnesium in biological media. The ligand do3ap(BP) combines a dota-like chelator with a bisphosphonate group. In the complex, the Gd(III) ion is entrapped in the macrocyclic cavity whereas the bisphosphonate group is not coordinated and therefore is available for coordination with endogenous metal ions. In the presence of metal ions, Gd-do3ap(BP) appears to show formation of coordination oligomers leading to an unprecedented increase in r(1) up to 200-500%. The extremely high relaxivity response makes this type of compound interesting for further studies as MRI ion-responsive probes for biomedical research.
dcterms:title
Towards MRI contrast agents responsive to Ca(II) and Mg(II) ions: Metal-induced oligomerization of dota-bisphosphonate conjugates Towards MRI contrast agents responsive to Ca(II) and Mg(II) ions: Metal-induced oligomerization of dota-bisphosphonate conjugates
skos:prefLabel
Towards MRI contrast agents responsive to Ca(II) and Mg(II) ions: Metal-induced oligomerization of dota-bisphosphonate conjugates Towards MRI contrast agents responsive to Ca(II) and Mg(II) ions: Metal-induced oligomerization of dota-bisphosphonate conjugates
skos:notation
RIV/00216208:11310/10:10051989!RIV11-GA0-11310___
n3:aktivita
n5:R n5:P n5:Z
n3:aktivity
P(GA203/09/1056), P(KAN201110651), P(OC 179), R, Z(MSM0021620857)
n3:cisloPeriodika
5
n3:dodaniDat
n6:2011
n3:domaciTvurceVysledku
n7:3978877 n7:3062228 n7:4410467 n7:9417850 n7:9695656
n3:druhVysledku
n8:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
293136
n3:idVysledku
RIV/00216208:11310/10:10051989
n3:jazykVysledku
n17:eng
n3:klicovaSlova
responsive agents; bisphosphonate; gadolinium complexes; MRI
n3:klicoveSlovo
n4:MRI n4:responsive%20agents n4:gadolinium%20complexes n4:bisphosphonate
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[3B228D323E9E]
n3:nazevZdroje
Contrast Media and Molecular Imaging
n3:obor
n16:CA
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
8
n3:projekt
n11:OC%20179 n11:KAN201110651 n11:GA203%2F09%2F1056
n3:rokUplatneniVysledku
n6:2010
n3:svazekPeriodika
5
n3:tvurceVysledku
Hermann, Petr Kubíček, Vojtěch Kotek, Jan Vander Elst, Luce Peters, Joop A. Lukeš, Ivan Vitha, Tomáš Muller, Robert N.
n3:wos
000283641900006
n3:zamer
n18:MSM0021620857
s:issn
1555-4309
s:numberOfPages
3
n15:organizacniJednotka
11310