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Statements

Subject Item
n2:RIV%2F00216208%3A11310%2F09%3A10000814%21RIV10-GA0-11310___
rdf:type
skos:Concept n15:Vysledek
dcterms:description
A highly enantioselective organocatalytic synthesis of piperidines is reported. The reaction is catalyzed by simple and commercially available secondary amines, affording the corresponding adducts with high yields and enantioselectivities. Moreover, this reaction is used for the formal synthesis of (-)-Paroxetine, a blockbuster drug, in only three steps. A highly enantioselective organocatalytic synthesis of piperidines is reported. The reaction is catalyzed by simple and commercially available secondary amines, affording the corresponding adducts with high yields and enantioselectivities. Moreover, this reaction is used for the formal synthesis of (-)-Paroxetine, a blockbuster drug, in only three steps.
dcterms:title
Highly enantioselective organocatalytic synthesis of piperidines. Formal synthesis of (-)-Paroxetine Highly enantioselective organocatalytic synthesis of piperidines. Formal synthesis of (-)-Paroxetine
skos:prefLabel
Highly enantioselective organocatalytic synthesis of piperidines. Formal synthesis of (-)-Paroxetine Highly enantioselective organocatalytic synthesis of piperidines. Formal synthesis of (-)-Paroxetine
skos:notation
RIV/00216208:11310/09:10000814!RIV10-GA0-11310___
n5:aktivita
n7:Z n7:P
n5:aktivity
P(GP203/09/P193), Z(MSM0021620857)
n5:cisloPeriodika
17
n5:dodaniDat
n10:2010
n5:domaciTvurceVysledku
n14:5534305 n14:3157962 n14:4297598
n5:druhVysledku
n17:J
n5:duvernostUdaju
n19:S
n5:entitaPredkladatele
n11:predkladatel
n5:idSjednocenehoVysledku
317155
n5:idVysledku
RIV/00216208:11310/09:10000814
n5:jazykVysledku
n12:eng
n5:klicovaSlova
Highly; enantioselective; organocatalytic; synthesis; piperidines.; Formal; synthesis; (-)-Paroxetine
n5:klicoveSlovo
n6:enantioselective n6:organocatalytic n6:Formal n6:Highly n6:synthesis n6:piperidines. n6:%28-%29-Paroxetine
n5:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n5:kontrolniKodProRIV
[1A300E9CD78E]
n5:nazevZdroje
Tetrahedron Letters
n5:obor
n18:CC
n5:pocetDomacichTvurcuVysledku
3
n5:pocetTvurcuVysledku
6
n5:projekt
n13:GP203%2F09%2FP193
n5:rokUplatneniVysledku
n10:2009
n5:svazekPeriodika
50
n5:tvurceVysledku
Valero, Guillem Moyano, Albert Císařová, Ivana Schimer, Jiří Veselý, Jan Rios, Ramon
n5:wos
000264954000017
n5:zamer
n16:MSM0021620857
s:issn
0040-4039
s:numberOfPages
4
n9:organizacniJednotka
11310