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Statements

Subject Item
n2:RIV%2F00216208%3A11310%2F09%3A10000179%21RIV10-GA0-11310___
rdf:type
n11:Vysledek skos:Concept
dcterms:description
Both carcinogens, o-anisidine and 2-nitroanisole, are activated to the same proximate carcinogenic metabolite, N-(2-methoxyphenyl)hydroxylamine, which spontaneously decomposes to nitrenium and/or carbenium ions responsible for formation of deoxyguanosine adducts in DNA in vitro and in vivo. Both carcinogens, o-anisidine and 2-nitroanisole, are activated to the same proximate carcinogenic metabolite, N-(2-methoxyphenyl)hydroxylamine, which spontaneously decomposes to nitrenium and/or carbenium ions responsible for formation of deoxyguanosine adducts in DNA in vitro and in vivo.
dcterms:title
Genotoxic mechanisms for the carcinogenicity of the environmental pollutants and carcinogens o-anisidine and 2-nitroanisole follow from adducts generated by their metabolite N-(2-methoxyphenyl)-hydroxylamine with deoxyguanosine in DNA Genotoxic mechanisms for the carcinogenicity of the environmental pollutants and carcinogens o-anisidine and 2-nitroanisole follow from adducts generated by their metabolite N-(2-methoxyphenyl)-hydroxylamine with deoxyguanosine in DNA
skos:prefLabel
Genotoxic mechanisms for the carcinogenicity of the environmental pollutants and carcinogens o-anisidine and 2-nitroanisole follow from adducts generated by their metabolite N-(2-methoxyphenyl)-hydroxylamine with deoxyguanosine in DNA Genotoxic mechanisms for the carcinogenicity of the environmental pollutants and carcinogens o-anisidine and 2-nitroanisole follow from adducts generated by their metabolite N-(2-methoxyphenyl)-hydroxylamine with deoxyguanosine in DNA
skos:notation
RIV/00216208:11310/09:10000179!RIV10-GA0-11310___
n4:aktivita
n8:Z n8:S n8:P
n4:aktivity
P(1M0505), P(GA203/09/0812), P(GA303/09/0472), S, Z(MSM0021620808)
n4:cisloPeriodika
1
n4:dodaniDat
n10:2010
n4:domaciTvurceVysledku
n17:9806008 n17:1850334 n17:8486573 n17:4655036 n17:3062465
n4:druhVysledku
n18:J
n4:duvernostUdaju
n6:S
n4:entitaPredkladatele
n13:predkladatel
n4:idSjednocenehoVysledku
316215
n4:idVysledku
RIV/00216208:11310/09:10000179
n4:jazykVysledku
n16:eng
n4:klicovaSlova
genotoxic mechanism; carcinogenicity; environmental pollutant; carcinogen; o-anisidine; 2-nitroanisole; adduct; metabolite; N-(2-methoxyphenyl)-hydroxylamine; deoxyguanosine; DNA
n4:klicoveSlovo
n5:environmental%20pollutant n5:deoxyguanosine n5:N-%282-methoxyphenyl%29-hydroxylamine n5:DNA n5:genotoxic%20mechanism n5:metabolite n5:carcinogen n5:adduct n5:2-nitroanisole n5:o-anisidine n5:carcinogenicity
n4:kodStatuVydavatele
SK - Slovenská republika
n4:kontrolniKodProRIV
[12E8877F9946]
n4:nazevZdroje
Interdisciplinary Toxicology
n4:obor
n15:CE
n4:pocetDomacichTvurcuVysledku
5
n4:pocetTvurcuVysledku
7
n4:projekt
n9:GA203%2F09%2F0812 n9:1M0505 n9:GA303%2F09%2F0472
n4:rokUplatneniVysledku
n10:2009
n4:svazekPeriodika
2
n4:tvurceVysledku
Schmeiser, Heinz H. Svobodová, Martina Martínková, Markéta Naiman, Karel Frei, Eva Stiborová, Marie Martínek, Václav
n4:zamer
n14:MSM0021620808
s:issn
1337-6853
s:numberOfPages
4
n19:organizacniJednotka
11310