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Statements

Subject Item
n2:RIV%2F00216208%3A11310%2F09%3A10000029%21RIV10-GA0-11310___
rdf:type
skos:Concept n19:Vysledek
dcterms:description
The recombinant cathepsin B2 from Trichobilharzia regenti was produced and characterised. Its presence was confirmed in extracts from cercariae and schistosomula. Cross-reactivity was observed between T. regenti and S. mansoni cathepsins B2 in extracts of cercariae, schistosomula or adults. In T. regenti, the antisera localised the enzyme to post-acetabular penetration glands of cercariae implying an important role in the penetration of host skin. Elastinolytic activity suggests that the enzyme might functionally substitute the histolytic role of the serine class elastase known from S. mansoni and Schistosoma haematobium. The recombinant cathepsin B2 from Trichobilharzia regenti was produced and characterised. Its presence was confirmed in extracts from cercariae and schistosomula. Cross-reactivity was observed between T. regenti and S. mansoni cathepsins B2 in extracts of cercariae, schistosomula or adults. In T. regenti, the antisera localised the enzyme to post-acetabular penetration glands of cercariae implying an important role in the penetration of host skin. Elastinolytic activity suggests that the enzyme might functionally substitute the histolytic role of the serine class elastase known from S. mansoni and Schistosoma haematobium.
dcterms:title
The functional expression and characterisation of a cysteine peptidase from the invasive stage of the neuropathogenic schistosome Trichobilharzia regenti The functional expression and characterisation of a cysteine peptidase from the invasive stage of the neuropathogenic schistosome Trichobilharzia regenti
skos:prefLabel
The functional expression and characterisation of a cysteine peptidase from the invasive stage of the neuropathogenic schistosome Trichobilharzia regenti The functional expression and characterisation of a cysteine peptidase from the invasive stage of the neuropathogenic schistosome Trichobilharzia regenti
skos:notation
RIV/00216208:11310/09:10000029!RIV10-GA0-11310___
n3:aktivita
n12:P n12:Z
n3:aktivity
P(GA206/07/0233), P(GP524/04/P082), P(LC06009), Z(MSM0021620828)
n3:cisloPeriodika
2
n3:dodaniDat
n17:2010
n3:domaciTvurceVysledku
n5:9686444 n5:8515743 n5:9477144 n5:1604422 n5:5321786
n3:druhVysledku
n9:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
315713
n3:idVysledku
RIV/00216208:11310/09:10000029
n3:jazykVysledku
n7:eng
n3:klicovaSlova
Trematoda; cathepsin B; protease; penetration gland; skin; histolysis; Schistosoma; Trichobilharzia; cercaria
n3:klicoveSlovo
n4:histolysis n4:protease n4:penetration%20gland n4:skin n4:cathepsin%20B n4:Trematoda n4:Schistosoma n4:Trichobilharzia n4:cercaria
n3:kodStatuVydavatele
AU - Australské společenství
n3:kontrolniKodProRIV
[1C0E9B8CF7D9]
n3:nazevZdroje
International Journal for Parasitology
n3:obor
n6:CE
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
10
n3:projekt
n11:LC06009 n11:GP524%2F04%2FP082 n11:GA206%2F07%2F0233
n3:rokUplatneniVysledku
n17:2009
n3:svazekPeriodika
39
n3:tvurceVysledku
Dolečková, Kateřina Craik, Charles S. Mikeš, Libor Jedelský, Petr Horák, Petr Kašný, Martin Dvořák, Jan Schneider, Eric L. Mountford, Adrian P. Cartwright, Jared
n3:wos
000262770200008
n3:zamer
n10:MSM0021620828
s:issn
0020-7519
s:numberOfPages
11
n15:organizacniJednotka
11310