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Statements

Subject Item
n2:RIV%2F00216208%3A11310%2F08%3A13541%21RIV09-MSM-11310___
rdf:type
skos:Concept n18:Vysledek
dcterms:description
Ellipticin tvoří kovalentní adukty s DNA, po aktivaci cvytochromy P450 a peroxidasami. Byla porovnána role jaterního a mimojaterního metabolismu použitím s cytochrom P450 reduktaza deficientního myšího modelu. Ellipticine is an antineoplastic agent, which forms covalent DNA adducts mediated by cytochromes P450 and peroxidases. We evaluated the role of hepatic versus extra-hepatic metabolism of ellipticine, using the Hepatic Cytochrome P450 Reductase Null mouse Ellipticine is an antineoplastic agent, which forms covalent DNA adducts mediated by cytochromes P450 and peroxidases. We evaluated the role of hepatic versus extra-hepatic metabolism of ellipticine, using the Hepatic Cytochrome P450 Reductase Null mouse
dcterms:title
Role jaterních cytochromů P450 při biotransformaci protinádorového léčiva ellipticinu Role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine: Studies with the hepatic NADPH: Cytochrome P450 reductase null mouse Role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine: Studies with the hepatic NADPH: Cytochrome P450 reductase null mouse
skos:prefLabel
Role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine: Studies with the hepatic NADPH: Cytochrome P450 reductase null mouse Role jaterních cytochromů P450 při biotransformaci protinádorového léčiva ellipticinu Role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine: Studies with the hepatic NADPH: Cytochrome P450 reductase null mouse
skos:notation
RIV/00216208:11310/08:13541!RIV09-MSM-11310___
n5:aktivita
n12:Z n12:P
n5:aktivity
P(1M0505), P(GA203/06/0329), Z(MSM0021620808)
n5:cisloPeriodika
3
n5:dodaniDat
n9:2009
n5:domaciTvurceVysledku
n10:8486573 n10:6798055 n10:1070177 n10:7811160
n5:druhVysledku
n17:J
n5:duvernostUdaju
n14:S
n5:entitaPredkladatele
n19:predkladatel
n5:idSjednocenehoVysledku
393184
n5:idVysledku
RIV/00216208:11310/08:13541
n5:jazykVysledku
n7:eng
n5:klicovaSlova
anticancer drug; ellipticine; cytochrome P450; peroxidase; DNA adducts; P-32-postlabelling; dna adduct formation; prostaglandin-h synthase; environmental-pollutant 3-nitrobenzanthrone; metabolic-activation; determines susceptibility; xenobiotic-metabolism; liver-microsomes; oxidation; enzymes; mice
n5:klicoveSlovo
n6:liver-microsomes n6:oxidation n6:ellipticine n6:DNA%20adducts n6:anticancer%20drug n6:mice n6:xenobiotic-metabolism n6:metabolic-activation n6:environmental-pollutant%203-nitrobenzanthrone n6:dna%20adduct%20formation n6:peroxidase n6:prostaglandin-h%20synthase n6:determines%20susceptibility n6:cytochrome%20P450 n6:P-32-postlabelling n6:enzymes
n5:kodStatuVydavatele
US - Spojené státy americké
n5:kontrolniKodProRIV
[099F5ECDF8B8]
n5:nazevZdroje
Toxicology and applied pharmacology
n5:obor
n16:CE
n5:pocetDomacichTvurcuVysledku
4
n5:pocetTvurcuVysledku
9
n5:projekt
n11:1M0505 n11:GA203%2F06%2F0329
n5:rokUplatneniVysledku
n9:2008
n5:svazekPeriodika
226
n5:tvurceVysledku
Hudeček, Jiří Kotrbová, Věra Stiborová, Marie Moserová, Michaela
n5:wos
000253002200011
n5:zamer
n15:MSM0021620808
s:issn
0041-008X
s:numberOfPages
10
n13:organizacniJednotka
11310