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Statements

Subject Item
n2:RIV%2F00216208%3A11310%2F08%3A13224%21RIV12-GA0-11310___
rdf:type
skos:Concept n21:Vysledek
rdfs:seeAlso
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-3024.2008.01059.x/full
dcterms:description
Cercariae of bird schistosomes (genus Trichobilharzia) are able to penetrate the skin of mammals (noncompatible hosts), including humans, and cause a Th2-associated inflammatory cutaneous reaction termed cercarial dermatitis. The present study measured the antibody reactivity and antigen specificity of sera obtained after experimental infection of mice and natural infection of humans. Sera from mice re-infected with T. regenti showed a bias towards the development of antigen-specific IgM and IgG1 antibodies and elevated levels of total serum IgE, indicative of a Th2 polarized immune response. We also demonstrate that cercariae are a source of antigens triggering IL-4 release from basophils collected from healthy human volunteers. Analysis of sera from patients with a history of cercarial dermatitis revealed elevated levels of cercarial-specific IgG, particularly for samples collected from adults (} 14 years old) compared with children (8-14 years old), although elevated levels of antigenspecific IgE were not detected. In terms of antigen recognition, IgG and IgE antibodies in the sera of both mice and humans preferentially bound an antigen of 34 kDa. The 34 kDa molecule was present in both homogenate of cercariae, as well as cercarial excretory/secretory products, and we speculate it may represent a major immunogen initiating the Th2-immune response associated with cercarial dermatitis. Cercariae of bird schistosomes (genus Trichobilharzia) are able to penetrate the skin of mammals (noncompatible hosts), including humans, and cause a Th2-associated inflammatory cutaneous reaction termed cercarial dermatitis. The present study measured the antibody reactivity and antigen specificity of sera obtained after experimental infection of mice and natural infection of humans. Sera from mice re-infected with T. regenti showed a bias towards the development of antigen-specific IgM and IgG1 antibodies and elevated levels of total serum IgE, indicative of a Th2 polarized immune response. We also demonstrate that cercariae are a source of antigens triggering IL-4 release from basophils collected from healthy human volunteers. Analysis of sera from patients with a history of cercarial dermatitis revealed elevated levels of cercarial-specific IgG, particularly for samples collected from adults (} 14 years old) compared with children (8-14 years old), although elevated levels of antigenspecific IgE were not detected. In terms of antigen recognition, IgG and IgE antibodies in the sera of both mice and humans preferentially bound an antigen of 34 kDa. The 34 kDa molecule was present in both homogenate of cercariae, as well as cercarial excretory/secretory products, and we speculate it may represent a major immunogen initiating the Th2-immune response associated with cercarial dermatitis.
dcterms:title
Antibody responses induced by Trichobilharzia regenti antigens in murine and human hosts exhibiting cercarial dermatitis Antibody responses induced by Trichobilharzia regenti antigens in murine and human hosts exhibiting cercarial dermatitis
skos:prefLabel
Antibody responses induced by Trichobilharzia regenti antigens in murine and human hosts exhibiting cercarial dermatitis Antibody responses induced by Trichobilharzia regenti antigens in murine and human hosts exhibiting cercarial dermatitis
skos:notation
RIV/00216208:11310/08:13224!RIV12-GA0-11310___
n3:aktivita
n14:P n14:Z
n3:aktivity
P(GA206/06/0777), P(GA206/07/0233), P(LC06009), Z(MSM0021620828)
n3:cisloPeriodika
11-12
n3:dodaniDat
n19:2012
n3:domaciTvurceVysledku
n6:5321786 n6:4443225 n6:1604422 n6:9477144
n3:druhVysledku
n15:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n11:predkladatel
n3:idSjednocenehoVysledku
356402
n3:idVysledku
RIV/00216208:11310/08:13224
n3:jazykVysledku
n9:eng
n3:klicovaSlova
Trichobilharzia; schistosomes; IgE; cathepsin; Antibody
n3:klicoveSlovo
n8:Antibody n8:schistosomes n8:cathepsin n8:IgE n8:Trichobilharzia
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[33FEF646D948]
n3:nazevZdroje
Parasite Immunology
n3:obor
n16:EC
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
10
n3:projekt
n4:LC06009 n4:GA206%2F07%2F0233 n4:GA206%2F06%2F0777
n3:rokUplatneniVysledku
n19:2008
n3:svazekPeriodika
30
n3:tvurceVysledku
Mikeš, Libor Kouřilová, Pavlína Kolbeková, Petra Haas, Helmut Horák, Petr Kašný, Martin Schramm, Gabriele Kolářová, Libuše Lichtenbergová, Lucie Mountford, Adrian P.
n3:wos
000260540900003
n3:zamer
n10:MSM0021620828
s:issn
0141-9838
s:numberOfPages
11
n13:doi
10.1111/j.1365-3024.2008.01059.x
n17:organizacniJednotka
11310