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Statements

Subject Item
n2:RIV%2F00216208%3A11310%2F05%3A8056%21RIV08-AV0-11310___
rdf:type
skos:Concept n18:Vysledek
dcterms:description
Functional analysis of selected mutants of the alpha(1b)-AR and Galpha(11) protein co-expressed in HEK-293 cells revealed that palmitoylation of the receptor does not regulate cognate G protein activation but palmitoylation of Galpha(11) is important. Analýza funkčních vlastností vybraných mutant alfa(1b)-AR a Galfa(11) proteinu exprimovaných v HEK-293 buňkách odhalila, že palmitoylace receptoru neovlivňuje aktivaci příslušného G proteinu, ale palmitoylace Galfa(11) je důležitá v přenosu signálu. Functional analysis of selected mutants of the alpha(1b)-AR and Galpha(11) protein co-expressed in HEK-293 cells revealed that palmitoylation of the receptor does not regulate cognate G protein activation but palmitoylation of Galpha(11) is important.
dcterms:title
Functional interactions between the alpha(1b)-adrenoceptor and Galpha(11) are compromised by de-palmitoylation of the G protein but not of the receptor. Functional interactions between the alpha(1b)-adrenoceptor and Galpha(11) are compromised by de-palmitoylation of the G protein but not of the receptor. Funkční interakce mezi alfa(1b)-adrenoceptorem a Galfa(11) jsou ohroženy depalmitoylací G proteinu, ale nikoliv receptoru.
skos:prefLabel
Funkční interakce mezi alfa(1b)-adrenoceptorem a Galfa(11) jsou ohroženy depalmitoylací G proteinu, ale nikoliv receptoru. Functional interactions between the alpha(1b)-adrenoceptor and Galpha(11) are compromised by de-palmitoylation of the G protein but not of the receptor. Functional interactions between the alpha(1b)-adrenoceptor and Galpha(11) are compromised by de-palmitoylation of the G protein but not of the receptor.
skos:notation
RIV/00216208:11310/05:8056!RIV08-AV0-11310___
n4:strany
1-8
n4:aktivita
n15:Z
n4:aktivity
Z(AV0Z5011922)
n4:cisloPeriodika
1
n4:dodaniDat
n14:2008
n4:domaciTvurceVysledku
n8:6134343 n8:3710769 n8:8184658
n4:druhVysledku
n17:J
n4:duvernostUdaju
n16:S
n4:entitaPredkladatele
n6:predkladatel
n4:idSjednocenehoVysledku
522224
n4:idVysledku
RIV/00216208:11310/05:8056
n4:jazykVysledku
n12:eng
n4:klicovaSlova
Palmitoylation; alpha(1b)-adrenoceptor; G protein
n4:klicoveSlovo
n13:G%20protein n13:Palmitoylation n13:alpha%281b%29-adrenoceptor
n4:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n4:kontrolniKodProRIV
[6EFE9164B65C]
n4:nazevZdroje
Cellular Signalling
n4:obor
n10:CE
n4:pocetDomacichTvurcuVysledku
3
n4:pocetTvurcuVysledku
6
n4:rokUplatneniVysledku
n14:2005
n4:svazekPeriodika
17
n4:tvurceVysledku
Svoboda, Petr Novotný, Jiří Durchánková, Dana
n4:zamer
n9:AV0Z5011922
s:issn
0898-6568
s:numberOfPages
8
n11:organizacniJednotka
11310