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Statements

Subject Item
n2:RIV%2F00216208%3A11160%2F14%3A10282274%21RIV15-MSM-11160___
rdf:type
skos:Concept n13:Vysledek
rdfs:seeAlso
http://www.sciencedirect.com/science/article/pii/S022352341300812X
dcterms:description
A series of heterocyclic derivatives analogous to (-)vasicinone, in which the vasicinone C-ring was replaced with alkyl chain terminated by tertiary amine was prepared. N3, C4-O, C4-S or C4-N were used as the sites of attachment. The 4-[3-(1-piperidyl)propylsulfanyl]derivatives displayed bronchodilatory effect at low micromolar concentrations on isolated rat trachea, and low toxicity both on Balb/c 3T3 mouse fibroblast cells and in mice. A series of heterocyclic derivatives analogous to (-)vasicinone, in which the vasicinone C-ring was replaced with alkyl chain terminated by tertiary amine was prepared. N3, C4-O, C4-S or C4-N were used as the sites of attachment. The 4-[3-(1-piperidyl)propylsulfanyl]derivatives displayed bronchodilatory effect at low micromolar concentrations on isolated rat trachea, and low toxicity both on Balb/c 3T3 mouse fibroblast cells and in mice.
dcterms:title
Novel bronchodilatory quinazolines and quinoxalines: Synthesis and biological evaluation Novel bronchodilatory quinazolines and quinoxalines: Synthesis and biological evaluation
skos:prefLabel
Novel bronchodilatory quinazolines and quinoxalines: Synthesis and biological evaluation Novel bronchodilatory quinazolines and quinoxalines: Synthesis and biological evaluation
skos:notation
RIV/00216208:11160/14:10282274!RIV15-MSM-11160___
n3:aktivita
n5:I n5:S n5:P
n3:aktivity
I, P(EE2.3.30.0061), P(GAP207/10/2048), S
n3:cisloPeriodika
March
n3:dodaniDat
n4:2015
n3:domaciTvurceVysledku
Ghavre, Mukund n10:3654036 n10:4728858 n10:6031013 n10:6556981 n10:8323062 n10:1756419
n3:druhVysledku
n12:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
33084
n3:idVysledku
RIV/00216208:11160/14:10282274
n3:jazykVysledku
n19:eng
n3:klicovaSlova
Toxicity; Bronchodilator; Synthesis; Quinazoline; Vasicinone
n3:klicoveSlovo
n6:Bronchodilator n6:Toxicity n6:Quinazoline n6:Vasicinone n6:Synthesis
n3:kodStatuVydavatele
FR - Francouzská republika
n3:kontrolniKodProRIV
[F1D0D15C47D7]
n3:nazevZdroje
European Journal of Medicinal Chemistry
n3:obor
n18:FR
n3:pocetDomacichTvurcuVysledku
7
n3:pocetTvurcuVysledku
9
n3:projekt
n17:GAP207%2F10%2F2048 n17:EE2.3.30.0061
n3:rokUplatneniVysledku
n4:2014
n3:svazekPeriodika
74
n3:tvurceVysledku
Vacek, Jan Kuneš, Jiří Mikušek, Jiří Vopršalová, Marie Pourová, Jana Pour, Milan Ghavre, Mukund Gathergood, Nicholas Špulák, Marcel
n3:wos
000333780800008
s:issn
0223-5234
s:numberOfPages
8
n16:doi
10.1016/j.ejmech.2013.12.024
n20:organizacniJednotka
11160