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Subject Item
n2:RIV%2F00216208%3A11160%2F14%3A10282051%21RIV15-MSM-11160___
rdf:type
n20:Vysledek skos:Concept
rdfs:seeAlso
http://www.sciencedirect.com/science/article/pii/B9780444632814000069
dcterms:description
In the introductory chapter, the critical review about the use of small molecules of natural origin deals with the consequences of pathophysiological processes of Alzheimer's disease (AD) as essential basis for rational intervention to moderation of this disease. Substantial attention is given to impact on beta-amyloid (A beta) production, undesirable destructive processes, which take place in central nervous system on the basis of A beta activity, and possibilities of their affection (use of alpha-secretase elicitors, BACE1 inhibitors, antioxidants and scavengers, inhibitors of A beta-induced neurotoxicity, and A beta oligomer aggregation). Inhibitors of A beta-induced inflammation of cells and agonists of PPARgamma transcription factors also play significant role in this issue. During the AD progression, it is necessary to pay attention to tau-protein metabolism which is pathologically associated with tangles (glutaminyl cyclase inhibitors), and to interactions of A beta with the receptors for final products of advanced glycation (inhibitors of RAGEs). Within the scope of cholinergic theory, the attention is paid on natural cognitive drugs (inhibitors of acetyl- and butyrylcholinesterase), substances improving brain metabolism (nootropics), and compounds affecting brain concentration of some neuromediators (inhibitors of prolyl endopeptidase). In the introductory chapter, the critical review about the use of small molecules of natural origin deals with the consequences of pathophysiological processes of Alzheimer's disease (AD) as essential basis for rational intervention to moderation of this disease. Substantial attention is given to impact on beta-amyloid (A beta) production, undesirable destructive processes, which take place in central nervous system on the basis of A beta activity, and possibilities of their affection (use of alpha-secretase elicitors, BACE1 inhibitors, antioxidants and scavengers, inhibitors of A beta-induced neurotoxicity, and A beta oligomer aggregation). Inhibitors of A beta-induced inflammation of cells and agonists of PPARgamma transcription factors also play significant role in this issue. During the AD progression, it is necessary to pay attention to tau-protein metabolism which is pathologically associated with tangles (glutaminyl cyclase inhibitors), and to interactions of A beta with the receptors for final products of advanced glycation (inhibitors of RAGEs). Within the scope of cholinergic theory, the attention is paid on natural cognitive drugs (inhibitors of acetyl- and butyrylcholinesterase), substances improving brain metabolism (nootropics), and compounds affecting brain concentration of some neuromediators (inhibitors of prolyl endopeptidase).
dcterms:title
Natural Compounds (Small Molecules) as Potential and Real Drugs of Alzheimer's Disease: A Critical Review Natural Compounds (Small Molecules) as Potential and Real Drugs of Alzheimer's Disease: A Critical Review
skos:prefLabel
Natural Compounds (Small Molecules) as Potential and Real Drugs of Alzheimer's Disease: A Critical Review Natural Compounds (Small Molecules) as Potential and Real Drugs of Alzheimer's Disease: A Critical Review
skos:notation
RIV/00216208:11160/14:10282051!RIV15-MSM-11160___
n3:aktivita
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n3:aktivity
I, P(EE2.3.20.0235)
n3:dodaniDat
n16:2015
n3:domaciTvurceVysledku
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n3:duvernostUdaju
n21:S
n3:entitaPredkladatele
n8:predkladatel
n3:idSjednocenehoVysledku
31713
n3:idVysledku
RIV/00216208:11160/14:10282051
n3:jazykVysledku
n14:eng
n3:klicovaSlova
Critical review; Prospects of use; Alzheimer's disease; Natural substances; Small molecules
n3:klicoveSlovo
n7:Prospects%20of%20use n7:Small%20molecules n7:Natural%20substances n7:Alzheimer%27s%20disease n7:Critical%20review
n3:kontrolniKodProRIV
[3DEDA49DE802]
n3:mistoVydani
Oxford/Amsterdam
n3:nazevEdiceCisloSvazku
vol. 42
n3:nazevZdroje
Studies in Natural Products Chemistry
n3:obor
n12:FR
n3:pocetDomacichTvurcuVysledku
6
n3:pocetStranKnihy
472
n3:pocetTvurcuVysledku
6
n3:projekt
n22:EE2.3.20.0235
n3:rokUplatneniVysledku
n16:2014
n3:tvurceVysledku
Opletal, Lubomír Cahlíková, Lucie Hošťálková, Anna Macáková, Kateřina Benešová, Nina Chlebek, Jakub
s:numberOfPages
42
n17:doi
10.1016/B978-0-444-63281-4.00006-9
n15:hasPublisher
Elsevier
n18:isbn
978-0-444-63281-4
n19:organizacniJednotka
11160