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Statements

Subject Item
n2:RIV%2F00216208%3A11160%2F14%3A10281952%21RIV15-MSM-11160___
rdf:type
n16:Vysledek skos:Concept
rdfs:seeAlso
http://informahealthcare.com/doi/full/10.3109/14756366.2012.753589
dcterms:description
Coumarins have attracted intense interest in recent years because of their diverse pharmacological properties. According to our continuing investigations of biological effects of several coumarins, the structure-antioxidant activity relationships (SARs) of six naturally occurring coumarins and their 16 synthesized analogues were established. For this purpose, the very reliable colorimetric assay (ferric reducing antioxidant power) modified to be used in 96-well microplates was used. This approach, which determines the reducing capacity of tested compounds directly, has previously been used for the determination of SARs of flavonoids, but has not been used for SAR determination of coumarins. It is known that the biological properties and consequently, therapeutic application of simple coumarins depends upon the pattern of substitution. It was established that 7,8-dihydroxy- and 6,7-dihydroxy-4-methylcoumarins have shown excellent ferric-reducing properties. Coumarins have attracted intense interest in recent years because of their diverse pharmacological properties. According to our continuing investigations of biological effects of several coumarins, the structure-antioxidant activity relationships (SARs) of six naturally occurring coumarins and their 16 synthesized analogues were established. For this purpose, the very reliable colorimetric assay (ferric reducing antioxidant power) modified to be used in 96-well microplates was used. This approach, which determines the reducing capacity of tested compounds directly, has previously been used for the determination of SARs of flavonoids, but has not been used for SAR determination of coumarins. It is known that the biological properties and consequently, therapeutic application of simple coumarins depends upon the pattern of substitution. It was established that 7,8-dihydroxy- and 6,7-dihydroxy-4-methylcoumarins have shown excellent ferric-reducing properties.
dcterms:title
Evaluation of the antioxidant activity of several naturally occurring coumarins and their synthesized analogues by %22ferric reducing antioxidant power%22 assay Evaluation of the antioxidant activity of several naturally occurring coumarins and their synthesized analogues by %22ferric reducing antioxidant power%22 assay
skos:prefLabel
Evaluation of the antioxidant activity of several naturally occurring coumarins and their synthesized analogues by %22ferric reducing antioxidant power%22 assay Evaluation of the antioxidant activity of several naturally occurring coumarins and their synthesized analogues by %22ferric reducing antioxidant power%22 assay
skos:notation
RIV/00216208:11160/14:10281952!RIV15-MSM-11160___
n3:aktivita
n12:V n12:I n12:S n12:P
n3:aktivity
I, P(EE2.3.20.0235), S, V
n3:cisloPeriodika
1
n3:dodaniDat
n9:2015
n3:domaciTvurceVysledku
n8:1600664 n8:2790246 n8:4657853 n8:2389991 n8:1510274 n8:4391799
n3:druhVysledku
n17:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n11:predkladatel
n3:idSjednocenehoVysledku
15462
n3:idVysledku
RIV/00216208:11160/14:10281952
n3:jazykVysledku
n4:eng
n3:klicovaSlova
structure-activity relationship; ferric reducing antioxidant power; coumarins; Antioxidant
n3:klicoveSlovo
n7:ferric%20reducing%20antioxidant%20power n7:structure-activity%20relationship n7:Antioxidant n7:coumarins
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[4E38A89F140B]
n3:nazevZdroje
Journal of Enzyme Inhibition and Medicinal Chemistry
n3:obor
n20:FR
n3:pocetDomacichTvurcuVysledku
6
n3:pocetTvurcuVysledku
8
n3:projekt
n19:EE2.3.20.0235
n3:rokUplatneniVysledku
n9:2014
n3:svazekPeriodika
29
n3:tvurceVysledku
Opletal, Lubomír Jun, Daniel Řeháková, Zuzana Kolečkář, Vít Kuča, Kamil Cahlíková, Lucie Macáková, Kateřina Jahodář, Luděk
n3:wos
000330850300009
s:issn
1475-6366
s:numberOfPages
6
n10:doi
10.3109/14756366.2012.753589
n13:organizacniJednotka
11160