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Statements

Subject Item
n2:RIV%2F00216208%3A11160%2F14%3A10281583%21RIV15-MSM-11160___
rdf:type
n13:Vysledek skos:Concept
rdfs:seeAlso
http://www.degruyter.com/view/j/acph.2014.64.issue-2/acph-2014-0018/acph-2014-0018.xml
dcterms:description
Catechins may influence both desirable and undesirable effects of many drugs. In this study, the in vitro effect of (+)-catechin, (-)-epicatechin, (-)-epigallocatechin, (-)-epicatechin gallate, and (-)-epigallocatechin gallate (EGCG) on the efficacy of anticancer drug doxorubicin (DOX) was studied in HCT-8 cancer cells. Rat hepatocytes were used to study the influence of EGCG on DOX hepatotoxicity. Cell proliferation and viability were studied by 3-[4,5-dimethylthiazol- 2-yl]-2,5-diphenyl tetrazolium bromide and neutral red uptake test assays. Formation of reactive oxygen species (ROS) was determined using the dichlorofluorescein assay. All of the studied catechins (1-25 mu mol L-1) had no effect on the proliferation of intestinal cancer cells and did not affect the antiproliferative effect of DOX (1-8 mu mol L-1) in these cells. Moreover, EGCG at 25 mu mol L-1 increased the viability of isolated hepatocytes and significantly protected these cells against DOX-induced toxicity and ROS production. Consumption of EGCG during DOX therapy seems to be safe and beneficial, since EGCG does not decrease DOX anticancer efficacy and could ameliorate DOX hepatotoxicity. Catechins may influence both desirable and undesirable effects of many drugs. In this study, the in vitro effect of (+)-catechin, (-)-epicatechin, (-)-epigallocatechin, (-)-epicatechin gallate, and (-)-epigallocatechin gallate (EGCG) on the efficacy of anticancer drug doxorubicin (DOX) was studied in HCT-8 cancer cells. Rat hepatocytes were used to study the influence of EGCG on DOX hepatotoxicity. Cell proliferation and viability were studied by 3-[4,5-dimethylthiazol- 2-yl]-2,5-diphenyl tetrazolium bromide and neutral red uptake test assays. Formation of reactive oxygen species (ROS) was determined using the dichlorofluorescein assay. All of the studied catechins (1-25 mu mol L-1) had no effect on the proliferation of intestinal cancer cells and did not affect the antiproliferative effect of DOX (1-8 mu mol L-1) in these cells. Moreover, EGCG at 25 mu mol L-1 increased the viability of isolated hepatocytes and significantly protected these cells against DOX-induced toxicity and ROS production. Consumption of EGCG during DOX therapy seems to be safe and beneficial, since EGCG does not decrease DOX anticancer efficacy and could ameliorate DOX hepatotoxicity.
dcterms:title
Effect of selected catechins on doxorubicin antiproliferative efficacy and hepatotoxicity in vitro Effect of selected catechins on doxorubicin antiproliferative efficacy and hepatotoxicity in vitro
skos:prefLabel
Effect of selected catechins on doxorubicin antiproliferative efficacy and hepatotoxicity in vitro Effect of selected catechins on doxorubicin antiproliferative efficacy and hepatotoxicity in vitro
skos:notation
RIV/00216208:11160/14:10281583!RIV15-MSM-11160___
n3:aktivita
n6:P n6:I
n3:aktivity
I, P(EE2.3.30.0022), P(GBP303/12/G163)
n3:cisloPeriodika
2
n3:dodaniDat
n14:2015
n3:domaciTvurceVysledku
n8:2270455 n8:9958185 n8:1405764 n8:8996563 n8:2144204 n8:1935240
n3:druhVysledku
n10:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n20:predkladatel
n3:idSjednocenehoVysledku
13485
n3:idVysledku
RIV/00216208:11160/14:10281583
n3:jazykVysledku
n19:eng
n3:klicovaSlova
doxorubicin; hepatocytes; HCT-8 cells; chemoprevention; epigallocatechin gallate
n3:klicoveSlovo
n4:hepatocytes n4:HCT-8%20cells n4:doxorubicin n4:chemoprevention n4:epigallocatechin%20gallate
n3:kodStatuVydavatele
CR - Kostarická republika
n3:kontrolniKodProRIV
[EC47CE4EE605]
n3:nazevZdroje
Acta Pharmaceutica
n3:obor
n15:FR
n3:pocetDomacichTvurcuVysledku
6
n3:pocetTvurcuVysledku
6
n3:projekt
n17:GBP303%2F12%2FG163 n17:EE2.3.30.0022
n3:rokUplatneniVysledku
n14:2014
n3:svazekPeriodika
64
n3:tvurceVysledku
Hanušová, Veronika Boušová, Iva Rudolfová, Petra Matoušková, Petra Skálová, Lenka Bártíková, Hana
n3:wos
000337705100005
s:issn
1330-0075
s:numberOfPages
11
n7:doi
10.2478/acph-2014-0018
n11:organizacniJednotka
11160