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Statements

Subject Item
n2:RIV%2F00216208%3A11160%2F14%3A10281579%21RIV15-MSM-11160___
rdf:type
skos:Concept n14:Vysledek
rdfs:seeAlso
http://www.pjps.pk/wp-content/uploads/pdfs/27/1/Paper-15.pdf
dcterms:description
The aim of this study was to evaluate in vitro anti-proliferative (tested on MCF-7, MDA-MB-231, and MCF-10A cell lines) and anti-inflammatory (evaluated as inhibition of prostaglandin E-2 synthesis catalyzed by cyclooxygenase-2) effect of various extracts from Vaccinium bracteatum leaves and fruits. The highest anti-proliferative effect possessed leaf dichloromethane extract with IC50 values ranging from 93 to 198 mu g/mL. In the case of cyclooxygenase-2 inhibition, n-hexane, dichloromethane, and ethanol fruit extracts showed the best activity with IC50 values = 2.0, 5.4, and 12.7 mu g/mL, respectively. These results indicate that V bracteatum leaves and fruits could be useful source of anti-cancer and anti-inflammatory compounds. The aim of this study was to evaluate in vitro anti-proliferative (tested on MCF-7, MDA-MB-231, and MCF-10A cell lines) and anti-inflammatory (evaluated as inhibition of prostaglandin E-2 synthesis catalyzed by cyclooxygenase-2) effect of various extracts from Vaccinium bracteatum leaves and fruits. The highest anti-proliferative effect possessed leaf dichloromethane extract with IC50 values ranging from 93 to 198 mu g/mL. In the case of cyclooxygenase-2 inhibition, n-hexane, dichloromethane, and ethanol fruit extracts showed the best activity with IC50 values = 2.0, 5.4, and 12.7 mu g/mL, respectively. These results indicate that V bracteatum leaves and fruits could be useful source of anti-cancer and anti-inflammatory compounds.
dcterms:title
In vitro anti-proliferative and anti-inflammatory activity of leaf and fruit extracts from Vaccinium bracteatum Thunb. In vitro anti-proliferative and anti-inflammatory activity of leaf and fruit extracts from Vaccinium bracteatum Thunb.
skos:prefLabel
In vitro anti-proliferative and anti-inflammatory activity of leaf and fruit extracts from Vaccinium bracteatum Thunb. In vitro anti-proliferative and anti-inflammatory activity of leaf and fruit extracts from Vaccinium bracteatum Thunb.
skos:notation
RIV/00216208:11160/14:10281579!RIV15-MSM-11160___
n3:aktivita
n11:S n11:P n11:I
n3:aktivity
I, P(GBP303/12/G163), P(ME08070), S
n3:cisloPeriodika
1
n3:dodaniDat
n10:2015
n3:domaciTvurceVysledku
n9:1405764 n9:2270455
n3:druhVysledku
n15:J
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
21069
n3:idVysledku
RIV/00216208:11160/14:10281579
n3:jazykVysledku
n6:eng
n3:klicovaSlova
xCELLigence system; Vaccinium bracteatum; cyclooxygenase; breast cancer; anti-inflammatory activity; anti-proliferative activity
n3:klicoveSlovo
n4:anti-proliferative%20activity n4:xCELLigence%20system n4:cyclooxygenase n4:anti-inflammatory%20activity n4:breast%20cancer n4:Vaccinium%20bracteatum
n3:kodStatuVydavatele
PK - Pákistánská islámská republika
n3:kontrolniKodProRIV
[EF0001807B1A]
n3:nazevZdroje
Pakistan Journal of Pharmaceutical Sciences
n3:obor
n12:FR
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
7
n3:projekt
n13:ME08070 n13:GBP303%2F12%2FG163
n3:rokUplatneniVysledku
n10:2014
n3:svazekPeriodika
27
n3:tvurceVysledku
Lou, Ji-Dong Landa, Přemysl Boušová, Iva Skálová, Lenka Kutil, Zsofia Langhansová, Lenka Vaněk, Tomáš
n3:wos
000346327000015
s:issn
1011-601X
s:numberOfPages
4
n17:organizacniJednotka
11160