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Statements

Subject Item
n2:RIV%2F00216208%3A11160%2F14%3A10281506%21RIV15-MSM-11160___
rdf:type
skos:Concept n18:Vysledek
rdfs:seeAlso
http://biomed.papers.upol.cz/pdfs/bio/2014/03/03.pdf
dcterms:description
Background. Normal adults require twenty L-amino acids (AA) for protein synthesis. Functional AA regulate key metabolic pathways that are necessary for maintenance, growth, reproduction and immunity. Dietary supplementation with one or a mixture of these AA may be beneficial for ameliorating health problems at various stages of the life cycle and for optimizing of the efficiency of metabolic transformations. During disease, other amino acids also become essential. The principal goal of protein/amino acid administration in various pathological conditions in intensive care unit (ICU) patients is to provide the precursors of protein synthesis in tissues with high turnover and to protect skeletal muscle mass and function. Amino acid requirements in parenteral nutrition (PN) are higher when the patient is stressed/ traumatized/infected than in the unstressed state. In severely ill ICU patients a higher provision of protein and amino acids has been associated with a lower mortality. Methods and Results. An overview of the effects and dosage of amino acids in nutritional support of various pathological conditions in ICU patients is presented. Conclusion. It was demonstrated that 2.0-2.5 g protein substrate/kg normal body weight/day is safe and could be optimal for the most critically ill adults to decrease the risk of morbidity and mortality in some pathological conditions. Background. Normal adults require twenty L-amino acids (AA) for protein synthesis. Functional AA regulate key metabolic pathways that are necessary for maintenance, growth, reproduction and immunity. Dietary supplementation with one or a mixture of these AA may be beneficial for ameliorating health problems at various stages of the life cycle and for optimizing of the efficiency of metabolic transformations. During disease, other amino acids also become essential. The principal goal of protein/amino acid administration in various pathological conditions in intensive care unit (ICU) patients is to provide the precursors of protein synthesis in tissues with high turnover and to protect skeletal muscle mass and function. Amino acid requirements in parenteral nutrition (PN) are higher when the patient is stressed/ traumatized/infected than in the unstressed state. In severely ill ICU patients a higher provision of protein and amino acids has been associated with a lower mortality. Methods and Results. An overview of the effects and dosage of amino acids in nutritional support of various pathological conditions in ICU patients is presented. Conclusion. It was demonstrated that 2.0-2.5 g protein substrate/kg normal body weight/day is safe and could be optimal for the most critically ill adults to decrease the risk of morbidity and mortality in some pathological conditions.
dcterms:title
The importance and dosage of amino acids in nutritional support of various pathological conditions in ICU patients The importance and dosage of amino acids in nutritional support of various pathological conditions in ICU patients
skos:prefLabel
The importance and dosage of amino acids in nutritional support of various pathological conditions in ICU patients The importance and dosage of amino acids in nutritional support of various pathological conditions in ICU patients
skos:notation
RIV/00216208:11160/14:10281506!RIV15-MSM-11160___
n4:aktivita
n16:S n16:I
n4:aktivity
I, S
n4:cisloPeriodika
3
n4:dodaniDat
n15:2015
n4:domaciTvurceVysledku
n5:3868648 n5:9344624
n4:druhVysledku
n12:J
n4:duvernostUdaju
n19:S
n4:entitaPredkladatele
n17:predkladatel
n4:idSjednocenehoVysledku
20898
n4:idVysledku
RIV/00216208:11160/14:10281506
n4:jazykVysledku
n10:eng
n4:klicovaSlova
ICU patients; nutritional support; amino acids
n4:klicoveSlovo
n11:ICU%20patients n11:nutritional%20support n11:amino%20acids
n4:kodStatuVydavatele
CZ - Česká republika
n4:kontrolniKodProRIV
[524FD73BF94A]
n4:nazevZdroje
Biomedical Papers
n4:obor
n7:ED
n4:pocetDomacichTvurcuVysledku
2
n4:pocetTvurcuVysledku
3
n4:rokUplatneniVysledku
n15:2014
n4:svazekPeriodika
158
n4:tvurceVysledku
Pavlíčková Aimová, Petra Hronek, Miloslav Zadák, Zdeněk
n4:wos
000345398500003
s:issn
1213-8118
s:numberOfPages
10
n8:doi
10.5507/bp.2014.034
n14:organizacniJednotka
11160