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Statements

Subject Item
n2:RIV%2F00216208%3A11160%2F14%3A10272259%21RIV15-MSM-11160___
rdf:type
n20:Vysledek skos:Concept
rdfs:seeAlso
http://link.springer.com/chapter/10.1007/978-3-319-05458-2_62
dcterms:description
Novel imaging diagnostic method - wireless capsule enteroscopy was used in experimental gastroenterology studies in pigs. We monitored the disintegration of two types of drug forms in gastrointestinal tract for next optimalisation of pharmaceutical technology process. In parallel, the plasma time profiles of the active component were detected. In second study, scanning of intestinal mucous lesions was done as diagnostic tool. The disintegration of tablets was perceptible in the duodenal-jejunal segment (until the 90th min) and culminated in the proximal jejunum (at the 3rd hour). The peak of maximal concentration was reached between the 3rd and 6th hour. The most common lesions induced by non-steroidal anti-inflammatory drugs were red spots and erosions. Sensitivity and specificity of capsule endoscopy were more than 80% and 95%, respectively. Wireless capsule endoscopy is a highly accurate non-invasive method for evaluation of experimental NSAID-induced enteropathy and evaluation of tablet disintegration proces in the intestine. Novel imaging diagnostic method - wireless capsule enteroscopy was used in experimental gastroenterology studies in pigs. We monitored the disintegration of two types of drug forms in gastrointestinal tract for next optimalisation of pharmaceutical technology process. In parallel, the plasma time profiles of the active component were detected. In second study, scanning of intestinal mucous lesions was done as diagnostic tool. The disintegration of tablets was perceptible in the duodenal-jejunal segment (until the 90th min) and culminated in the proximal jejunum (at the 3rd hour). The peak of maximal concentration was reached between the 3rd and 6th hour. The most common lesions induced by non-steroidal anti-inflammatory drugs were red spots and erosions. Sensitivity and specificity of capsule endoscopy were more than 80% and 95%, respectively. Wireless capsule endoscopy is a highly accurate non-invasive method for evaluation of experimental NSAID-induced enteropathy and evaluation of tablet disintegration proces in the intestine.
dcterms:title
Imaging and Evaluating Method as Part of Endoscopical Diagnostic Approaches Imaging and Evaluating Method as Part of Endoscopical Diagnostic Approaches
skos:prefLabel
Imaging and Evaluating Method as Part of Endoscopical Diagnostic Approaches Imaging and Evaluating Method as Part of Endoscopical Diagnostic Approaches
skos:notation
RIV/00216208:11160/14:10272259!RIV15-MSM-11160___
n3:aktivita
n12:S n12:I
n3:aktivity
I, S
n3:dodaniDat
n18:2015
n3:domaciTvurceVysledku
n13:7291787
n3:druhVysledku
n17:D
n3:duvernostUdaju
n6:S
n3:entitaPredkladatele
n8:predkladatel
n3:idSjednocenehoVysledku
20486
n3:idVysledku
RIV/00216208:11160/14:10272259
n3:jazykVysledku
n14:eng
n3:klicovaSlova
drug forms; imaging method; enteropathy; Wireless capsule endoscopy
n3:klicoveSlovo
n4:imaging%20method n4:Wireless%20capsule%20endoscopy n4:drug%20forms n4:enteropathy
n3:kontrolniKodProRIV
[0B22EFCEE329]
n3:mistoKonaniAkce
Bangkok
n3:mistoVydani
Cham
n3:nazevZdroje
Inteligent Information and Database Systems: 6th Asian Conference, ACIIDS 2014, Bangkok, Thailand, April 7-9, 2014, Proceedings, Part II
n3:obor
n22:IN
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
8
n3:rokUplatneniVysledku
n18:2014
n3:tvurceVysledku
Bureš, Jan Krejcar, Ondřej Kuča, Kamil Květina, Jaroslav Nobilis, Milan Tachecí, Ilja Kuneš, Martin Kopáčová, Marcela
n3:typAkce
n10:WRD
n3:zahajeniAkce
2014-04-07+02:00
s:issn
0302-9743
s:numberOfPages
10
n7:doi
10.1007/978-3-319-05458-2_62
n5:hasPublisher
Spriger
n21:isbn
978-3-319-05458-2
n16:organizacniJednotka
11160