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Statements

Subject Item
n2:RIV%2F00216208%3A11160%2F13%3A10159264%21RIV14-MSM-11160___
rdf:type
skos:Concept n5:Vysledek
rdfs:seeAlso
http://journals.lww.com/anti-cancerdrugs/Abstract/2013/10000/Antiproliferative_effect_of_benzimidazole.5.aspx
dcterms:description
This study aimed to test the antiproliferative effect of three benzimidazole anthelmintics in intestinal cancer cells and to investigate whether these drugs, which inhibit tubulin polymerization, can potentiate the efficacy of the microtubule-stabilizing drug paclitaxel (PTX). Four intestinal cancer cell lines, SW480, SW620, HCT8, and Caco2, with different origins and growth characteristics were used. The antiproliferative effect of albendazole (ABZ), ricobendazole (RBZ), flubendazole (FLU), and their combinations with PTX was tested using three different end-point viability assays, cell cycle distribution analysis, and the x-CELLigence System for real-time cell analysis. ABZ and FLU inhibited cell proliferation significantly in a concentration-dependent and time-dependent manner through cell arrest in the G2/M phase. RBZ was not effective at any concentration tested. The cell lines differed in sensitivity to FLU and ABZ, with HCT8 being the most sensitive, showing IC50 values for ABZ and FLU that reached 0.3 and 0.9 micromol/l, respectively. Combinations of PTX+ABZ and PTX+FLU decreased cell viability more effectively when compared with treatment with individual drugs alone. The anthelmintic benzimidazole drugs ABZ and FLU show a significant cytostatic effect and potentiate the efficacy of PTX in intestinal cancer cells. This study aimed to test the antiproliferative effect of three benzimidazole anthelmintics in intestinal cancer cells and to investigate whether these drugs, which inhibit tubulin polymerization, can potentiate the efficacy of the microtubule-stabilizing drug paclitaxel (PTX). Four intestinal cancer cell lines, SW480, SW620, HCT8, and Caco2, with different origins and growth characteristics were used. The antiproliferative effect of albendazole (ABZ), ricobendazole (RBZ), flubendazole (FLU), and their combinations with PTX was tested using three different end-point viability assays, cell cycle distribution analysis, and the x-CELLigence System for real-time cell analysis. ABZ and FLU inhibited cell proliferation significantly in a concentration-dependent and time-dependent manner through cell arrest in the G2/M phase. RBZ was not effective at any concentration tested. The cell lines differed in sensitivity to FLU and ABZ, with HCT8 being the most sensitive, showing IC50 values for ABZ and FLU that reached 0.3 and 0.9 micromol/l, respectively. Combinations of PTX+ABZ and PTX+FLU decreased cell viability more effectively when compared with treatment with individual drugs alone. The anthelmintic benzimidazole drugs ABZ and FLU show a significant cytostatic effect and potentiate the efficacy of PTX in intestinal cancer cells.
dcterms:title
Antiproliferative effect of benzimidazole anthelmintics albendazole, ricobendazole, and flubendazole in intestinal cancer cell lines Antiproliferative effect of benzimidazole anthelmintics albendazole, ricobendazole, and flubendazole in intestinal cancer cell lines
skos:prefLabel
Antiproliferative effect of benzimidazole anthelmintics albendazole, ricobendazole, and flubendazole in intestinal cancer cell lines Antiproliferative effect of benzimidazole anthelmintics albendazole, ricobendazole, and flubendazole in intestinal cancer cell lines
skos:notation
RIV/00216208:11160/13:10159264!RIV14-MSM-11160___
n5:predkladatel
n6:orjk%3A11160
n3:aktivita
n15:S n15:I
n3:aktivity
I, S
n3:cisloPeriodika
9
n3:dodaniDat
n4:2014
n3:domaciTvurceVysledku
n7:8996563 n7:7268246 n7:3452026 n7:9948732 n7:2270455
n3:druhVysledku
n13:J
n3:duvernostUdaju
n11:S
n3:entitaPredkladatele
n14:predkladatel
n3:idSjednocenehoVysledku
61465
n3:idVysledku
RIV/00216208:11160/13:10159264
n3:jazykVysledku
n19:eng
n3:klicovaSlova
paclitaxel; microtubules; intestinal cancer cells; flubendazole; albendazole
n3:klicoveSlovo
n16:paclitaxel n16:flubendazole n16:intestinal%20cancer%20cells n16:albendazole n16:microtubules
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[AB949DDC7116]
n3:nazevZdroje
Anti-Cancer Drugs
n3:obor
n17:EB
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
6
n3:rokUplatneniVysledku
n4:2013
n3:svazekPeriodika
24
n3:tvurceVysledku
Knoppová, Kateřina Králová, Věra Skálová, Lenka Hanušová, Veronika Čáňová, Kristýna Staňková, Petra
n3:wos
000323885000005
s:issn
0959-4973
s:numberOfPages
9
n12:doi
10.1097/CAD.0b013e3283648c69
n20:organizacniJednotka
11160