This HTML5 document contains 55 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
dctermshttp://purl.org/dc/terms/
n18http://localhost/temp/predkladatel/
n20http://linked.opendata.cz/resource/domain/vavai/projekt/
n17http://linked.opendata.cz/resource/domain/vavai/riv/tvurce/
n12http://linked.opendata.cz/resource/domain/vavai/subjekt/
n10http://linked.opendata.cz/ontology/domain/vavai/
n6http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00216208%3A11160%2F13%3A10146053%21RIV14-MSM-11160___/
shttp://schema.org/
skoshttp://www.w3.org/2004/02/skos/core#
rdfshttp://www.w3.org/2000/01/rdf-schema#
n3http://linked.opendata.cz/ontology/domain/vavai/riv/
n15http://bibframe.org/vocab/
n2http://linked.opendata.cz/resource/domain/vavai/vysledek/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n5http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/
n9http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju/
xsdhhttp://www.w3.org/2001/XMLSchema#
n21http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku/
n13http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita/
n16http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku/
n11http://linked.opendata.cz/ontology/domain/vavai/riv/obor/
n7http://reference.data.gov.uk/id/gregorian-year/

Statements

Subject Item
n2:RIV%2F00216208%3A11160%2F13%3A10146053%21RIV14-MSM-11160___
rdf:type
n10:Vysledek skos:Concept
rdfs:seeAlso
http://www.future-science.com/doi/full/10.4155/bio.13.194
dcterms:description
Pteridines are a group of endogenous heterocyclic compounds whose concentrations in biological fluids may be increased in some disorders, such as infections, autoimmune disorders and cancer. In particular, pteridine concentrations in urine may represent promising noninvasive markers. However, their specificity requires further investigation. Pteridines can occur in three oxidation states with different stability. In order to enable the analysis of the unstable di- and tetra-hydroforms either an oxidation (mainly with iodine) or stabilization by reducing agents is applied. Due to the high polarity of pteridines, many analytical procedures employed ion-pair, ion-exchange or hydrophilic interaction liquid chromatography using mostly fluorescence detection. In the last decade, MS was found to be applicable. The objective of this Review is to show possibilities and different approaches in pteridine analysis in biological samples. Pteridines are a group of endogenous heterocyclic compounds whose concentrations in biological fluids may be increased in some disorders, such as infections, autoimmune disorders and cancer. In particular, pteridine concentrations in urine may represent promising noninvasive markers. However, their specificity requires further investigation. Pteridines can occur in three oxidation states with different stability. In order to enable the analysis of the unstable di- and tetra-hydroforms either an oxidation (mainly with iodine) or stabilization by reducing agents is applied. Due to the high polarity of pteridines, many analytical procedures employed ion-pair, ion-exchange or hydrophilic interaction liquid chromatography using mostly fluorescence detection. In the last decade, MS was found to be applicable. The objective of this Review is to show possibilities and different approaches in pteridine analysis in biological samples.
dcterms:title
Determination of pteridines in biological samples with an emphasis on their stability Determination of pteridines in biological samples with an emphasis on their stability
skos:prefLabel
Determination of pteridines in biological samples with an emphasis on their stability Determination of pteridines in biological samples with an emphasis on their stability
skos:notation
RIV/00216208:11160/13:10146053!RIV14-MSM-11160___
n10:predkladatel
n12:orjk%3A11160
n3:aktivita
n13:I n13:S n13:P
n3:aktivity
I, P(EE2.3.20.0235), S
n3:cisloPeriodika
18
n3:dodaniDat
n7:2014
n3:domaciTvurceVysledku
n17:7555350 n17:8491836 n17:4906268
n3:druhVysledku
n16:J
n3:duvernostUdaju
n9:S
n3:entitaPredkladatele
n6:predkladatel
n3:idSjednocenehoVysledku
68918
n3:idVysledku
RIV/00216208:11160/13:10146053
n3:jazykVysledku
n21:eng
n3:klicovaSlova
dihydropteridine reductase; marker pteridines; fluorescence detection; serum neopterin; human urine; fluorometric detection; L-ascorbic acid; GTP cyclohydrolase I; solid phase extraction; high performance liquid chromatography
n3:klicoveSlovo
n5:GTP%20cyclohydrolase%20I n5:serum%20neopterin n5:fluorometric%20detection n5:solid%20phase%20extraction n5:dihydropteridine%20reductase n5:high%20performance%20liquid%20chromatography n5:human%20urine n5:fluorescence%20detection n5:marker%20pteridines n5:L-ascorbic%20acid
n3:kodStatuVydavatele
PT - Portugalská republika
n3:kontrolniKodProRIV
[15BC4CB61B0D]
n3:nazevZdroje
Bioanalysis
n3:obor
n11:CB
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
4
n3:projekt
n20:EE2.3.20.0235
n3:rokUplatneniVysledku
n7:2013
n3:svazekPeriodika
5
n3:tvurceVysledku
Nováková, Lucie Solich, Petr Tomšík, Pavel Tomšíková, Helena
n3:wos
000325772200017
s:issn
1757-6180
s:numberOfPages
20
n15:doi
10.4155/bio.13.194
n18:organizacniJednotka
11160