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Statements

Subject Item
n2:RIV%2F00216208%3A11160%2F13%3A10145863%21RIV14-MSM-11160___
rdf:type
n12:Vysledek skos:Concept
dcterms:description
Eleven alkaloids were isolated from fresh bulbs of Chlidanthus fragrans. The chemical structures were elucidated by MS, and 1D and 2D NMR spectroscopic experiments. All compounds were evaluated for their erythrocytic acetylcholinesterase and serum butyrylcholinesterase inhibition activity using Ellman's method. In the prolyl oligopeptidase assay, Z-Gly-Pro-P-nitroaniline was used as substrate. In biological assays, only the crinine type Amaryllidaceae alkaloid undulatine showed promising acetylcholinesterase and prolyl oligopeptidase inhibition activity. Other isolated compounds were considered inactive. Eleven alkaloids were isolated from fresh bulbs of Chlidanthus fragrans. The chemical structures were elucidated by MS, and 1D and 2D NMR spectroscopic experiments. All compounds were evaluated for their erythrocytic acetylcholinesterase and serum butyrylcholinesterase inhibition activity using Ellman's method. In the prolyl oligopeptidase assay, Z-Gly-Pro-P-nitroaniline was used as substrate. In biological assays, only the crinine type Amaryllidaceae alkaloid undulatine showed promising acetylcholinesterase and prolyl oligopeptidase inhibition activity. Other isolated compounds were considered inactive.
dcterms:title
Alkaloids from Chlidanthus fragrans and their acetylcholinesterase, butyrylcholinesterase and prolyl oligopeptidase activities Alkaloids from Chlidanthus fragrans and their acetylcholinesterase, butyrylcholinesterase and prolyl oligopeptidase activities
skos:prefLabel
Alkaloids from Chlidanthus fragrans and their acetylcholinesterase, butyrylcholinesterase and prolyl oligopeptidase activities Alkaloids from Chlidanthus fragrans and their acetylcholinesterase, butyrylcholinesterase and prolyl oligopeptidase activities
skos:notation
RIV/00216208:11160/13:10145863!RIV14-MSM-11160___
n12:predkladatel
n15:orjk%3A11160
n3:aktivita
n5:S n5:P n5:I
n3:aktivity
I, P(EE2.3.20.0235), P(GAP303/11/1907), S
n3:cisloPeriodika
11
n3:dodaniDat
n16:2014
n3:domaciTvurceVysledku
n7:8323062 n7:5963702 n7:1600664 n7:7969619 n7:1206354 n7:1510274 n7:2790246 n7:9618848
n3:druhVysledku
n19:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
60107
n3:idVysledku
RIV/00216208:11160/13:10145863
n3:jazykVysledku
n10:eng
n3:klicovaSlova
prolyl oligopeptidase; butyrylcholinesterase; acetylcholinesterase; deoxypretazettine; Amaryllidaceae; Chlidanthus fragrans
n3:klicoveSlovo
n9:acetylcholinesterase n9:Amaryllidaceae n9:Chlidanthus%20fragrans n9:deoxypretazettine n9:prolyl%20oligopeptidase n9:butyrylcholinesterase
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[BA14D3B71354]
n3:nazevZdroje
Natural product communications
n3:obor
n4:FR
n3:pocetDomacichTvurcuVysledku
8
n3:pocetTvurcuVysledku
11
n3:projekt
n8:EE2.3.20.0235 n8:GAP303%2F11%2F1907
n3:rokUplatneniVysledku
n16:2013
n3:svazekPeriodika
8
n3:tvurceVysledku
Hrabinová, Martina Opletal, Lubomír Jun, Daniel Macáková, Kateřina Chlebek, Jakub Kuča, Kamil Cahlíková, Lucie Kuneš, Jiří Benešová, Nina Novák, Zdeněk Kulhánková, Andrea
n3:wos
000326859300010
s:issn
1934-578X
s:numberOfPages
4
n13:organizacniJednotka
11160