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Statements

Subject Item
n2:RIV%2F00216208%3A11160%2F13%3A10144248%21RIV14-MSM-11160___
rdf:type
skos:Concept n10:Vysledek
rdfs:seeAlso
http://www.ptfarm.pl/pub/File/Acta_Poloniae/2013/1/129-135.pdf
dcterms:description
The paper compared two spray-dried lactoses Flowlac (R) 100 and SuperTab (R) 14SD from the standpoint of tensile strength and disintegration time of tablets, the effect of an addition of the lubricant magnesium stearate and silicified microcrystalline cellulose on these properties, and also from the standpoint of the energy profile of compression. The comparison of the values was performed at the compression force of 15 IN. The strength of tablets was higher in the case of SuperTab 14SD, an increase in the concentration of magnesium stearate did not decrease tablet strength. Prosolv SMCC 90 increased the strength of tablets and made it equal for both lactoses, but it also increased the sensitivity to the added lubricant. The disintegration time of tablets was shorter in the case of SuperTab 14SD, an increased concentration of magnesium stearate prolonged it, and an addition of Prosolv SMCC 90 shortened it and made it equal for both lactoses. From the energy standpoint, the maximal energy was higher in the case of SuperTab 14SD, an addition of Prosolv SMCC 90 increased it and again made it equal for both lactoses. The differences in the values of the maximal energy were primarily due to the values of the energy for friction and the energy accumulated by the tablet after compression, and there was no marked difference in the values of the energy of decompression. SuperTab 14SD showed a higher plasticity than Flowlac 100. The paper compared two spray-dried lactoses Flowlac (R) 100 and SuperTab (R) 14SD from the standpoint of tensile strength and disintegration time of tablets, the effect of an addition of the lubricant magnesium stearate and silicified microcrystalline cellulose on these properties, and also from the standpoint of the energy profile of compression. The comparison of the values was performed at the compression force of 15 IN. The strength of tablets was higher in the case of SuperTab 14SD, an increase in the concentration of magnesium stearate did not decrease tablet strength. Prosolv SMCC 90 increased the strength of tablets and made it equal for both lactoses, but it also increased the sensitivity to the added lubricant. The disintegration time of tablets was shorter in the case of SuperTab 14SD, an increased concentration of magnesium stearate prolonged it, and an addition of Prosolv SMCC 90 shortened it and made it equal for both lactoses. From the energy standpoint, the maximal energy was higher in the case of SuperTab 14SD, an addition of Prosolv SMCC 90 increased it and again made it equal for both lactoses. The differences in the values of the maximal energy were primarily due to the values of the energy for friction and the energy accumulated by the tablet after compression, and there was no marked difference in the values of the energy of decompression. SuperTab 14SD showed a higher plasticity than Flowlac 100.
dcterms:title
Comparison of properties of tablets and energy profile of compaction of two spray-dried lactoses Comparison of properties of tablets and energy profile of compaction of two spray-dried lactoses
skos:prefLabel
Comparison of properties of tablets and energy profile of compaction of two spray-dried lactoses Comparison of properties of tablets and energy profile of compaction of two spray-dried lactoses
skos:notation
RIV/00216208:11160/13:10144248!RIV14-MSM-11160___
n10:predkladatel
n11:orjk%3A11160
n3:aktivita
n8:I
n3:aktivity
I
n3:cisloPeriodika
1
n3:dodaniDat
n14:2014
n3:domaciTvurceVysledku
n16:5477220 n16:7575203
n3:druhVysledku
n6:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n4:predkladatel
n3:idSjednocenehoVysledku
66284
n3:idVysledku
RIV/00216208:11160/13:10144248
n3:jazykVysledku
n19:eng
n3:klicovaSlova
force - displacement profile; disintegration time of tablets; tensile strength of tablets; silicified microcrystalline cellulose; spray-dried lactose
n3:klicoveSlovo
n7:tensile%20strength%20of%20tablets n7:spray-dried%20lactose n7:silicified%20microcrystalline%20cellulose n7:disintegration%20time%20of%20tablets n7:force
n3:kodStatuVydavatele
PL - Polská republika
n3:kontrolniKodProRIV
[4A09316A2785]
n3:nazevZdroje
Acta Poloniae Pharmaceutica
n3:obor
n18:FR
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
2
n3:rokUplatneniVysledku
n14:2013
n3:svazekPeriodika
70
n3:tvurceVysledku
Mužíková, Jitka Šináglová, Pavla
n3:wos
000316432000015
s:issn
0001-6837
s:numberOfPages
7
n17:organizacniJednotka
11160