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Statements

Subject Item
n2:RIV%2F00216208%3A11160%2F12%3A10129659%21RIV13-MSM-11160___
rdf:type
skos:Concept n18:Vysledek
rdfs:seeAlso
http://informahealthcare.com/doi/abs/10.3109/03602532.2012.713969
dcterms:description
Many studies reviewed herein demonstrated the potency of some flavonoids to modulate the activity and/or expression of glutathione S-transferases (GSTs). Because GSTs play a crucial role in the detoxification of xenobiotics, their inhibition or induction may significantly affect metabolism and biological effects of many drugs, industrials, and environmental contaminants. The effect of flavonoids on GSTs strongly depends on flavonoid structure, concentration, period of administration, as well as on GST isoform and origin. Moreover, the results obtained in vitro are often contrary to the vivo results. Based on these facts, the revelation of important flavonoid-drug or flavonoid-pollutant interaction has been complicated. However, it should be borne in mind that ingestion of certain flavonoids in combination with drugs or pollutants (e.g., acetaminophen, simvastatin, cyclophosphamide, cisplatine, polycyclic aromatic hydrocarbons, chlorpyrifos, acrylamide, and isocyanates), which are GST substrates, could have significant pharmacological and toxicological consequences. Although reasonable consumptions of a flavonoids-rich diet (that may lead to GST induction) are mostly beneficial, the uncontrolled intake of high concentrations of certain flavonoids (e.g., quercetin and catechins) in dietary supplements (that may cause GST inhibition) may threaten human health. Many studies reviewed herein demonstrated the potency of some flavonoids to modulate the activity and/or expression of glutathione S-transferases (GSTs). Because GSTs play a crucial role in the detoxification of xenobiotics, their inhibition or induction may significantly affect metabolism and biological effects of many drugs, industrials, and environmental contaminants. The effect of flavonoids on GSTs strongly depends on flavonoid structure, concentration, period of administration, as well as on GST isoform and origin. Moreover, the results obtained in vitro are often contrary to the vivo results. Based on these facts, the revelation of important flavonoid-drug or flavonoid-pollutant interaction has been complicated. However, it should be borne in mind that ingestion of certain flavonoids in combination with drugs or pollutants (e.g., acetaminophen, simvastatin, cyclophosphamide, cisplatine, polycyclic aromatic hydrocarbons, chlorpyrifos, acrylamide, and isocyanates), which are GST substrates, could have significant pharmacological and toxicological consequences. Although reasonable consumptions of a flavonoids-rich diet (that may lead to GST induction) are mostly beneficial, the uncontrolled intake of high concentrations of certain flavonoids (e.g., quercetin and catechins) in dietary supplements (that may cause GST inhibition) may threaten human health.
dcterms:title
Inhibition and induction of glutathione S-transferases by flavonoids: possible pharmacological and toxicological consequences Inhibition and induction of glutathione S-transferases by flavonoids: possible pharmacological and toxicological consequences
skos:prefLabel
Inhibition and induction of glutathione S-transferases by flavonoids: possible pharmacological and toxicological consequences Inhibition and induction of glutathione S-transferases by flavonoids: possible pharmacological and toxicological consequences
skos:notation
RIV/00216208:11160/12:10129659!RIV13-MSM-11160___
n18:predkladatel
n19:orjk%3A11160
n4:aktivita
n17:I n17:P
n4:aktivity
I, P(GBP303/12/G163)
n4:cisloPeriodika
4
n4:dodaniDat
n20:2013
n4:domaciTvurceVysledku
n9:2270455 n9:1405764
n4:druhVysledku
n13:J
n4:duvernostUdaju
n8:S
n4:entitaPredkladatele
n5:predkladatel
n4:idSjednocenehoVysledku
141850
n4:idVysledku
RIV/00216208:11160/12:10129659
n4:jazykVysledku
n21:eng
n4:klicovaSlova
detoxification; cytostatics; dietary supplement; drug-flavonoid interaction; GST
n4:klicoveSlovo
n11:GST n11:dietary%20supplement n11:cytostatics n11:drug-flavonoid%20interaction n11:detoxification
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[6D07D8907979]
n4:nazevZdroje
Drug Metabolism Reviews
n4:obor
n10:CE
n4:pocetDomacichTvurcuVysledku
2
n4:pocetTvurcuVysledku
2
n4:projekt
n15:GBP303%2F12%2FG163
n4:rokUplatneniVysledku
n20:2012
n4:svazekPeriodika
44
n4:tvurceVysledku
Skálová, Lenka Boušová, Iva
n4:wos
000312218600001
s:issn
0360-2532
s:numberOfPages
20
n12:doi
10.3109/03602532.2012.713969
n7:organizacniJednotka
11160