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Statements

Subject Item
n2:RIV%2F00216208%3A11160%2F12%3A10125130%21RIV13-MSM-11160___
rdf:type
n12:Vysledek skos:Concept
rdfs:seeAlso
http://www.prolekare.cz/ceska-slovenska-farmacie-clanek/vysoce-ucinne-potencialni-antimykobakterialni-latky-proti-em-mycobacterium-avium-em-38561
dcterms:description
Derivatives of 3-phenyl-2H-1,3-benzoxazme-2,4(3H)- -dione are active against Mycobacterium avium when substituted in position 7 with a methyl. One or two carbonyl groups have to be replaced with a thioxo group. High active derivatives are the compounds without substitution on the phenyl, or those substituted on the phenyl in position 3 or 4 with chlorine, bromine or a methyl. The substitution in position 3 and 4 with two atoms of chlorine lowers the activity. The compounds are active against INH resistant strains. We synthesized other 44 derivatives with a similar structure of the compounds as in the paper but substituted in position 7 with other substituents (chlorine, bromine methoxy). The activity against M. avium was poor. It can be concluded that a new group of compounds with an excellent activity against M. avium has been found. Derivatives of 3-phenyl-2H-1,3-benzoxazme-2,4(3H)- -dione are active against Mycobacterium avium when substituted in position 7 with a methyl. One or two carbonyl groups have to be replaced with a thioxo group. High active derivatives are the compounds without substitution on the phenyl, or those substituted on the phenyl in position 3 or 4 with chlorine, bromine or a methyl. The substitution in position 3 and 4 with two atoms of chlorine lowers the activity. The compounds are active against INH resistant strains. We synthesized other 44 derivatives with a similar structure of the compounds as in the paper but substituted in position 7 with other substituents (chlorine, bromine methoxy). The activity against M. avium was poor. It can be concluded that a new group of compounds with an excellent activity against M. avium has been found.
dcterms:title
High active potential antimycobacterial agents against Mycobacterium avium High active potential antimycobacterial agents against Mycobacterium avium
skos:prefLabel
High active potential antimycobacterial agents against Mycobacterium avium High active potential antimycobacterial agents against Mycobacterium avium
skos:notation
RIV/00216208:11160/12:10125130!RIV13-MSM-11160___
n12:predkladatel
n17:orjk%3A11160
n3:aktivita
n11:I
n3:aktivity
I
n3:cisloPeriodika
3
n3:dodaniDat
n7:2013
n3:domaciTvurceVysledku
n4:8148295 n4:8323062
n3:druhVysledku
n13:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n6:predkladatel
n3:idSjednocenehoVysledku
138914
n3:idVysledku
RIV/00216208:11160/12:10125130
n3:jazykVysledku
n16:eng
n3:klicovaSlova
antimycobacterial activity; Mycobacterium avium; thioxo group; benzoxazine
n3:klicoveSlovo
n15:Mycobacterium%20avium n15:thioxo%20group n15:benzoxazine n15:antimycobacterial%20activity
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[29F32A4B5BF7]
n3:nazevZdroje
Česká a slovenská farmacie
n3:obor
n14:FR
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
3
n3:rokUplatneniVysledku
n7:2012
n3:svazekPeriodika
61
n3:tvurceVysledku
Kuneš, Jiří Waisser, Karel Stolaříková, Jiřina
s:issn
1210-7816
s:numberOfPages
3
n10:organizacniJednotka
11160