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Statements

Subject Item
n2:RIV%2F00216208%3A11160%2F12%3A10124209%21RIV13-MSM-11160___
rdf:type
skos:Concept n14:Vysledek
rdfs:seeAlso
http://ar.iiarjournals.org/content/32/3/815.full
dcterms:description
Somatostatin receptor targeting is a valuable method to treat somatostatin receptor-positive tumours. In peptide receptor radionuclide therapy, it is essential to determine the highest activity that can be safely administered to the patient. As Y-90 emits no gamma rays, absorbed doses for Y-90 are usually estimated using the same peptide labelled with In-111. The aim of the study was to determine if replacement of Y-90/88 by In-111 affects the biodistribution profile of five selected somatostatin analogues in preclinical experiments. Materials and Methods: Radiolabelled peptides were atministered in to male Wistar rats. Results: The peptides under studs, labelled either with In-111 or with Y-88/90 showed similar distribution profiles in all tissues excepting the kidney. The kidney radioactivity uptake was significantly lower for Y-88/90-labeled peptide in comparison with the one of In-111. Conclusion: We conclude that a radiation-absorbed dose after Y-90-labelled somatostatin analogues appears to be lower than that predicted by the In-111-labelled peptide. Somatostatin receptor targeting is a valuable method to treat somatostatin receptor-positive tumours. In peptide receptor radionuclide therapy, it is essential to determine the highest activity that can be safely administered to the patient. As Y-90 emits no gamma rays, absorbed doses for Y-90 are usually estimated using the same peptide labelled with In-111. The aim of the study was to determine if replacement of Y-90/88 by In-111 affects the biodistribution profile of five selected somatostatin analogues in preclinical experiments. Materials and Methods: Radiolabelled peptides were atministered in to male Wistar rats. Results: The peptides under studs, labelled either with In-111 or with Y-88/90 showed similar distribution profiles in all tissues excepting the kidney. The kidney radioactivity uptake was significantly lower for Y-88/90-labeled peptide in comparison with the one of In-111. Conclusion: We conclude that a radiation-absorbed dose after Y-90-labelled somatostatin analogues appears to be lower than that predicted by the In-111-labelled peptide.
dcterms:title
Different Radioactivity Uptake between Somatostatin Analogues Labelled with In-111 and Y-90/88 in Rat Kidney Different Radioactivity Uptake between Somatostatin Analogues Labelled with In-111 and Y-90/88 in Rat Kidney
skos:prefLabel
Different Radioactivity Uptake between Somatostatin Analogues Labelled with In-111 and Y-90/88 in Rat Kidney Different Radioactivity Uptake between Somatostatin Analogues Labelled with In-111 and Y-90/88 in Rat Kidney
skos:notation
RIV/00216208:11160/12:10124209!RIV13-MSM-11160___
n14:predkladatel
n16:orjk%3A11160
n3:aktivita
n11:I n11:P
n3:aktivity
I, P(GAP304/10/1738), P(OC08006)
n3:cisloPeriodika
3
n3:dodaniDat
n5:2013
n3:domaciTvurceVysledku
n8:9593756 n8:5940583
n3:druhVysledku
n15:J
n3:duvernostUdaju
n9:S
n3:entitaPredkladatele
n10:predkladatel
n3:idSjednocenehoVysledku
131248
n3:idVysledku
RIV/00216208:11160/12:10124209
n3:jazykVysledku
n18:eng
n3:klicovaSlova
kidney uptake; Y-90/88; In-111; somatostatin analogue
n3:klicoveSlovo
n4:In-111 n4:somatostatin%20analogue n4:kidney%20uptake n4:Y-90%2F88
n3:kodStatuVydavatele
GR - Řecká republika
n3:kontrolniKodProRIV
[9A43B4924D77]
n3:nazevZdroje
Anticancer Research
n3:obor
n20:FD
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
2
n3:projekt
n19:OC08006 n19:GAP304%2F10%2F1738
n3:rokUplatneniVysledku
n5:2012
n3:svazekPeriodika
32
n3:tvurceVysledku
Lázníčková, Alice Lázníček, Milan
n3:wos
000301619200017
s:issn
0250-7005
s:numberOfPages
8
n12:organizacniJednotka
11160