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Statements

Subject Item
n2:RIV%2F00216208%3A11160%2F11%3A10099482%21RIV12-MZ0-11160___
rdf:type
skos:Concept n14:Vysledek
rdfs:seeAlso
http://www.sciencedirect.com/science/article/pii/S0144861710008660
dcterms:description
Water-soluble chitosan conjugates were prepared by connection with isoniazid, pyrazinamide and ethionamide across the O-carboxymethyl and N-succinyl bridge followed by phosphorylation. Their structures were characterized by FTIR and (1)H NMR spectroscopy. Degree of drug substitution and molecular weight of prepared compounds have been investigated. Antimycobacterial activity was determined against Mycobacterium tuberculosis and three non-tuberculosis strains. Water-soluble chitosan conjugates were prepared by connection with isoniazid, pyrazinamide and ethionamide across the O-carboxymethyl and N-succinyl bridge followed by phosphorylation. Their structures were characterized by FTIR and (1)H NMR spectroscopy. Degree of drug substitution and molecular weight of prepared compounds have been investigated. Antimycobacterial activity was determined against Mycobacterium tuberculosis and three non-tuberculosis strains.
dcterms:title
Cytotoxicity decreasing effect and antimycobacterial activity of chitosan conjugated with antituberculotic drugs Cytotoxicity decreasing effect and antimycobacterial activity of chitosan conjugated with antituberculotic drugs
skos:prefLabel
Cytotoxicity decreasing effect and antimycobacterial activity of chitosan conjugated with antituberculotic drugs Cytotoxicity decreasing effect and antimycobacterial activity of chitosan conjugated with antituberculotic drugs
skos:notation
RIV/00216208:11160/11:10099482!RIV12-MZ0-11160___
n14:predkladatel
n22:orjk%3A11160
n3:aktivita
n16:S n16:P n16:Z
n3:aktivity
P(NS10367), S, Z(MSM0021620822)
n3:cisloPeriodika
4
n3:dodaniDat
n12:2012
n3:domaciTvurceVysledku
n11:8634351 n11:2624052 n11:2112884 n11:3161579
n3:druhVysledku
n13:J
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n5:predkladatel
n3:idSjednocenehoVysledku
192644
n3:idVysledku
RIV/00216208:11160/11:10099482
n3:jazykVysledku
n9:eng
n3:klicovaSlova
Cytotoxicity; In vitro antimycobacterial activity; Ethionamide; Pyrazinamide; Isoniazid; Chitosan
n3:klicoveSlovo
n4:Pyrazinamide n4:Cytotoxicity n4:Chitosan n4:In%20vitro%20antimycobacterial%20activity n4:Ethionamide n4:Isoniazid
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[BD4E36E49CBE]
n3:nazevZdroje
Carbohydrate Polymers
n3:obor
n7:FR
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
7
n3:projekt
n20:NS10367
n3:rokUplatneniVysledku
n12:2011
n3:svazekPeriodika
83
n3:tvurceVysledku
Bősze, Szilvia Trejtnar, František Vavříková, Eva Mandíková, Jana Horváti, Kata Vinšová, Jarmila Stolaříková, Jiřina
n3:wos
000286965400062
n3:zamer
n21:MSM0021620822
s:issn
0144-8617
s:numberOfPages
7
n15:doi
10.1016/j.carbpol.2010.10.053
n17:organizacniJednotka
11160