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Statements

Subject Item
n2:RIV%2F00216208%3A11160%2F10%3A00300602%21RIV11-MSM-11160___
rdf:type
skos:Concept n13:Vysledek
dcterms:description
It is widely believed that P-glycoprotein, together with other ATP efflux drug transporters, plays a crucial role in the host detoxication and protection against xenobiotic substances. On the other hand, the presence of these transporters in normal tissues may prevent pharmacotherapeutic agents from reaching their site of action, thus limiting their therapeutic potential. This review focuses on P-glycoprotein, its expression, localization, and function in nontumor tissues and the pharmacological consequences hereof. Special attention is paid to its role in pharmacokinetics of the small intestine, brain, kidney, liver and placenta. It is widely believed that P-glycoprotein, together with other ATP efflux drug transporters, plays a crucial role in the host detoxication and protection against xenobiotic substances. On the other hand, the presence of these transporters in normal tissues may prevent pharmacotherapeutic agents from reaching their site of action, thus limiting their therapeutic potential. This review focuses on P-glycoprotein, its expression, localization, and function in nontumor tissues and the pharmacological consequences hereof. Special attention is paid to its role in pharmacokinetics of the small intestine, brain, kidney, liver and placenta.
dcterms:title
Expression and function of P-glycoprotein in normal tissues: Effect on pharmacokinetics Expression and function of P-glycoprotein in normal tissues: Effect on pharmacokinetics
skos:prefLabel
Expression and function of P-glycoprotein in normal tissues: Effect on pharmacokinetics Expression and function of P-glycoprotein in normal tissues: Effect on pharmacokinetics
skos:notation
RIV/00216208:11160/10:00300602!RIV11-MSM-11160___
n3:aktivita
n7:V n7:I
n3:aktivity
I, V
n3:cisloPeriodika
596
n3:dodaniDat
n15:2011
n3:domaciTvurceVysledku
n9:2587211 n9:4835549 n9:8553475
n3:druhVysledku
n16:J
n3:duvernostUdaju
n12:S
n3:entitaPredkladatele
n8:predkladatel
n3:idSjednocenehoVysledku
258512
n3:idVysledku
RIV/00216208:11160/10:00300602
n3:jazykVysledku
n14:eng
n3:klicovaSlova
P-glycoprotein; expression; function; localization; normal tissues; pharmacokinetics; drug absorption; drug distribution; drug excretion
n3:klicoveSlovo
n4:expression n4:P-glycoprotein n4:pharmacokinetics n4:drug%20absorption n4:drug%20distribution n4:drug%20excretion n4:localization n4:function n4:normal%20tissues
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[42AAF486249F]
n3:nazevZdroje
Methods in Molecular Biology
n3:obor
n17:FR
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
4
n3:rokUplatneniVysledku
n15:2010
n3:svazekPeriodika
596
n3:tvurceVysledku
Pávek, Petr Čečková, Martina Mičuda, Stanislav Štaud, František
s:issn
1940-6029
s:numberOfPages
24
n11:organizacniJednotka
11160