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Statements

Subject Item
n2:RIV%2F00216208%3A11160%2F10%3A00300544%21RIV11-MSM-11160___
rdf:type
n18:Vysledek skos:Concept
dcterms:description
In our project we try to characterize the effect of phytic acid (IP6) as a potential adjuvant in treatment of colorectal carcinoma. There is some evidence that myo-inositol (Ins) can potentiate anticancer effects of IP6. Therefore we tested both IP6 and Ins individually and in combination on human cell lines HT-29, SW-480 and SW-620 derived from the colorectal carcinoma in different stages of malignancy. The effect of tested chemicals on the cells was measured using WST, BrdU, Brilliant Blue and caspase-3 activity. We tested IP6 and Ins at three concentrations: 0.2, 1 and 5 mM during 24, 48 and 72 hours. We found that all employed concentrations of IP6 or IP6/Ins decreased proliferation of all cell lines. Metabolic activity and protein content of treated cells differed in response to IP6 and IP6/Ins treatment. We found the maximum increase in caspase-3 activity in HT-29 (5mM) and in SW480 (0,2 mM) with clear indication of Ins enhancing the proapoptotic effect of IP6 in all cell lines. In our project we try to characterize the effect of phytic acid (IP6) as a potential adjuvant in treatment of colorectal carcinoma. There is some evidence that myo-inositol (Ins) can potentiate anticancer effects of IP6. Therefore we tested both IP6 and Ins individually and in combination on human cell lines HT-29, SW-480 and SW-620 derived from the colorectal carcinoma in different stages of malignancy. The effect of tested chemicals on the cells was measured using WST, BrdU, Brilliant Blue and caspase-3 activity. We tested IP6 and Ins at three concentrations: 0.2, 1 and 5 mM during 24, 48 and 72 hours. We found that all employed concentrations of IP6 or IP6/Ins decreased proliferation of all cell lines. Metabolic activity and protein content of treated cells differed in response to IP6 and IP6/Ins treatment. We found the maximum increase in caspase-3 activity in HT-29 (5mM) and in SW480 (0,2 mM) with clear indication of Ins enhancing the proapoptotic effect of IP6 in all cell lines.
dcterms:title
Effect of phytic acid and inositol on the proliferation and apoptosis of cells derived from colorectal carcinoma Effect of phytic acid and inositol on the proliferation and apoptosis of cells derived from colorectal carcinoma
skos:prefLabel
Effect of phytic acid and inositol on the proliferation and apoptosis of cells derived from colorectal carcinoma Effect of phytic acid and inositol on the proliferation and apoptosis of cells derived from colorectal carcinoma
skos:notation
RIV/00216208:11160/10:00300544!RIV11-MSM-11160___
n4:aktivita
n9:Z n9:S
n4:aktivity
S, Z(MSM0021620820)
n4:cisloPeriodika
3
n4:dodaniDat
n6:2011
n4:domaciTvurceVysledku
n13:6511341
n4:druhVysledku
n12:J
n4:duvernostUdaju
n11:S
n4:entitaPredkladatele
n8:predkladatel
n4:idSjednocenehoVysledku
256099
n4:idVysledku
RIV/00216208:11160/10:00300544
n4:jazykVysledku
n15:eng
n4:klicovaSlova
phytic acid; inositol; colorectal cancer; apoptosis; proliferation
n4:klicoveSlovo
n5:phytic%20acid n5:apoptosis n5:inositol n5:colorectal%20cancer n5:proliferation
n4:kodStatuVydavatele
GR - Řecká republika
n4:kontrolniKodProRIV
[8864252F5D46]
n4:nazevZdroje
Oncology Reports
n4:obor
n17:EB
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
4
n4:rokUplatneniVysledku
n6:2010
n4:svazekPeriodika
23
n4:tvurceVysledku
Schröterová, Ladislava Červinka, Miroslav Rudolf, Emil Hašková, Pavlína
n4:wos
000275226100026
n4:zamer
n16:MSM0021620820
s:issn
1021-335X
s:numberOfPages
7
n14:organizacniJednotka
11160