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Statements

Subject Item
n2:RIV%2F00216208%3A11150%2F14%3A10283857%21RIV15-MSM-11150___
rdf:type
skos:Concept n14:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1016/j.ajog.2014.03.069
dcterms:description
OBJECTIVE: The objective of the study was to determine the diagnostic indices and predictive values by bedside assessment of amniotic fluid interleukin-6 (IL-6) concentration in the identification of microbial invasion of the amniotic cavity (MIAC) and/or histological chorioamnionitis (HCA) in patients with preterm prelabor rupture of membranes. STUDY DESIGN: One hundred twenty-four women with singleton pregnancies were included in this study. The amniotic fluid was sampled by transabdominal amniocentesis at the time of admission. IL-6 concentrations were assessed with an immunoassay. RESULTS: The presence of MIAC, HCA, or the coexistence of both was associated with higher amniotic fluid concentrations of IL-6 in both a crude and adjusted analysis. The amniotic fluid concentration of IL-6 of 1000 pg/mL was determined to be the best cutoff value for the prediction of MIAC (sensitivity of 50%, specificity of 95%, positive predictive value of 82%, negative predictive value of 81%, and likelihood ratio of 8.4) or both MIAC and HCA (sensitivity of 60%, specificity of 94%, positive predictive value of 75%, negative predictive value of 88%, and likelihood ratio of 9.4). CONCLUSION: The bedside assessment of amniotic fluid IL-6 seems to be an easy, rapid, and inexpensive method for the prediction of MIAC or both MIAC and HCA in pregnancies complicated by preterm prelabor rupture of membranes. OBJECTIVE: The objective of the study was to determine the diagnostic indices and predictive values by bedside assessment of amniotic fluid interleukin-6 (IL-6) concentration in the identification of microbial invasion of the amniotic cavity (MIAC) and/or histological chorioamnionitis (HCA) in patients with preterm prelabor rupture of membranes. STUDY DESIGN: One hundred twenty-four women with singleton pregnancies were included in this study. The amniotic fluid was sampled by transabdominal amniocentesis at the time of admission. IL-6 concentrations were assessed with an immunoassay. RESULTS: The presence of MIAC, HCA, or the coexistence of both was associated with higher amniotic fluid concentrations of IL-6 in both a crude and adjusted analysis. The amniotic fluid concentration of IL-6 of 1000 pg/mL was determined to be the best cutoff value for the prediction of MIAC (sensitivity of 50%, specificity of 95%, positive predictive value of 82%, negative predictive value of 81%, and likelihood ratio of 8.4) or both MIAC and HCA (sensitivity of 60%, specificity of 94%, positive predictive value of 75%, negative predictive value of 88%, and likelihood ratio of 9.4). CONCLUSION: The bedside assessment of amniotic fluid IL-6 seems to be an easy, rapid, and inexpensive method for the prediction of MIAC or both MIAC and HCA in pregnancies complicated by preterm prelabor rupture of membranes.
dcterms:title
Bedside assessment of amniotic fluid interleukin-6 in preterm prelabor rupture of membranes Bedside assessment of amniotic fluid interleukin-6 in preterm prelabor rupture of membranes
skos:prefLabel
Bedside assessment of amniotic fluid interleukin-6 in preterm prelabor rupture of membranes Bedside assessment of amniotic fluid interleukin-6 in preterm prelabor rupture of membranes
skos:notation
RIV/00216208:11150/14:10283857!RIV15-MSM-11150___
n3:aktivita
n17:I
n3:aktivity
I
n3:cisloPeriodika
4
n3:dodaniDat
n5:2015
n3:domaciTvurceVysledku
n10:8855110 n10:4148878 n10:4203291 n10:1807676
n3:druhVysledku
n15:J
n3:duvernostUdaju
n13:S
n3:entitaPredkladatele
n19:predkladatel
n3:idSjednocenehoVysledku
4972
n3:idVysledku
RIV/00216208:11150/14:10283857
n3:jazykVysledku
n18:eng
n3:klicovaSlova
microbial invasion of the amniotic fluid; interleukin-6; histological chorioamnionitis; cytokine; amniotic fluid
n3:klicoveSlovo
n4:histological%20chorioamnionitis n4:microbial%20invasion%20of%20the%20amniotic%20fluid n4:cytokine n4:interleukin-6 n4:amniotic%20fluid
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[CE940204F3DF]
n3:nazevZdroje
American Journal of Obstetrics and Gynecology
n3:obor
n16:FK
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
7
n3:rokUplatneniVysledku
n5:2014
n3:svazekPeriodika
211
n3:tvurceVysledku
Plíšková, Lenka Jacobsson, Bo Kutová, Radka Košťál, Milan Hornychová, Helena Musilová, Ivana Kacerovský, Marian
n3:wos
000342572200020
s:issn
0002-9378
s:numberOfPages
9
n11:doi
10.1016/j.ajog.2014.03.069
n9:organizacniJednotka
11150